A Follow-up Study of Liver Function Tests in AMHTS

Abnormal liver function tests (LFTs) are known to be associated with impaired clinical outcomes in heart failure (HF) patients. However, this implication varies with each single LFT panel. We aim to evaluate the long-term outcomes of acute HF (AHF) patients by assessing multiple LFT panels in combination. From a prospective multicenter registry in Japan, 1158 AHF patients who were successfully discharged were analyzed (mean age, 73.9 ± 13.5 years; men, 58%). LFTs (i.e., total bilirubin, aspartate aminotransferase or alanine aminotransferase, and alkaline phosphatase) at discharge were assessed; borderline and abnormal LFTs were defined as 1 and ≥2 parameter values above the normal range, respectively. The primary endpoint was composite of all-cause death or HF readmission. At the time of discharge, 28.7% and 8.6% of patients showed borderline and abnormal LFTs, respectively. There were 196 (16.9%) deaths and 298 (25.7%) HF readmissions during a median 12.4-month follow-up period. The abnormal LFTs group had a significantly higher risk of experiencing the composite outcome (adjusted hazard ratio: 1.51, 95% confidence interval: 1.08–2.12, p = 0.017), whereas the borderline LFTs group was not associated with higher risk of adverse events when referenced to the normal LFTs group. Among AHF patients, the combined elevation of ≥2 LFT panels at discharge was associated with long-term adverse outcomes.

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Adherence to Clinical Follow-Up Recommendations for Liver Function Tests: A Cross-sectional Study of Patients with HCV and their Associated Risk Behaviors

Preventive Medicine Reports ◽

10.1016/j.pmedr.2021.101482 ◽

2021 ◽

pp. 101482

Author(s):

Allison Dormanesh ◽

Judy Huei-yu Wang ◽

Ranit Mishori ◽

Paula Cupertino ◽

Joshua Longcoy ◽

...

Keyword(s):

Liver Function ◽

Risk Behaviors ◽

Liver Function Tests ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Function Tests

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Cystic fibrosis-related liver disease: a single-center experience

Pediatric Reports ◽

10.4081/pr.2011.e21 ◽

2011 ◽

Vol 3 (3) ◽

pp. 21 ◽

Cited By ~ 4

Author(s):

Paula Catarino Costa ◽

Celeste Canha Barreto ◽

Luisa Pereira ◽

Maria Luisa Lobo ◽

Maria Adília Costa ◽

...

Keyword(s):

Cystic Fibrosis ◽

Liver Disease ◽

Liver Function ◽

Pediatric Patients ◽

Liver Function Tests ◽

Liver Involvement ◽

Clinical Expression ◽

Function Tests ◽

Related Liver Disease

Prospective studies concerning liver disease in pediatric cystic fibrosis patients are scarce. The present study aimed to describe the prevalence and clinical expression of cystic fibrosis - related liver disease, in a cohort of 62 pediatric patients. Descriptive study, resulting from the prospective evaluation, between 1994 and 2009, of 62 pediatric patients (age <18 years) with cystic fibrosis. The follow-up protocol included a clinical assessment every 2 months, liver function tests every 6 months and annual liver ultrasonography. The cumulative prevalence of liver disease was 11.2% (7/62 cases). All patients had ΔF508 mutation and pancreatic insufficiency, none had meconium ileus. The liver involvement became clinically evident at a mean age of 8 years (3-15 years), revealed by hepatomegaly or hepatosplenomegaly (3 cases) and/ or abnormalities of liver function tests (3 cases) changes of liver ultrasound (7 cases) with evidence of portal hypertension (2 cases). Four patients were submitted to liver biopsy; biliary fibrosis was documented in one case, focal biliary cirrhosis in 2 cases and multilobular cirrhosis in another case. Within a median 11.6 years follow-up period (all patients under UDCA therapy after liver disease diagnosis), progression of liver disease was observed in 2 patients; one patient developed refractory variceal bleeding and progressive hepatic failure, requiring liver transplant. The results of the present study agree with those of previous pediatric studies, further documenting clinical expression of liver disease in CF patients, which is usually detected in the first decade of life and emphasize the contribution of ultrasound to early diagnosis of liver involvement. Moreover, although advanced liver disease is a relatively rare event, early isolated liver transplantation may have to be considered at this age group.

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Diagnosis experiences from 50 hepatitis B patients in Chongqing, China: a qualitative study

BMC Public Health ◽

10.1186/s12889-021-11929-9 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Xiangxi Zhou ◽

Fan Zhang ◽

Yongping Ao ◽

Chunli Lu ◽

Tingting Li ◽

...

