scholarly journals Validation of the 2-Minute Walk Test with the 6-Minute Walk Test and Other Functional Measures in Persons with Multiple Sclerosis

2018 ◽  
Vol 20 (4) ◽  
pp. 158-163 ◽  
Author(s):  
David A. Scalzitti ◽  
Kenneth J. Harwood ◽  
Joyce R. Maring ◽  
Susan J. Leach ◽  
Elizabeth A. Ruckert ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gait Speed ◽  
Discriminant Validity ◽  
Alternative Measure ◽  
Walk Test ◽  
Timed Up And Go ◽  
Cross Sectional ◽  
Functional Measures ◽  
6 Minute Walk Test ◽  
Minute Walk

Abstract Background: Persons with multiple sclerosis (MS) commonly have difficulty walking. The 6-Minute Walk Test (6MWT) assesses functional capacity but may be considered burdensome for persons with MS, especially those with higher disability levels. The 2-Minute Walk Test (2MWT) may be an alternative measure to the 6MWT. The purpose of this study was to investigate the validity of the 2MWT in persons with MS. Methods: Twenty-eight ambulatory persons with MS aged 18 to 64 years participated in this cross-sectional study. Participants completed five measures of walking performance (2MWT, 6MWT, usual and fast gait speed, and Timed Up and Go test) and two functional measures (Berg Balance Scale and five-times sit-to-stand test) during a testing session. Participants were classified into two subgroups based on Disease Steps scale classification. Results: The 2MWT was significantly correlated with the 6MWT (r = 0.947), usual gait speed (r = 0.920), fast gait speed (r = 0.942), the Timed Up and Go test (r = −0.911), and other functional measures. The 2MWT explained 89% of the variance seen during the 6MWT. The distances completed on the 2MWT and 6MWT accurately distinguished the subgroups. Conclusions: This study demonstrated good construct and discriminant validity of the 2MWT in persons with MS, providing an efficient and practical alternative to the 6MWT. Validation of the 2MWT with other functional measures further supports these findings.

scholarly journals Validity and Reliability of Four Clinical Gait Measures in Patients with Multiple Sclerosis

2017 ◽  
Vol 19 (5) ◽  
pp. 247-252 ◽  
Author(s):  
Susan E. Bennett ◽  
Lacey E. Bromley ◽  
Nadine M. Fisher ◽  
Machiko R. Tomita ◽  
Paulette Niewczyk
Keyword(s):  
Multiple Sclerosis ◽  
Reliability And Validity ◽  
Time Of Day ◽  
Self Report ◽  
Walk Test ◽  
Validity And Reliability ◽  
Timed Up And Go ◽  
Edss Score ◽  
6 Minute Walk Test ◽  
Minute Walk

Background: The gold standards for assessing ambulation are the Expanded Disability Status Scale (EDSS) and the Timed 25-Foot Walk (T25FW) test. In relation with these measures, we assessed the reliability and validity of four clinical gait measures: the Timed Up and Go (TUG) test, the Dynamic Gait Index (DGI), the 2-Minute Walk Test (2MWT), and the 6-Minute Walk Test (6MWT). Patient self-report of gait was also assessed using the 12-item Multiple Sclerosis Walking Scale (MSWS-12). Methods: Individuals 20 years or older with a diagnosis of multiple sclerosis (MS) and an EDSS score of 2.0 to 6.5 completed the MSWS-12, T25FW test, TUG test, DGI, 2MWT, and 6MWT. All the tests were repeated 2 weeks later at the same time of day to establish their reliability and concurrent validity. Predictive validity was established using the EDSS. Results: Forty-two patients with MS were included. All measures showed high test-retest reliability. The TUG test, 2MWT, and 6MWT were significantly correlated with the T25FW test (Spearman ρ = −0.902, −0.919, and −0.905, respectively). The EDSS was also significantly correlated with all the walking tests. The MSWS-12 demonstrated the highest correlation to the EDSS (ρ = 0.788). Conclusions: The TUG test, the DGI, the 2MWT, and the 6MWT exhibited strong psychometric properties and were found to be significant predictors of the EDSS score. Use of these tests to prospectively monitor the effects of medical and rehabilitation treatment should be considered in the comprehensive care of patients with MS.

scholarly journals Objectively Measured Physical Activity in Asymptomatic Middle-Aged Men Is Associated With Routine Blood-Based Biomarkers

2019 ◽  
Vol 74 (Supplement_1) ◽  
pp. S32-S37 ◽  
Author(s):  
Karol M Pencina ◽  
Zhuoying Li ◽  
Monty Montano
Keyword(s):  
Physical Activity ◽  
T Cell ◽  
Gait Speed ◽  
Sex Hormone Binding Globulin ◽  
Walk Test ◽  
Middle Aged ◽  
Cross Sectional ◽  
Increased Risk ◽  
6 Minute Walk Test ◽  
Minute Walk

Abstract Background The use of circulating clinically routine biomarkers and volitional physical activity using wristband accelerometry in preclinical middle-aged adults may provide sensitive measures of physical function and predict sooner the onset of age- and HIV-related physical decline. Methods Nested cross-sectional cohort study of adult men 50–65 years old with HIV infection on potent antiretroviral therapy and uninfected control participants within the Boston metropolitan area. Gait speed derived from wristband accelerometry, gait speed derived from a standardized 6-minute walk test, cellular immune biomarker levels (CD4 T cell, CD8 T cell), and serum anabolic biomarker levels (total and free testosterone, and sex-hormone-binding globulin) were measured. Results Of the five measured biomarkers, four were significantly associated with volitional gait speed based on accelerometry, whereas only one was associated with gait speed based on the 6-minute walk test collected in a laboratory environment. Conclusion Levels of selected immune and anabolic biomarkers were associated with volitional physical activity in middle-aged individuals. Digital and circulating biomarkers may be useful in future studies designed to identify presymptomatic individuals at increased risk for age- and HIV-associated functional decline.

