Role of Novel Platelet Indices in Patients of Dengue Fever

2019 ◽  
Vol 5 (2) ◽  
pp. 42
Author(s):  
Swati Singh ◽  
Mayurika S Tyagi
Keyword(s):  
Dengue Fever ◽  
Platelet Indices

scholarly journals Role of Platelet Indices as a Potential Marker for Malaria Severity

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Biruk Bayleyegn ◽  
Fikir Asrie ◽  
Aregawi Yalew ◽  
Berhanu Woldu
Keyword(s):  
Severe Malaria ◽  
Malaria Infection ◽  
Warning Signs ◽  
Distribution Width ◽  
Platelet Indices ◽  
Potential Marker ◽  
Immature Platelet Fraction ◽  
Platelet Parameter ◽  
Malaria Severity

Purpose. Platelet parameter alteration such as platelet count and platelet indices are more common than in other blood cell lines due to diverse causative pathophysiological mechanisms in severe malaria infection. In malaria patients, no more studies evaluated platelet indices in relation to disease severity and prognosis. Therefore, this review assessed the current scientific knowledge on the potential role of platelet indices for the diagnostic marker of severe malaria infection. Results. Hence, after reviewing recent literatures, elevation of mean platelet volume and platelet distribution width in addition to decreased plateletcrit and platelet counts is the known potential risk factor associated with warning signs of severe malaria. Thus, thrombocytopenia < 150 × 10 9 / L , MPV ≥ 9.05   fL , and PDW ≥ 14.550 % as well as significantly higher P-LCR and decrease in PCT are shown significant sensitivity and specificity as they are used as diagnostic and prognostic values in severe malaria infection. Conclusion. Platelet indices are useful predictors of malaria severity. Immature platelet fraction (IPF%) is raised in the case of severe malaria, and it was significantly more useful than MPV. Advanced research will further investigate the platelet index abnormality associated with specific age and gender among specific malaria species.

scholarly journals APPLICATION OF ELISA-IGM (MAC-ELISA) FOR DETERMINING ETIOLOGICAL LINK VIRUS TYPES IN CONCRET CASES OF THE DISEASE

2017 ◽  
Vol 22 (3) ◽  
pp. 116-121
Author(s):  
Yuliya A. Akinshina ◽  
V. F Larichev ◽  
M. A Sayfullin ◽  
S. G Mardanly ◽  
A. M Butenko
Keyword(s):  
Dengue Fever ◽  
Rt Pcr ◽  
Serum Samples ◽  
Dengue Viruses ◽  
Etiological Role ◽  
Igm Elisa ◽  
Pcr Method

105 sera from 101 patients with a confirmed diagnosis of dengue fever (LD) were examined using monospecific ELISA-IgM test. Monospecific results were observed in 39 samples (37.1%). 27 sample of them were taken during the first 7 days of the disease. In those systems were examined 23 serum samples of 23 patients, in which etiological role of one of the four dengue viruses was been established by the RT-PCR method. In this case, the coincidence-IgM ELISA results and the RT-PCR took place in 14 sera (60.9%).

scholarly journals Role of platelet distribution width and plateletcrit in assessment of nonthrombocytopenic preeclampsia and eclampsia in a tertiary care hospital of Odisha: an observational study

2020 ◽  
Vol 9 (5) ◽  
pp. 1996
Author(s):  
Kirtirekha Mohapatra ◽  
Pranati Mohanty ◽  
Nahida Nigar Sultana
Keyword(s):  
Platelet Count ◽  
Observational Study ◽  
Severe Disease ◽  
Tertiary Care ◽  
Measurement Tool ◽  
Care Hospital ◽  
Platelet Distribution Width ◽  
Distribution Width ◽  
Platelet Indices

