scholarly journals Levels metaphor and building blocks—towards a domain granularity framework for the life sciences

2016 ◽  
Author(s):  
Lars Vogt
Keyword(s):  
Life Sciences ◽  
Formal Theory ◽  
Building Blocks ◽  
The Other ◽  
General Domain ◽  
Comprehensive Information ◽  
Initial Basis ◽  
Information Framework

Arranging a heterogeneous collection of entities into a hierarchy of linearly ordered levels (layers or strata) is a general ordering scheme that is a widely used notion for organizing knowledge. On the basis of four specific examples, all of which are relevant in the life sciences, I briefly discuss the diversity of different notions of the underlying levels metaphor. Before I turn to ontology research and Keet's formal theory of granularity, I introduce a specific notion of general building blocks, which gives rise to a hierarchy of levels of building blocks that is intended to function as an organizational backbone for integrating various granular perspectives that are relevant in the life sciences. Each such granular perspective employs its own specific application of the levels metaphor, which is integrated with the other perspectives within a general domain granularity framework for the life sciences. The resulting granularity framework is meant to provide the initial basis on which a desperately required overarching and more comprehensive information framework for the life sciences can be developed.

scholarly journals Levels and building blocks—towards a domain granularity framework for the life sciences

2017 ◽  
Author(s):  
Lars Vogt
Keyword(s):  
Life Sciences ◽  
Building Blocks ◽  
Formal Ontology ◽  
Basic Formal Ontology ◽  
Online Data ◽  
Data Repositories ◽  
Comprehensive Information ◽  
Material Entity ◽  
Information Framework ◽  
Require Data

The use of online data repositories and the establishment of new data standards that require data to be computer-parsable so that algorithms can reason over them have become increasingly important with the emergence of high-throughput technologies, Big Data and eScience. As a consequence, there is an increasing need for new approaches for organizing and structuring data from various sources into integrated hierarchies of levels of entities that facilitate algorithm-based approaches for data exploration, data comparison and analysis. In this paper I contrast various accounts of the level idea and resulting hierarchies published by philosophers and natural scientists with the more formal approaches of theories of granularity published by information scientists and ontology researchers. I discuss the shortcomings of the former and argue that the general theory of granularity proposed by Keet circumvents these problems and allows the integration of various different hierarchies into a domain granularity framework. I introduce the concept of general building blocks, which gives rise to a hierarchy of levels that can be formally characterized by Keet's theory. This hierarchy functions as an organizational backbone for integrating various other hierarchies that I briefly discuss, resulting in a general domain granularity framework for the life sciences. I also discuss the implicit consequences of this granularity framework for the structure of top-level categories of 'material entity' of the Basic Formal Ontology. The here suggested domain granularity framework is meant to provide the basis on which a more comprehensive information framework for the life sciences can be developed.

scholarly journals Levels and building blocks—towards a domain granularity framework for the life sciences

2017 ◽  
Author(s):  
Lars Vogt
Keyword(s):  
Life Sciences ◽  
Building Blocks ◽  
Formal Ontology ◽  
Basic Formal Ontology ◽  
Online Data ◽  
Data Repositories ◽  
Comprehensive Information ◽  
Material Entity ◽  
Information Framework ◽  
Require Data

The use of online data repositories and the establishment of new data standards that require data to be computer-parsable so that algorithms can reason over them have become increasingly important with the emergence of high-throughput technologies, Big Data and eScience. As a consequence, there is an increasing need for new approaches for organizing and structuring data from various sources into integrated hierarchies of levels of entities that facilitate algorithm-based approaches for data exploration, data comparison and analysis. In this paper I contrast various accounts of the level idea and resulting hierarchies published by philosophers and natural scientists with the more formal approaches of theories of granularity published by information scientists and ontology researchers. I discuss the shortcomings of the former and argue that the general theory of granularity proposed by Keet circumvents these problems and allows the integration of various different hierarchies into a domain granularity framework. I introduce the concept of general building blocks, which gives rise to a hierarchy of levels that can be formally characterized by Keet's theory. This hierarchy functions as an organizational backbone for integrating various other hierarchies that I briefly discuss, resulting in a general domain granularity framework for the life sciences. I also discuss the implicit consequences of this granularity framework for the structure of top-level categories of 'material entity' of the Basic Formal Ontology. The here suggested domain granularity framework is meant to provide the basis on which a more comprehensive information framework for the life sciences can be developed.

