scholarly journals A Simple Method for Screening Binary Models with Large Sample Size and Continuous Predictor Variables

2021 ◽  
Vol 7 (4) ◽  
pp. 513-536
Author(s):  
Weichung Joe Shih ◽  
Junfeng Liu
2018 ◽  
pp. 437-445
Author(s):  
Gregory S. Thomas

The chapter Heart Rate Response to Exercise reviews the studies performed to estimate a patient’s maximum predicted heart rate. While the commonly used formula (220 – age), developed in 1971, is easy to remember, it underestimates the actual maximum heart rate in older persons. Studies of large sample size have found the maximum heart rate to be relatively independent of sex and physical fitness but to incrementally decline with age. The decrease with age is less than 1 beat per minute per year, however. A more accurate and recommended formula is [(208) – (0.7)(age)] as developed by Tanaka and colleagues.


1970 ◽  
Vol 7 (01) ◽  
pp. 1-20 ◽  
Author(s):  
Ora Engleberg Percus ◽  
Jerome K. Percus

A generating function technique is used to determine the probability that the deviation between two empirical distributions drawn from the same population lies within a given band a specified number of times. We also treat the asymptotic problem of very large sample size, and obtain explicit expressions when the relative number of failures is very small or very large.


2019 ◽  
Vol 24 (4) ◽  
pp. 408-419
Author(s):  
Hongu Meng ◽  
Antony Warden ◽  
Lulu Zhang ◽  
Ting Zhang ◽  
Yiyang Li ◽  
...  

Mass cytometry (CyTOF) is a critical cell profiling tool in acquiring multiparameter proteome data at the single-cell level. A major challenge in CyTOF analysis is sample-to-sample variance arising from the pipetting process, staining variation, and instrument sensitivity. To reduce such variations, cell barcoding strategies that enable the combination of individual samples prior to antibody staining and data acquisition on CyTOF are often utilized. The most prevalent barcoding strategy is based on a binary scheme that cross-examines the existence or nonexistence of certain mass signals; however, it is limited by low barcoding efficiency and high cost, especially for large sample size. Herein, we present a novel barcoding method for CyTOF application based on mass ratiometry. Different mass tags with specific fixed ratios are used to label CD45 antibody to achieve sample barcoding. The presented method exponentially increases the number of possible barcoded samples with the same amount of mass tags compared with conventional methods. It also reduces the overall time for the labeling process to 40 min and avoids the need for expensive commercial barcoding buffer reagents. Moreover, unlike the conventional barcoding process, this strategy does not pre-permeabilize cells before the barcoding procedure, which offers additional benefits in preserving surface biomarker signals.


2019 ◽  
Vol 7 (9) ◽  
pp. 1801053
Author(s):  
Liu Xie ◽  
Rui Tong ◽  
Wen Zhang ◽  
Dejian Wang ◽  
Tao Liu ◽  
...  

2021 ◽  
pp. 1-12
Author(s):  
Jing Wang ◽  
Jie Wei ◽  
Long Li ◽  
Lijian Zhang

With the rapid development of evidence-based medicine, translational medicine, and pharmacoeconomics in China, as well as the country’s strong commitment to clinical research, the demand for physicians’ research continues to increase. In recent years, real-world studies are attracting more and more attention in the field of health care, as a method of post-marketing re-evaluation of drugs, RWS can better reflect the effects of drugs in real clinical settings. In the past, it was difficult to ensure data quality and efficiency of research implementation because of the large sample size required and the large amount of medical data involved. However, due to the large sample size required and the large amount of medical data involved, it is not only time-consuming and labor-intensive, but also prone to human error, making it difficult to ensure data quality and efficiency of research implementation. This paper analyzes and summarizes the existing application systems of big data analytics platforms, and concludes that big data research analytics platforms using natural language processing, machine learning and other artificial intelligence technologies can help RWS to quickly complete the collection, integration, processing, statistics and analysis of large amounts of medical data, and deeply mine the intrinsic value of the data, real-world research in new drug development, drug discovery, drug discovery, drug discovery, and drug discovery. It has a broad application prospect for multi-level and multi-angle needs such as economics, medical insurance cost control, indications/contraindications evaluation, and clinical guidance.


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