scholarly journals A possible general mechanism of the signal transfer switching on the α/β-interferons expression. 2. The role of the cAMP in the process of the interferon induction

1999 ◽  
Vol 15 (1) ◽  
pp. 83-87
Author(s):  
A. V. Karpov
Keyword(s):  
General Mechanism ◽  
Signal Transfer ◽  
Interferon Induction ◽  
Alpha Beta

scholarly journals The role of brain oscillations in predicting the sensory consequences of your actions

2016 ◽  
Author(s):  
Liyu Cao ◽  
Gregor Thut ◽  
Joachim Gross
Keyword(s):  
Phase Locking ◽  
Beta Phase ◽  
General Mechanism ◽  
Normal Brain ◽  
Alpha Power ◽  
Brain Oscillations ◽  
Neural Information ◽  
Gamma Power ◽  
Alpha Beta

Being able to predict self-generated sensory consequences is an important feature of normal brain functioning. In the auditory domain, self-generated sounds lead to smaller brain responses compared to externally generated sounds. Here we investigated the role of brain oscillations underlying this effect. With magnetoencephalography, we show that self-generated sounds are associated with increased pre-stimulus alpha power and decreased post-stimulus gamma power and alpha/beta phase locking in auditory cortex. All these oscillatory changes are correlated with changes in evoked responses. Furthermore, they correlate with each other across participants, supporting the idea that they constitute a neural information processing sequence for self-generated sounds, with pre-stimulus alpha power representing prediction and post-stimulus gamma power representing prediction error, which is further processed with post-stimulus alpha/beta phase resetting. Additional cross-trial analysis provides further support for the proposed sequence that might reflect a general mechanism for the prediction of self-generated sensory input.

scholarly journals Near-optimal decoding of transient stimuli from coupled neuronal subpopulations

2014 ◽  
Author(s):  
James Trousdale ◽  
Samuel R. Carroll ◽  
Fabrizio Gabbiani ◽  
Krešimir Josić
Keyword(s):  
Visual Processing ◽  
Information Transfer ◽  
Partial Information ◽  
Rotation Axis ◽  
Biophysical Model ◽  
General Mechanism ◽  
Small Subset ◽  
Vertical System ◽  
Optimal Decoding

Coupling between sensory neurons impacts their tuning properties and correlations in their responses. How such coupling affects sensory representations and ultimately behavior remains unclear. We investigated the role of neuronal coupling during visual processing using a realistic biophysical model of the vertical system (VS) cell network in the blow fly. These neurons are thought to encode the horizontal rotation axis during rapid free flight manoeuvres. Experimental findings suggest neurons of the vertical system are strongly electrically coupled, and that several downstream neurons driving motor responses to ego-rotation receive inputs primarily from a small subset of VS cells. These downstream neurons must decode information about the axis of rotation from a partial readout of the VS population response. To investigate the role of coupling, we simulated the VS response to a variety of rotating visual scenes and computed optimal Bayesian estimates from the relevant subset of VS cells. Our analysis shows that coupling leads to near-optimal estimates from a subpopulation readout. In contrast, coupling between VS cells has no impact on the quality of encoding in the response of the full population. We conclude that coupling at one level of the fly visual system allows for near-optimal decoding from partial information at the subsequent, pre-motor level. Thus, electrical coupling may provide a general mechanism to achieve near-optimal information transfer from neuronal subpopulations across organisms and modalities.

scholarly journals Filament formation by metabolic enzymes is a specific adaptation to an advanced state of cellular starvation

2014 ◽  
Author(s):  
Ivana Petrovska ◽  
Elisabeth Nüske ◽  
Matthias C Munder ◽  
Gayathrie Kulasegaran ◽  
Liliana Malinovska ◽  
...  
Keyword(s):  
Metabolic Enzymes ◽  
Low Ph ◽  
General Mechanism ◽  
Filament Formation ◽  
Ph Change ◽  
Cooperative Process ◽  
A Cell ◽  
Enzymatic Inactivation ◽  
Physical Organization

One of the key questions in biology is how the metabolism of a cell responds to changes in the environment. In budding yeast, starvation causes a drop in intracellular pH, but the functional role of this pH change is not well understood. Here, we show that the enzyme glutamine synthetase (Gln1) forms filaments at low pH and that filament formation leads to enzymatic inactivation. Filament formation by Gln1 is a highly cooperative process, strongly dependent on macromolecular crowding, and involves back-to-back stacking of cylindrical homo-decamers into filaments that associate laterally to form higher order fibrils. Other metabolic enzymes also assemble into filaments at low pH. Hence, we propose that filament formation is a general mechanism to inactivate and store key metabolic enzymes during a state of advanced cellular starvation. These findings have broad implications for understanding the interplay between nutritional stress, the metabolism and the physical organization of a cell.

scholarly journals Restoration of subjectivity: the role of reflection in personality development and humanization of social institutions

2021 ◽  
pp. 1-16
Author(s):  
Vadim Markovich Rozin ◽  
Lyudmila Mikhailovna Karnozova
Keyword(s):  
Restorative Justice ◽  
Personality Development ◽  
Social Institutions ◽  
General Mechanism ◽  
Second Phase ◽  
Resolution Analysis ◽  
Two Phases ◽  
New Perspective ◽  
Personality Process