UNIVERSALITAS KETAUHIDAN TUHAN

2020 ◽  
Vol 15 (2) ◽  
pp. 379-403
Author(s):  
Roudhotul Jannah
Keyword(s):  
Oral Communication ◽  
The Other ◽  
Objective Data ◽  
Negotiation Strategy ◽  
Written Text ◽  
Comprehensive Information ◽  
Islamic Religion ◽  
New View ◽  
Qur'anic Interpretation

This article is about Angelika Neuwirth’s thought, dialectical of Qur’anic interpretation. She offer new view to understanding of Qur’an’s meaning. Neuwirth encourage to reunderstanding Qur’an post-canonization (a written text) with pre-canonization method (oral communication), as in Surat Al-Ikhlas. Accourding Neuwirth, Surat Al-Ikhlas responded from tradition and civilization of Arabic region earlier. An example أَحَدٌ (Q.112:1) is similiar meaning with “ehad” in Ibrani language. That’s mean usage أَحَدٌ had purpose to negotiation strategy and universality of faith. therefore Islamic religion has mission to combine all ideology of faith become unity universality. Neuwirth encourages to refer to the other holy scripture for adding comprehensive information and objective data.

Improvement of Gain Accuracy and CMRR of Low Power Instrumentation Amplifier Using High Gain Operational Amplifiers

2020 ◽  
Vol 12 (3) ◽  
pp. 168-174
Author(s):  
Rashmi Sahu ◽  
Maitraiyee Konar ◽  
Sudip Kundu
Keyword(s):  
Low Power ◽  
Building Blocks ◽  
High Gain ◽  
The Other ◽  
Operational Amplifiers ◽  
Instrumentation Amplifier ◽  
Biomedical Signals ◽  
Op Amp ◽  
Op Amps ◽  
Multi Stage

Background: Sensing of biomedical signals is crucial for monitoring of various health conditions. These signals have a very low amplitude (in μV) and a small frequency range (<500 Hz). In the presence of various common-mode interferences, biomedical signals are difficult to detect. Instrumentation amplifiers (INAs) are usually preferred to detect these signals due to their high commonmode rejection ratio (CMRR). Gain accuracy and CMRR are two important parameters associated with any INA. This article, therefore, focuses on the improvement of the gain accuracy and CMRR of a low power INA topology. Objective: The objective of this article is to achieve high gain accuracy and CMRR of low power INA by having high gain operational amplifiers (Op-Amps), which are the building blocks of the INAs. Methods: For the implementation of the Op-Amps and the INAs, the Cadence Virtuoso tool was used. All the designs and implementation were realized in 0.18 μm CMOS technology. Results: Three different Op-Amp topologies namely single-stage differential Op-Amp, folded cascode Op-Amp, and multi-stage Op-Amp were implemented. Using these Op-Amp topologies separately, three Op-Amp-based INAs were realized and compared. The INA designed using the high gain multistage Op-Amp topology of low-frequency gain of 123.89 dB achieves a CMRR of 164.1 dB, with the INA’s gain accuracy as good as 99%, which is the best when compared to the other two INAs realized using the other two Op-Amp topologies implemented. Conclusion: Using very high gain Op-Amps as the building blocks of the INA improves the gain accuracy of the INA and enhances the CMRR of the INA. The three Op-Amp-based INA designed with the multi-stage Op-Amps shows state-of-the-art characteristics as its gain accuracy is 99% and CMRR is as high as 164.1 dB. The power consumed by this INA is 29.25 μW by operating on a power supply of ±0.9V. This makes this INA highly suitable for low power measurement applications.

scholarly journals Language Family Engineering with Product Lines of Multi-level Models

2021 ◽  
Author(s):  
Juan de Lara ◽  
Esther Guerra
Keyword(s):  
Software Engineering ◽  
Arbitrary Number ◽  
Formal Theory ◽  
The Other ◽  
Language Family ◽  
Top Down ◽  
Product Lines ◽  
Modelling Languages ◽  
Multi Level ◽  
Definition Of

AbstractModelling is an essential activity in software engineering. It typically involves two meta-levels: one includes meta-models that describe modelling languages, and the other contains models built by instantiating those meta-models. Multi-level modelling generalizes this approach by allowing models to span an arbitrary number of meta-levels. A scenario that profits from multi-level modelling is the definition of language families that can be specialized (e.g., for different domains) by successive refinements at subsequent meta-levels, hence promoting language reuse. This enables an open set of variability options given by all possible specializations of the language family. However, multi-level modelling lacks the ability to express closed variability regarding the availability of language primitives or the possibility to opt between alternative primitive realizations. This limits the reuse opportunities of a language family. To improve this situation, we propose a novel combination of product lines with multi-level modelling to cover both open and closed variability. Our proposal is backed by a formal theory that guarantees correctness, enables top-down and bottom-up language variability design, and is implemented atop the MetaDepth multi-level modelling tool.

scholarly journals 2-Fluoromalonate Esters: Fluoroaliphatic Building Blocks for the Life Sciences

2014 ◽  
Vol 18 (8) ◽  
pp. 981-992 ◽  
Author(s):  
Antal Harsanyi ◽  
Graham Sandford
Keyword(s):  
Life Sciences ◽  
Building Blocks

