scholarly journals Poly(lactic-co-glycolic acid) based double emulsion nanoparticle as a carrier system to deliver glutathione sublingually

2018 ◽  
Vol 3 ◽  
pp. 50-59 ◽  
Author(s):  
Guanyu Chen ◽  
Jingyuan Wen
Keyword(s):  
Glycolic Acid ◽  
Double Emulsion ◽  
Carrier System

The Current Research Status of PLGA as Drug and Gene Carrier

2016 ◽  
Vol 42 ◽  
pp. 80-91 ◽  
Author(s):  
Ji Wei Wu ◽  
Guo Hua Li ◽  
Shu Qin Cui ◽  
Jing He Wang ◽  
Xiang Ling Gu ◽  
...  
Keyword(s):  
Immune Response ◽  
Surface Modification ◽  
Controlled Release ◽  
Glycolic Acid ◽  
Drug Carrier ◽  
Synthetic Methods ◽  
Carrier System ◽  
Carrier Materials ◽  
Controlled Release System ◽  
Drug Carrier System

PLGA, poly (lactic-co-glycolic-acid), is a kind of biodegradable functional macromolecular organic compounds. PLGA, certified by the Food and Drug Administration (FDA), possesses desirable features of biocompatibility, nontoxicity and no immune response, and is being widely applied to human clinical medical research. Because of its biodegradability, simple synthetic methods, controllability of degrading rate and desirable plasticity, PLGA was applied in large quantity into the carrier materials which is to control the release in recent years, gradually propelling PLGA microsphere controlled release system to be the most ideal drug-carrier system at present. As the carrier of drug and genes, PLGA is mainly researched on its features as the carrier, synthetic methods, different surface modification methods, and the applications on different drugs, genetic treatments and genetic vaccines.

scholarly journals FORMULATION AND EVALUATION OF ISORHAMNETIN LOADED POLY LACTIC-CO-GLYCOLIC ACID NANOPARTICLES

2017 ◽  
Vol 10 (11) ◽  
pp. 177
Author(s):  
Kandakumar Settu ◽  
Manju Vaiyapuri
Keyword(s):  
Particle Size ◽  
Glycolic Acid ◽  
Polymeric Nanoparticles ◽  
Double Emulsion ◽  
Spherical Shape ◽  
Particle Size Analysis ◽  
Size Analysis ◽  
Characteristic Variety ◽  
Sem Image ◽  
Flexible Technology

  Objective: The aim of the present study was formulation and evaluation of isorhamnetin loaded poly lactic-co-glycolic acid (PLGA) polymeric nanoparticles (NPs).Methods: The present study was designed to incorporate the isorhamnetin in PLGA formulation by double emulsion solvent evaporation method, which offers a dynamic and flexible technology for enhancing drug solubility due to their biphasic characteristic, variety in design, composition and assembly. Synthesized isorhamnetin-PLGA NPs were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and particle size analyzer. We tested the efficacy of isorhamnetin-PLGA NPs in HepG2 cell lines.Results: From the FTIR result, we concluded that -C-N-, -C=C-, N-H, C-N, N-O, O-H, and C-H are the functional groups present in isorhamnetin-PLGA NPs, SEM image shows spherical shape of particles. The particle size analysis result shows 255-342 nm range of particles. Isorhamnetin-PLGA NPs significantly enhanced (p<0.05) the antiproliferative effect when compared to the plain drug.Conclusion: This study concluded that the newly formulated NP drug delivery systems of isorhamnetin provided an insight into the therapeutic effectiveness of the designed formulation for the treatment of chemotherapy.

Effect of Additives on Characteristics of Poly(3-Hydroxybutyrate) Microspheres

2010 ◽  
Vol 160-162 ◽  
pp. 54-59 ◽  
Author(s):  
Fan Li ◽  
Feng Tian ◽  
Chang Jun Liu
Keyword(s):  
Polyethylene Glycol ◽  
Glycolic Acid ◽  
Drug Loading ◽  
Double Emulsion ◽  
Average Diameter ◽  
Morphological Characters ◽  
Good Effect ◽  
Protein Loading ◽  
Effect Of Additives ◽  
Surface Morphologies