Background: Preeclampsia (PE) is a major cause of maternal and foetal morbidity and mortality in pregnancy. A decreased platelet count is observed during the progression of preeclampsia, and is considered a marker of the severity of preeclampsia. Considering the role of the PDW, PCT and platelet indices during the disease, the aim of this study was to evaluate the feasibility of using platelet indices as a severity marker for PE.Methods: This was a prospective, observational study, hospital-based study, from 2017-19 with 400 pregnant women being included on the basis of a predefined inclusion and exclusion criteria, through antenatal clinic, and labour room of the department of obstetrics and gynecology, S. C. B. Medical College, Cuttack, Odisha, India.Results: Study found that platelet count and plateletcrit showed a significant negative correlation with MAP whereas platelet distribution width showed a maximum positive correlation. In the preeclampsia group, subjects with PCT <0.22% were at risk of developing severe disease with a sensitivity of 53.5% and a high specificity of 85.5%. The AUC of 0.75 showed that it has a good predictability. In the eclampsia group, subjects with PCT <0.16% had a risk of developing severe disease with a sensitivity of 89.5% and specificity of 73.7%. The AUC 0.9 shows PCT to be a good predictor for assessing severity of eclampsia.Conclusions: This study suggests that platelet distribution width and plateletcrit are useful in risk evaluation of preeclampsia. These are a valid measurement tool to predict the severe progression of PE even when normal platelet counts are observed.

Role of T cells, cytokines and antibody in dengue fever and dengue haemorrhagic fever

2006 ◽  
Vol 16 (4) ◽  
pp. 263-275 ◽  
Author(s):  
Joshua Fink ◽  
Feng Gu ◽  
Subhash G. Vasudevan
Keyword(s):  
T Cells ◽  
Dengue Fever ◽  
Dengue Haemorrhagic Fever ◽  
Haemorrhagic Fever

scholarly journals The Role of Vertical Transmission in the Control of Dengue Fever

2019 ◽  
Vol 16 (5) ◽  
pp. 803 ◽  
Author(s):  
David Murillo ◽  
Anarina Murillo ◽  
Sunmi Lee
Keyword(s):  
Dengue Fever ◽  
Vertical Transmission ◽  
Disease Transmission ◽  
Control Function ◽  
Infected Mosquito ◽  
Effective Control ◽  
Control Policies ◽  
Effective Interventions ◽  
Endemic Strain

In this work, a two-strain dengue model with vertical transmission in the mosquito population is considered. Although vertical transmission is often ignored in models of dengue fever, we show that effective control of an outbreak of dengue can depend on whether or not the vertical transmission is a significant mode of disease transmission. We model the effect of a control strategy aimed at reducing human-mosquito transmissions in an optimal control framework. As the likelihood of vertical transmission increases, outbreaks become more difficult and expensive to control. However, even for low levels of vertical transmission, the additional, uncontrolled, transmission from infected mosquito to eggs may undercut the effectiveness of any control function. This is of particular importance in regions where existing control policies may be effective and the endemic strain does not exhibit vertical transmission. If a novel strain that does exhibit vertical transmission invades, then existing, formerly effective, control policies may no longer be sufficient. Therefore, public health officials should pay more attention to the role of vertical transmission for more effective interventions and policy.

scholarly journals Rare neurological presentations of Dengue Fever

2021 ◽  
Vol 18 (1) ◽  
pp. 66-69
Author(s):  
Navgeet Mathur ◽  
Medha Mathur
Keyword(s):  
Dengue Fever ◽  
Treatment Modality ◽  
Nerve Palsy ◽  
Case Series ◽  
Abducens Nerve ◽  
Neurological Manifestations ◽  
Neurological Presentation ◽  
Neurological Features ◽  
Bilateral Abducens

In presence of abnormal neurological features infective, immunological and metabolic etiologies are also needed to be kept as possibility. Dengue fever may present with variety of neurological manifestations. This case series includes rare neurological presentation of dengue fever including first ever reported case of dengue fever induced bilateral abducens nerve palsy with another case of dengue cerebellitis. This case series along with previous studies suggest that imaging may be normal in these cases. This case series also highlighted the possible immunological etio-pathogenesis and role of steroids as treatment modality.

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