Fatigue-induced alterations of gait in Multiple Sclerosis through an instrumented 6-Minute Walk Test: A pilot study

2018 ◽  
Vol 66 ◽  
pp. S8-S9
Author(s):  
I. Carpinella ◽  
E. Gervasoni ◽  
D. Anastasi ◽  
M. Ferrarin ◽  
D. Cattaneo
Keyword(s):  
Multiple Sclerosis ◽  
Pilot Study ◽  
Walk Test ◽  
6 Minute Walk Test ◽  
Minute Walk

Energy Cost During the 6-Minute Walk Test and Its Relationship to Real-World Walking After Stroke: A Correlational, Cross-Sectional Pilot Study

2019 ◽  
Vol 99 (12) ◽  
pp. 1656-1666
Author(s):  
Jean A M Ribeiro ◽  
Simone G Oliveira ◽  
Luciana Di Thommazo-Luporini ◽  
Clara I Monteiro ◽  
Shane A Phillips ◽  
...  
Keyword(s):  
Pilot Study ◽  
Energy Cost ◽  
Activity Monitor ◽  
Walk Test ◽  
Ambulatory Activity ◽  
Cross Sectional ◽  
6 Minute Walk Test ◽  
Minute Walk ◽  
High Cadence ◽  
Energy Cost Of Walking

Abstract Background After experiencing stroke, individuals expend more energy walking than people who are healthy. However, among individuals who have experienced stroke, the correlation between the energy cost of walking, as measured by validated tests (such as the 6-minute walk test), and participation in walking, as measured by more sensitive tools (such as an ambulatory activity monitor), remains unknown. Objective The main objective of this study was to determine whether the energy cost of walking is correlated with participation in walking. Design This study was a correlational, cross-sectional pilot study. Methods Data from 23 participants who had experienced chronic stroke were analyzed. On the first day, data on oxygen uptake were collected using a portable metabolic system while participants walked during the 6-minute walk test. Then, the ambulatory activity monitor was placed on the participants’ nonparetic ankle and removed 9 days later. The energy cost of walking was calculated by dividing the mean oxygen uptake recorded during the steady state by the walking speed. Results The energy cost of walking was correlated with the following: the number of steps (Spearman rank correlation coefficient [rs] = −0.59); the percentage of time spent in inactivity (rs = 0.48), low cadence (rs = 0.67), medium cadence (rs = −0.56), high cadence (rs = −0.65), and the percentages of steps taken at low cadence (rs = 0.65) and high cadence (rs = −0.64). Limitations Individuals who were physically inactive, convenience sampling, and a small sample size were used in this study. Conclusions Higher energy costs of walking were associated with fewer steps per day and lower cadence in real-world walking in individuals who had experienced stroke.

scholarly journals Predictive validity analysis of six reference equations for the 6-minute walk test in healthy Brazilian men: a cross-sectional study

2017 ◽  
Vol 21 (5) ◽  
pp. 350-356 ◽  
Author(s):  
Alexandher Negreiros ◽  
Rosimeire Simprini Padula ◽  
Rosane Andrea Bretas Bernardes ◽  
Mônica Vasconcelos de Moraes ◽  
Raquel Simoni Pires ◽  
...  
Keyword(s):  
Predictive Validity ◽  
Cross Sectional Study ◽  
Walk Test ◽  
Sectional Study ◽  
Cross Sectional ◽  
Validity Analysis ◽  
Reference Equations ◽  
6 Minute Walk Test ◽  
Minute Walk

Increased Falls Risk Following A 6-Minute Walk Test In Persons with Multiple Sclerosis

2015 ◽  
Vol 47 ◽  
pp. 359
Author(s):  
Corey A. Rynders ◽  
Christopher Vaughan ◽  
Candace Nordin ◽  
Jake Sosnoff ◽  
Steven Morrison
Keyword(s):  
Multiple Sclerosis ◽  
Walk Test ◽  
Falls Risk ◽  
6 Minute Walk Test ◽  
Minute Walk

scholarly journals 'CORRELATION OF 6 MINUTE WALK TEST WITH CLINICO-RADIOLOGICAL PARAMETERS IN STABLE COPD PATIENTS

2020 ◽  
pp. 1-2
Author(s):  
Manish Meena ◽  
Aashish Kumar Singh* ◽  
Shashi Prakash Agnihotri
Keyword(s):  
Cross Sectional Study ◽  
Clinical Severity ◽  
Walk Test ◽  
Cross Sectional ◽  
Medical College ◽  
Six Minute Walk Test ◽  
Copd Patients ◽  
Severity Of The Disease ◽  
6 Minute Walk Test ◽  
Minute Walk

Background: Six minute walk test (6MWT), represent a useful marker for exercise capacity and dynamic hyperination of COPD patients.Highresolution computed tomography (HRCT) has allowed in detection of airway wall abnormalities and emphysema, whose extent may correlate with the clinical severity of the disease in COPD patients. Material & methods: A cross sectional study was carried in 100 COPD patients attending Department of Respiratory Medicine, Institute of respiratory diseases, SMS Medical College, Jaipur, during June 2018 to May 2019.All patients underwent clinically (Modied Medical Research Council), radiologically (HRCT) &6MWT. Results:The 6MWTshowed that a negative correlation to dyspnea (mMRC grading), emphysema score & post FEV1% predicted (p<0.0001). Conclusion:The HRCTemphysema score can be used as an initial parameter for identify patients with high risk for COPD.

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