scholarly journals Nanoarchitectonics: Complexes and Conjugates of Platinum Drugs with Silicon Containing Nanocarriers. An Overview

2021 ◽  
Vol 22 (17) ◽  
pp. 9264
Author(s):  
Kinga Piorecka ◽  
Jan Kurjata ◽  
Wlodzimierz A. Stanczyk
Keyword(s):  
Drug Delivery ◽  
Driving Force ◽  
State Of The Art ◽  
Platinum Drugs ◽  
Research Groups ◽  
Current State ◽  
Delivery Platform ◽  
Silicon Based ◽  
Intensive Search

The development in the area of novel anticancer prodrugs (conjugates and complexes) has attracted growing attention from many research groups. The dangerous side effects of currently used anticancer drugs, including cisplatin and other platinum based drugs, as well their systemic toxicity is a driving force for intensive search and presents a safer way in delivery platform of active molecules. Silicon based nanocarriers play an important role in achieving the goal of synthesis of the more effective prodrugs. It is worth to underline that silicon based platform including silica and silsesquioxane nanocarriers offers higher stability, biocompatibility of such the materials and pro-longed release of active platinum drugs. Silicon nanomaterials themselves are well-known for improving drug delivery, being themselves non-toxic, and versatile, and tailored surface chemistry. This review summarizes the current state-of-the-art within constructs of silicon-containing nano-carriers conjugated and complexed with platinum based drugs. Contrary to a number of other reviews, it stresses the role of nano-chemistry as a primary tool in the development of novel prodrugs.

Conclusion

2017 ◽  
Author(s):  
Andrea Harris
Keyword(s):  
New York ◽  
Twentieth Century ◽  
New York City ◽  
Driving Force ◽  
George Balanchine ◽  
Current State ◽  
The Arts ◽  
History Of ◽  
Lincoln Center

The Conclusion briefly examines the current state of the New York City Ballet under the auspices of industrial billionaire David H. Koch at Lincoln Center. In so doing, it to introduces a series of questions, warranting still more exploration, about the rapid and profound evolution of the structure, funding, and role of the arts in America through the course of the twentieth century. It revisits the historiographical problem that drives Making Ballet American: the narrative that George Balanchine was the sole creative genius who finally created an “American” ballet. In contrast to that hagiography, the Conclusion reiterates the book’s major contribution: illuminating the historical construction of our received idea of American neoclassical ballet within a specific set of social, political, and cultural circumstances. The Conclusion stresses that the history of American neoclassicism must be seen as a complex narrative involving several authors and discourses and crossing national and disciplinary borders: a history in which Balanchine was not the driving force, but rather the outcome.

scholarly journals Geomorphometry: Today and Tomorrow

2018 ◽  
Author(s):  
John P Wilson
Keyword(s):  
Content Knowledge ◽  
State Of The Art ◽  
High Fidelity ◽  
Terrain Modeling ◽  
Actionable Knowledge ◽  
Digital Terrain ◽  
Current State ◽  
Digital Terrain Modeling ◽  
Key Innovations

This paper summarizes the current state-of-the-art in geomorphometry and describes the innovations that are close at hand and will be required to push digital terrain modeling forward in the future. These innovations will draw on concepts and methods from computer science and the spatial sciences and require greater collaboration to produce “actionable” knowledge and outcomes. The key innovations include rediscovering and using what we already know, developing new digital terrain modeling methods, clarifying and strengthening the role of theory, developing high-fidelity DEMs, developing and embracing new visualization methods, adopting new computational approaches, and making better use of provenance, credibility, and application-content knowledge.