A new three-dimensional anionic cadmium(II) dicyanamide network

2014 ◽  
Vol 70 (11) ◽  
pp. 1054-1056 ◽  
Author(s):  
Qiang Li ◽  
Hui-Ting Wang
Keyword(s):  
Crystal Structure ◽  
Aqueous Solution ◽  
Unit Cell Volume ◽  
Three Dimensional ◽  
Building Blocks ◽  
The Other ◽  
Dimensional Structure ◽  
Cadmium Nitrate ◽  
Nitrate Tetrahydrate ◽  
Anionic Framework

A new cadmium dicyanamide complex, poly[tetramethylphosphonium [μ-chlorido-di-μ-dicyanamido-κ4N1:N5-cadmium(II)]], [(CH3)4P][Cd(NCNCN)2Cl], was synthesized by the reaction of tetramethylphosphonium chloride, cadmium nitrate tetrahydrate and sodium dicyanamide in aqueous solution. In the crystal structure, each CdIIatom is octahedrally coordinated by four terminal N atoms from four anionic dicyanamide (dca) ligands and by two chloride ligands. The dicyanamide ligands play two different roles in the building up of the structure; one role results in the formation of [Cd(dca)Cl]2building blocks, while the other links the building blocks into a three-dimensional structure. The anionic framework exhibits a solvent-accessible void of 673.8 Å3, amounting to 47.44% of the total unit-cell volume. The cavities in the network are occupied by pairs of tetramethylphosphonium cations.

Invisible Architectures

2000 ◽  
Vol 13 (1) ◽  
pp. 121-136 ◽  
Author(s):  
Hans-Jörg Rheinberger
Keyword(s):  
Nineteenth Century ◽  
Seventeenth Century ◽  
Historical Development ◽  
Basic Problem ◽  
Life Sciences ◽  
The Other ◽  
Modern Life ◽  
Historical Process ◽  
Strategy I ◽  
The Invisible

The ArgumentIn this essay I will sketch a few instances of how, and a few forms in which, the “invisible” became an epistemic category in the development of the life sciences from the seventeenth century through the end of the nineteenth century. In contrast to most of the other papers in this issue, I do not so much focus on the visualization of various little entities, and the tools and contexts in which a visual representation of these things was realized. I will be more concerned with the basic problem of introducing entities or structures that cannot be seen, as elements of an explanatory strategy. I will try to review the ways in which the invisibility of such entities moved from the unproblematic status of just being too small to be accessible to the naked or even the armed eye, to the problematic status of being invisible in principle and yet being indispensable within a given explanatory framework. The epistemological concern of the paper is thus to sketch the historical process of how the “unseen” became a problem in the modern life sciences. The coming into being of the invisible as a space full of paradoxes is itself the product of a historical development that still awaits proper reconstruction.

Developing a Competitive City through Healthy Decision-Making

2012 ◽  
pp. 808-822
Author(s):  
Ori Gudes ◽  
Elizabeth Kendall ◽  
Tan Yigitcanlar ◽  
Jung Hoon Han ◽  
Virendra Pathak
Keyword(s):  
Decision Making ◽  
Decision Support ◽  
Information Science ◽  
Health Planning ◽  
Healthy City ◽  
Web Based ◽  
Comprehensive Information ◽  
Challenges And Opportunities ◽  
Planning Methods ◽  
Information Framework

This chapter investigates the challenges and opportunities associated with planning for a competitive city. The chapter is based on the assumption that a healthy city is a fundamental prerequisite for a competitive city. Thus, it is critical to examine the local determinants of health and factor these into any planning efforts. The main focus of the chapter is on e-health planning by utilising Web-based geographic decision support systems. The proposed novel decision support system would provide a powerful and effective platform for stakeholders to access essential data for decision-making purposes. The chapter also highlights the need for a comprehensive information framework to guide the process of planning for healthy cities. Additionally, it discusses the prospects and constraints of such an approach. In summary, this chapter outlines the potential insights of using an information science-based framework and suggests practical planning methods as part of a broader e-health approach for improving the health characteristics of competitive cities.

Policy in palliative care

2021 ◽  
pp. 26-32
Author(s):  
Stephen R. Connor
Keyword(s):  
Public Health ◽  
Palliative Care ◽  
National Policy ◽  
Building Blocks ◽  
The Other ◽  
World Health ◽  
Public Health Model ◽  
The World ◽  
Care Policies ◽  
Health Model

This chapter describes all aspects of policy, including definitions, who is it that sets policy, how policy is made, how policy is implemented, the elements of effective policies, the differences between policies and regulations, the policies that are important for palliative care, global versus national policy differences, and barriers to the creation and implementation of palliative care policies. Understanding policy is important, as it is one of the fundamental building blocks of palliative care under the World Health Organization’s public health model. This model underscores the pre-eminence of policy, as it makes possible all the other elements. Palliative care professionals should understand the complexity inherent in policy and embrace it as an important area to master.

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