Poly(3-hydroxybutyrate) (PHB) based microspheres were prepared via double emulsion solvent evaporation using polyethylene glycol (PEG), poly-3-hydroxybutyrate-co-3-hydroxyvalerate (PHBV), polylactide (PLA), poly(dl-lactic-co-glycolic acid) (PLGA) or chitosan (CTS) as the additive of wall polymers. It was found that additives had distinct effect on the properties of microspheres, such as the yield, drug loading, average diameter, crystallization states microstructure and surface morphological characters. PHB based microspheres using PEG as the additive had the lowest yield, the smallest average diameter, and the highest drug loading which reached 12.2% thereinto. At the same time it had the lowest crystallinity of PHB, and the diameter of the crystal particles was only 11.44 nm. It was feasible to prepare PHB based microspheres using PEG and PHBV as additives, which had relatively high protein loading but different microstructures and surface morphologies, and they were anticipated to have a good effect of controlled release.

scholarly journals Encapsulation of Nicardipine Hydrochloride and Release from Biodegradable Poly(D,L-lactic-co-glycolic acid) Microparticles by Double Emulsion Process: Effect of Emulsion Stability and Different Parameters on Drug Entrapment

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Nopparuj Soomherun ◽  
Narumol Kreua-ongarjnukool ◽  
Sorayouth Chumnanvej ◽  
Saowapa Thumsing
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Glycolic Acid ◽  
Release Kinetics ◽  
Double Emulsion ◽  
Average Diameter ◽  
Optimal Processing ◽  
Alternative Drug ◽  
Biodegradable Poly

Poly(D,L-lactic-co-glycolic acid) (PLGA) is an important material used in drug delivery when controlled release is required. The purpose of this research is to design and characterize PLGA microparticles (PLGA MPs) implants for the controlled release of nicardipine hydrochloride (NCH) in vitro. This study used the water-in-oil-in-water (w1/o/w2) double emulsion and solvent diffusion/evaporation approach to prepare PLGA MPs. Optimal processing conditions were found, such as polymer content, surfactant type, stabilizer concentration, inner and outer aqueous phase volumes, and stirring speed. The PLGA MPs for use as nicardipine hydrochloride (NCH) loading and release had spherical morphology, and the average diameter was smaller than 5.20±0.25 μm. The release kinetics were modeled to elucidate the possible mechanism of drug release. In vitro release studies indicated that the NCH release rate is slow and continuous. PLGA MPs are an interesting alternative drug delivery system, especially for use with NCH for biomedical applications.

scholarly journals Development of Poly Lactic/Glycolic Acid (PLGA) Microspheres for Controlled Release of Rho-Associated Kinase Inhibitor

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Sho Koda ◽  
Naoki Okumura ◽  
Junji Kitano ◽  
Noriko Koizumi ◽  
Yasuhiko Tabata
Keyword(s):  
High Performance ◽  
Glycolic Acid ◽  
Kinase Inhibitor ◽  
Rho Kinase ◽  
Double Emulsion ◽  
Plga Microspheres ◽  
Rock Inhibitor ◽  
Drug Delivery Carrier ◽  
Composition Ratios

Purpose. The purpose of this study was to investigate the feasibility of poly lactic/glycolic acid (PLGA) as a drug delivery carrier of Rho kinase (ROCK) inhibitor for the treatment of corneal endothelial disease. Method. ROCK inhibitor Y-27632 and PLGA were dissolved in water with or without gelatin (W1), and a double emulsion [(W1/O)/W2] was formed with dichloromethane (O) and polyvinyl alcohol (W2). Drug release curve was obtained by evaluating the released Y-27632 by using high performance liquid chromatography. PLGA was injected into the anterior chamber or subconjunctiva in rabbit eyes, and ocular complication was evaluated by slitlamp microscope and histological analysis. Results. Y-27632 incorporated PLGA microspheres with different molecular weights, and different composition ratios of lactic acid and glycolic acid were fabricated. A high molecular weight and low content of glycolic acid produced a slower and longer release. The Y-27632 released from PLGA microspheres significantly promoted the cell proliferation of cultured corneal endothelial cells. The injection of PLGA did not induce any evident eye complication. Conclusions. ROCK inhibitor-incorporated PLGA microspheres were fabricated, and the microspheres achieved the sustained release of ROCK inhibitor over 7–10 days in vitro. Our data should encourage researchers to use PLGA microspheres for treating corneal endothelial diseases.

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