Alpha and Rocker - Two Design Approaches that led to the Successful Challenge for the 2007 International C-Class Catamaran Championship

2009 ◽  
Author(s):  
Steve Killing
Keyword(s):  
Cross Section ◽  
Driving Force ◽  
State Of The Art ◽  
Ride Height ◽  
Current State ◽  
New Thinking ◽  
The Usa

In 2007 Canada entered its first challenge for the International C-Class Catamaran Championship and was victorious in capturing the trophy with five straight wins by Alpha CAN 6 over the venerable Cogito from the USA. Two boats were designed for this challenge - the first was Alpha, a wingsail catamaran, which incorporated some new thinking on sail configuration and hull shape. This made it a successful evolutionary, but not revolutionary, step from the current state-of-the-art boats. Compared to Cogito, the main rival, she had a taller, narrower and thinner wing, lighter construction and more circular hull cross section. The second was Rocker, the bold hydrofoil catamaran, using hulls from the same mold as Alpha and an identical wingsail as the driving force. The daggerboard hydrofoils automatically controlled the ride height with trim tabs, while the control of the rudder elevators was left to the helmsman. Although she flew well, was very controllable, and was spectacular to watch, Rocker could not match the 20 knot plus speed of Alpha.

scholarly journals Polymer Clay Nano-Composites

Polymers ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1445
Author(s):  
Stefano Leporatti
Keyword(s):  
Drug Delivery ◽  
Composite Materials ◽  
Polymer Composite ◽  
State Of The Art ◽  
Environmental Water ◽  
Water Remediation ◽  
Nano Composites ◽  
Special Issue ◽  
Current State ◽  
Exciting Area

Clay–polymer composite materials is an exciting area of research and this Special Issue aims to address the current state-of-the-art of “Polymer Clay Nano-Composites” for several applications, among them antibacterial, environmental, water remediation, dental, drug delivery and others [...]

The growing role of structural mass spectrometry in the discovery and development of therapeutic antibodies

The Analyst ◽  
2018 ◽  
Vol 143 (11) ◽  
pp. 2459-2468 ◽  
Author(s):  
Yuwei Tian ◽  
Brandon T. Ruotolo
Keyword(s):  
Mass Spectrometry ◽  
State Of The Art ◽  
Therapeutic Antibodies ◽  
Critical Importance ◽  
Current State ◽  
Measurement Science ◽  
Structural Mass Spectrometry ◽  
Structural Mass

The comprehensive structural characterization of therapeutic antibodies is of critical importance for the successful discovery and development of such biopharmaceuticals, yet poses many challenges to modern measurement science. Here, we review the current state-of-the-art mass spectrometry technologies focusing on the characterization of antibody-based therapeutics.

scholarly journals Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles

2011 ◽  
Vol 68 (16) ◽  
pp. 2667-2688 ◽  
Author(s):  
Bence György ◽  
Tamás G. Szabó ◽  
Mária Pásztói ◽  
Zsuzsanna Pál ◽  
Petra Misják ◽  
...  
Keyword(s):  
Extracellular Vesicles ◽  
State Of The Art ◽  
Membrane Vesicles ◽  
Current State

scholarly journals Introduction: European Integrated project on Aerosol Cloud Climate and Air Quality interactions (EUCAARI) – integrating aerosol research from nano to global scales

2008 ◽  
Vol 8 (6) ◽  
pp. 19415-19455 ◽  
Author(s):  
M. Kulmala ◽  
A. Asmi ◽  
H. K. Lappalainen ◽  
K. S. Carslaw ◽  
U. Pöschl ◽  
...  
Keyword(s):  
Air Quality ◽  
State Of The Art ◽  
Global Scale ◽  
Research Groups ◽  
Global Models ◽  
Aerosol Cloud ◽  
Operational Systems ◽  
First Results ◽  
Integrated Project

Abstract. The European Aerosol Cloud Climate and Air Quality Interactions project EUCAARI is an EU Research Framework 6 integrated project focusing on understanding the interactions of climate and air pollution. EUCAARI works in an integrative and multidisciplinary way from nano- to global scale. EUCAARI brings together several leading European research groups, state-of-the-art infrastructure and some key scientists from third countries to investigate the role of aerosol on climate and air quality. Altogether 48 partners from 25 countries are participating in EUCAARI. During the first 16 months EUCAARI has built operational systems e.g. established pan-European measurement network for Lagrangian studies and four stations in developing countries. Also an improved understanding of nanoscale processes (like nucleation) has been implemented in global models. Here we present the research methods, organisation, operations and first results of EUCAARI.

