The possible protective effect of Coriandrum sativum seeds methanolic extract on hepato-renal toxicity induced by sodium arsenite in albino rats

2014 ◽  
Keyword(s):  
Protective Effect ◽  
Sodium Arsenite ◽  
Renal Toxicity ◽  
Methanolic Extract ◽  
Coriandrum Sativum ◽  
Albino Rats

scholarly journals Evaluation of antidiabetic activity of fruit of Coriandrum sativum. Linn methanolic extract in Streptozocin induced diabetic wistar Albino rats

2017 ◽  
Vol 7 (1) ◽  
pp. 121
Author(s):  
Ahmed S. K. ◽  
Chakrapani Cheekavolu ◽  
Sampath D. ◽  
Sunil M.
Keyword(s):  
Research Study ◽  
Diabetes Management ◽  
Methanolic Extract ◽  
Coriandrum Sativum ◽  
Antidiabetic Activity ◽  
Control Group ◽  
Albino Rats ◽  
Citrate Buffer ◽  
Standard Drug ◽  
Wistar Albino Rats

Background: Diabetes prevalence is estimated to increase annually. Numerous people use traditional medicine, such as India also considered as the diabetic capital in the world. Diabetes is a metabolic disorder characterized by disturbances in lipid, carbohydrate and protein metabolism. The present study to evaluate the antidiabetic potential of coriandrum sativum. linn fruits methanolic extract in streptozocin induced diabetic wistar albino rats model.Methods: Diabetes induction in wistar albino rats by administration of streptozocin (50mg/kg, i.p.) in citrate buffer. 30 wistar albino rats were divided into 5 groups (A, B, C, D, E). Group A: served as normal control, whereas Group B: diabetic control, Group C, D methanolic coriandrum sativum Linn. fruits extract (CSFME) at a dose of 100, 200mg/kg orally, Group E was given standard drug Glibenclamide (0.5mg/kg) orally. All groups are administered for the period of 14 consecutive days and blood sugar levels was measured at regular intervals up to end of the study.Results: This present research study confirms that the test drug compound CSFME has sustained oral hypoglycaemic activity and statistically significant (p ≤0.05) and which is comparable with standard drug Glibenclamide.Conclusions: This research study confirms that the CSFME has antidiabetic activity against streptozocin induced wistar diabetic albino rats. It could be a novel antidiabetic agent and also a dietary adjunct in the type 2 diabetes management and its complication. Further studies are necessary required to confirm the antidiabetic activity of individual phytochemical compounds of Coriandrum sativum.

scholarly journals Protective effect of starch-stabilized selenium nanoparticles against melamine-induced hepato-renal toxicity in male albino rats

2021 ◽  
Author(s):  
Zainab Sabry Othman Ahmed ◽  
Mona K. Galal ◽  
Elsayed A. Drweesh ◽  
Khaled S. Abou-El-Sherbini ◽  
Eman A.M. Elzahany ◽  
...  
Keyword(s):  
Protective Effect ◽  
Renal Toxicity ◽  
Selenium Nanoparticles ◽  
Albino Rats

scholarly journals Cisplatin Nephrotoxicity and Protection by Milk Thistle Extract in Rats

2005 ◽  
Vol 2 (3) ◽  
pp. 383-386 ◽  
Author(s):  
Gholamreza Karimi ◽  
Mohammad Ramezani ◽  
Zahra Tahoonian
Keyword(s):  
Serum Creatinine ◽  
Protective Effect ◽  
Renal Toxicity ◽  
Methanolic Extract ◽  
Male Rats ◽  
Milk Thistle ◽  
Tubular Damage ◽  
Cisplatin Nephrotoxicity ◽  
Tubular Necrosis ◽  
Single Intraperitoneal Injection

The protective effect of methanolic extract of milk thistle seeds and silymarin against cisplatin-induced renal toxicity in male rats after a single intraperitoneal injection of 3 mg kg−1 cisplatin were studied. Over 5 days, cisplatin-treated rats showed tubular necrosis and elevation in blood urea nitrogen (BUN) and serum creatinine (Scr). Pretreatment of animals with silymarin (50 mg kg−1) or extract (0.6 g kg−1) 2 h before cisplatin prevented the tubular damage. Rats treated with silymarin or extract 2 h after cisplatin had BUN and Scr significantly lower than those receiving cisplatin, but mild to moderate necrosis was observed. These results suggested that milk thistle may protect against cisplatin-induced renal toxicity and might serve as a novel combination agent with cisplatin to limit renal injury.

scholarly journals The Protective Effect of Croton zambesicus against Carbon Tetrachloride-induced Renal Toxicity in Rats

2019 ◽  
Vol 13 (1) ◽  
pp. 5-8
Author(s):  
Rashidat Oluwafunke Ayanniyi ◽  
◽  
Hidayah Ayodeji Olumoh-Abdul ◽  
Fatimoh Idowu Ojuade ◽  
Rasheed Abdullahi ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Kidney Disease ◽  
Protective Effect ◽  
Leaf Extract ◽  
Renal Toxicity ◽  
Kidney Tissue ◽  
Albino Rats ◽  
Serum Electrolytes ◽  
Butanol Fraction ◽  
Aqueous Leaf Extract

Background: The leaf extract of Croton zambesicus (CZ) is used in traditional medicine for the management of various conditions including kidney disease. The purpose of this study was to determine the protective effects of leaf extract of CZ on rat kidney toxicity induced by carbon tetrachloride. Method: Male albino rats were divided into 6 groups of 5 rats and treated for 5 days with aqueous extract (200-400 mg/kg) and n-butanol fraction (20-40 mg/kg) of CZ. Carbon tetrachloride (2 ml/kg of 40% in olive oil) was administered subcutaneously for 3 days and the rats were treated with the extract and fraction for 3 days. Animals were euthanized on day 8 with intraperitoneal injection of ketamine (60 mg/kg) and xylazine (7.5 mg/kg). Blood sample was collected for the analysis of serum electrolytes, urea and creatinine. Kidney tissue was harvested to determine the antioxidant enzyme activity. Results: Carbon tetrachloride produced increased serum sodium ion, chloride ion, urea and creatinine with decreased superoxide, catalase, glutathione, oxidized glutathione and an increase in malondialdehyde concentration. Treatment of rats with the aqueous leaf extract and n-butanol fraction attenuated the toxic effects of carbon tetrachloride on kidney with a significant decline in serum electrolytes, urea, creatinine and a significant increase in the concentration of antioxidant enzymes. Conclusion: Results from this study revealed that the aqueous leaf extract and n-butanol fraction of CZ had protective effect against carbon tetrachloride-induced renal toxicity in rats, thus justifying the consideration of this plant for the management of kidney disease.

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