Keyword(s):

Hepatitis B ◽

Liver Function ◽

Healthy Lifestyle ◽

Signs And Symptoms ◽

Liver Function Tests ◽

Irreversible Damage ◽

Function Tests ◽

Professional Mental Health ◽

The Impact

Abstract Background The aim of this study was to provide recommendations for reducing the impact of hepatitis B infection on patients with chronic hepatitis B by describing their experiences during the diagnosis process. Methods We conducted face-to-face interviews with 50 hepatitis B patients recruited by convenient sampling from an infectious diseases department of a teaching hospital in Chongqing, China from July to August 2019. Thematic analysis framework included interviewees’ social demographic characteristics, diagnosis approach, signs and symptoms before diagnosis, feelings after diagnosis, and doctor’s instructions. Results Most patients first detected hepatitis B through various types of physical examinations when the patients were asymptomatic or had only mild symptoms. Most patients were shocked, scared, or overwhelmed when they were diagnosed with hepatitis B. They were able to remember the doctor’s instructions about maintaining a healthy lifestyle, but not impressed by the doctor’s advice about regular follow-up liver function tests. The lack of regular follow-up has caused irreversible damage to some patients. Conclusions Most patients are passively diagnosed with hepatitis B due to their lack of awareness on active hepatitis B prevention. Patients need professional mental health care to overcome the negative emotions that following the diagnosis. Physicians’ instruction should emphasize the importance of regular follow-up liver function tests in addition to a healthy lifestyle.

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Significance of Abnormal Liver Function Tests in Hemophiliacs: A Follow-Up Study

10.1055/s-0039-1682583 ◽

1977 ◽

Author(s):

P.M. Mannucci ◽

Z.M. Ruggeri ◽

A. Capitanio ◽

F. Pareti

Keyword(s):

Liver Function ◽

Clinical Evidence ◽

Liver Function Tests ◽

Abnormal Liver Function ◽

Function Tests ◽

Number Of Patients ◽

High Incidence ◽

Therapeutic Measures ◽

Observation Period

It was previously shown (1) that hemophiliacs have a high incidence of abnormal liver function tests unaccompanied by clinical evidence of illness. Since single measurements are of little use to access the significance of such abnormalities and their possible relationship with chronic hepatitis, hemophiliacs with abnormal liver function tests were regularly followed with measurements carried out at least once a year. 20 patients with raised SGOT-SGPT were followed for up to 3 years; in 9, the abnormalities persisted throughout the whole observation period, whereas in 2 the enzymes were occasionally increased and in 9 they were always normal since the initial abnormal measurement. Out of 39 patients with increased serum gamma-globulins, abnormal values were 1 persistently observed in 11 followed for 3 years. In 28 patients followed for 2 years, persistently abnormal values were found in 21, whereas in 7 normal values were invariably found since the initial abnormal measurement. These findings show that liver function tests are persistently abnormal in a number of patients; in these, biopsy should be considered in order to undertake suitable therapeutic measures.

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Conventional and quantitative liver function tests after hepatic transplantation: a prospective long term follow-up

Transplant International ◽

10.1007/s001470050044 ◽

1997 ◽

Vol 10 (3) ◽

pp. 212-216 ◽

Cited By ~ 2

Author(s):

Jürgen von Schönfeld ◽

Jochen Erhard ◽

Mechtild Beste ◽

Marc Mahl ◽

Rainer B. Zotz ◽

...

Keyword(s):

Liver Function ◽

Liver Function Tests ◽

Hepatic Transplantation ◽

Function Tests ◽

Long Term Follow Up

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Deranged liver function tests in pregnancy: the importance of postnatal follow-up

Obstetric Medicine ◽

10.1258/om.2008.080036 ◽

2009 ◽

Vol 2 (1) ◽

pp. 32-33 ◽

Cited By ~ 4

Author(s):

Sophia Stone ◽

Joanna C Girling

Keyword(s):

Liver Function ◽

Hepatic Duct ◽

First Trimester ◽

Liver Function Tests ◽

Common Hepatic Duct ◽

Imaging Studies ◽

Function Tests ◽

New Finding ◽

The Common

We report an asymptomatic 40-year-old woman with persistently deranged liver function tests found incidentally in the first trimester of her second pregnancy. No cause was apparent clinically, serologically or with imaging studies until a new finding of hepatomegaly led to a repeat ultrasound scan six weeks following delivery. A mass in the region of the common hepatic duct was confirmed to be a cholangiocarcinoma, with vascular invasion precluding curative surgical resection. This case highlights the need for close vigilance of patients with unexplained and persistently abnormal liver function tests, antenatally and postdelivery.

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