Cardiovascular Risk in Psoriasis: Current State of the Art

2018 ◽  
Vol 17 (1) ◽  
pp. 85-91 ◽  
Author(s):  
Giuseppe Dattilo ◽  
Francesco Borgia ◽  
Claudio Guarneri ◽  
Matteo Casale ◽  
Roberto Bitto ◽  
...  
Keyword(s):  
Risk Factor ◽  
Cardiovascular Risk ◽  
Skin Disease ◽  
Independent Risk Factor ◽  
Clinical Laboratory ◽  
State Of The Art ◽  
Mortality And Morbidity ◽  
Current State ◽  
Immune Mediated

Psoriasis (Pso) is a chronic inflammatory immune-mediated skin disease associated with several comorbidities. Despite the growing number of studies providing evidence for the link between Pso and Cardiovascular (CV) disorders, there are still many unsolved questions, dealing with the role of the skin disease as an independent risk factor for CV events, the influence of Pso severity and duration on CV damage, the presence of Psoriatic Arthritis (PsA) as a predictor of increased CV mortality and morbidity and the detection of reliable clinical, laboratory and/or instrumental parameters to stratify CV risk in psoriatic patients. Moreover, it remains to clarify if the early treatment of the dermatosis may lower CV risk. In this paper we will try to provide answers to these queries in the light of the updated data of the literature.

You Need Teachers

PEDIATRICS ◽  
1979 ◽  
Vol 64 (1) ◽  
pp. 125-125
Author(s):  
Miles Weinberger
Keyword(s):  
State Of The Art ◽  
Review Article ◽  
Current State ◽  
Children With Asthma ◽  
Degree Of Control ◽  
Considerable Morbidity ◽  
High Degree ◽  
Changing Role ◽  
Excellent Review Article

The excellent review article by Leffert1 and the accompanying commentary by Bergner2 made important points regarding the changing role of the pediatric allergist and the broad requirements for knowledge of any physicians who are to provide specialty care for children with asthma. While the current state of the art allows a high degree of control for this disease,3 considerable morbidity from inadequately treated asthma persists. This situation is unlikely to change rapidly unless departments of pediatrics place a high priority on ensuring that the modern allergist described by Dr. Bergner is on their faculty to teach the current housestaff and provide continuing education for the practitioner; only then will most general pediatricians be able to assume the role envisioned by Dr. Leffert.

Delving Deeper into Dermal and Transdermal Drug Delivery: Factors and Mechanisms Associated with Nanocarrier-mediated Strategies

2018 ◽  
Vol 24 (27) ◽  
pp. 3210-3222 ◽  
Author(s):  
Jyothsna Manikkath ◽  
TK Sumathy ◽  
Aparna Manikkath ◽  
Srinivas Mutalik
Keyword(s):  
Drug Delivery ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Dispersion Medium ◽  
State Of The Art ◽  
Particle Engineering ◽  
Key Factors ◽  
Current State ◽  
Routes Of Drug Administration ◽  
Drug And Gene Delivery

Background: Advances in material science and particle engineering have led to the development of a rapidly growing number of nanoparticulate carriers for drug and gene delivery. These carriers are increasingly being investigated in dermal and transdermal routes of drug administration. Objective: To critically examine and summarize the primary factors and mechanisms involved in nanocarriermediated dermal and transdermal delivery of drugs. Method: Thorough literature search was undertaken, spanning the early development of nanocarrier-mediated dermal and transdermal drug delivery approaches, to the current state of the art, using online search tools. Results: Physicochemical, formulation, experimental and morphological factors, such as, material of construction or type of nanoparticle (NP), surface chemistry, particle size, particle shape, surface charge, dispersion medium, duration of exposure of skin to NPs, combination of NPs with physical agents, and aspects related to skin were identified and discussed. Conclusion: The key factors and mechanisms which influence NPs-skin interactions in dermal and transdermal drug delivery are discussed in this article in-line with the current advances in the field.

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