This article consists of two parts. The firs parts analyzes the general mechanism of reflection within the framework of the theoretical discourse; while the second part the introduced concepts and schemes of reflection are illustrated on the case of “restorative justice”. The analysis of two other cases (“Confession” by St. Augustine, as well as “Confessions” and “Resurrection” by L. Tolstoy) allows characterizing the two phases of psyche – preceding and accompanying reflection. The first phase represents a “crystallization of distortion subjectivity”, and at times its dissolution. The second phase (situation) launches the personality process, which can be described using the terminology of L. S. Vygotstky as “interiorization" of intersubjective; this is the conscious work that gives a new perspective on the situation and its resolution. Analysis is conducted on the two procedures of reflection itself ‒ reflexive way out to the space of “placelesness” (M. Bakhtin) with the shift of integrity and thingness, and reflexive return (G. Shchedrovitsky). Study of the case of restorative justice demonstrates the organizational-technical attitude towards reflection, communication and ensuring mutual understanding between people separated by crime, as a new moment in comparison with the “individual reflection” as internally determined personality process. The inclusion of reflection into social practices and humanities substantiates the possibility of complementing the concept of subjectivity and its “restoration” with the concept of agency as the proclivity for new actions, acquisition of the “authorial position” in relation to one's personal life and interaction with others.

scholarly journals ISG15 Arg151 and the ISG15-Conjugating Enzyme UbE1L Are Important for Innate Immune Control of Sindbis Virus

2008 ◽  
Vol 83 (4) ◽  
pp. 1602-1610 ◽  
Author(s):  
Nadia V. Giannakopoulos ◽  
Elena Arutyunova ◽  
Caroline Lai ◽  
Deborah J. Lenschow ◽  
Arthur L. Haas ◽  
...  
Keyword(s):  
Virus Infection ◽  
Survival Benefit ◽  
Sindbis Virus ◽  
Innate Immune ◽  
Protein Conjugates ◽  
Antiviral Effects ◽  
Antiviral Function ◽  
Alpha Beta

ABSTRACT Interferon (IFN)-stimulated gene 15 (ISG15) is a ubiquitin-like molecule that conjugates to target proteins via a C-terminal LRLRGG motif and has antiviral function in vivo. We used structural modeling to predict human ISG15 (hISG15) residues important for interacting with its E1 enzyme, UbE1L. Kinetic analysis revealed that mutation of arginine 153 to alanine (R153A) ablated hISG15-hUbE1L binding and transthiolation of UbcH8. Mutation of other predicted UbE1L-interacting residues had minimal effects on the transfer of ISG15 from UbE1L to UbcH8. The capacity of hISG15 R153A to form protein conjugates in 293T cells was markedly diminished. Mutation of the homologous residue in mouse ISG15 (mISG15), arginine 151, to alanine (R151A) also attenuated protein ISGylation following transfection into 293T cells. We assessed the role of ISG15-UbE1L interactions in control of virus infection by constructing double subgenomic Sindbis viruses that expressed the mISG15 R151A mutant. While expression of mISG15 protected alpha/beta-IFN-receptor-deficient (IFN-αβR−/−) mice from lethality following Sindbis virus infection, expression of mISG15 R151A conferred no survival benefit. The R151A mutation also attenuated ISG15's ability to decrease Sindbis virus replication in IFN-αβR−/− mice or prolong survival of ISG15−/− mice. The importance of UbE1L was confirmed by demonstrating that mice lacking this ISG15 E1 enzyme were highly susceptible to Sindbis virus infection. Together, these data support a role for protein conjugation in the antiviral effects of ISG15.

scholarly journals JAK/STAT Activation: A General Mechanism for Bone Development, Homeostasis, and Regeneration

2020 ◽  
Vol 21 (23) ◽  
pp. 9004
Author(s):  
Alexandra Damerau ◽  
Timo Gaber ◽  
Sarah Ohrndorf ◽  
Paula Hoff
Keyword(s):  
Signaling Pathway ◽  
Bone Development ◽  
Gene Knockout ◽  
Selective Inhibition ◽  
Janus Kinase ◽  
General Mechanism ◽  
Stat Signaling ◽  
Skeletal Phenotype ◽  
Pro Inflammatory Cytokines

The Janus kinase (JAK) signal transducer and activator of transcription (STAT) signaling pathway serves as an important downstream mediator for a variety of cytokines, hormones, and growth factors. Emerging evidence suggests JAK/STAT signaling pathway plays an important role in bone development, metabolism, and healing. In this light, pro-inflammatory cytokines are now clearly implicated in these processes as they can perturb normal bone remodeling through their action on osteoclasts and osteoblasts at both intra- and extra-articular skeletal sites. Here, we summarize the role of JAK/STAT pathway on development, homeostasis, and regeneration based on skeletal phenotype of individual JAK and STAT gene knockout models and selective inhibition of components of the JAK/STAT signaling including influences of JAK inhibition in osteoclasts, osteoblasts, and osteocytes.

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