scholarly journals Estimating the impact of universal antiretroviral therapy for HIV serodiscordant couples through home HIV testing: insights from mathematical models

2016 ◽  
Vol 19 (1) ◽  
pp. 20864 ◽  
Author(s):  
Sarah T Roberts ◽  
Aditya S Khanna ◽  
Ruanne V Barnabas ◽  
Steven M Goodreau ◽  
Jared M Baeten ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Mathematical Models ◽  
Hiv Testing ◽  
Serodiscordant Couples ◽  
Hiv Serodiscordant Couples ◽  
The Impact

Young Adulthood and Serodiscordant Couples

2017 ◽  
Author(s):  
Marshall Forstein ◽  
Farah Ahmad-Stout ◽  
Gaddy Noy
Keyword(s):  
Social Networks ◽  
Young Adults ◽  
Antiretroviral Therapy ◽  
Serodiscordant Couples ◽  
Extended Families ◽  
Need Support ◽  
Serological Status ◽  
Exposure Prophylaxis ◽  
The Impact ◽  
Hiv Negative

Advances in HIV medical care and antiretroviral therapy transformed AIDS from a rapidly devastating fatal illness into a chronic illness for persons with access to care, leading to vast changes in the health of individuals, couples, their children, extended families, and social networks. In addition, adherence to antiretroviral therapy and viral suppression have reduced the likelihood of transmission of HIV, and the use of pre-exposure prophylaxis (PrEP) in an HIV-negative partner offers an additional option to prevent seroconversion. Significant biopsychosocial challenges remain, however, for couples who are dissimilar (serodiscordant) in HIV serological status and young adults with HIV. Many young adults and serodiscordant couples who are engaged in care and virally suppressed need support as they plan to have children or re-enter careers and social networks. There are few studies of couples with similar (seroconcordant) or serodiscordant HIV serological status. This chapter focuses on the impact of HIV on serodiscordant couples in which only one member is infected. After reviewing some of the literature, clinical issues that emerge in evaluating and treating couples are presented.

Natural Conception is Safe for HIV-Serodiscordant Couples with Persistent Suppressive Antiretroviral Therapy for the Infected Partner

2019 ◽  
Vol 28 (11) ◽  
pp. 1555-1562 ◽  
Author(s):  
María Begoña Baza ◽  
Adrian Jerónimo ◽  
Isabel Río ◽  
Carmen Rodriguez ◽  
Mar Vera ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Serodiscordant Couples ◽  
Hiv Serodiscordant Couples ◽  
Infected Partner ◽  
Natural Conception

scholarly journals Modelling the impact and cost-effectiveness of combination prevention amongst HIV serodiscordant couples in Nigeria

AIDS ◽  
2015 ◽  
Vol 29 (15) ◽  
pp. 2035-2044 ◽  
Author(s):  
Kate M. Mitchell ◽  
Aurélia Lépine ◽  
Fern Terris-Prestholt ◽  
Kwasi Torpey ◽  
Hadiza Khamofu ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Serodiscordant Couples ◽  
Combination Prevention ◽  
Hiv Serodiscordant Couples ◽  
The Impact

scholarly journals Natural conception in HIV-serodiscordant couples with the infected partner in suppressive antiretroviral therapy

Medicine ◽  
2016 ◽  
Vol 95 (30) ◽  
pp. e4398 ◽  
Author(s):  
Jorge Del Romero ◽  
María Begoña Baza ◽  
Isabel Río ◽  
Adrián Jerónimo ◽  
Mar Vera ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Serodiscordant Couples ◽  
Hiv Serodiscordant Couples ◽  
Infected Partner ◽  
Natural Conception

Natural Pregnancies in HIV-Serodiscordant Couples Receiving Successful Antiretroviral Therapy

2006 ◽  
Vol 43 (3) ◽  
pp. 324-326 ◽  
Author(s):  
Pablo Barreiro ◽  
Jorge del Romero ◽  
Manuel Leal ◽  
Victoria Hernando ◽  
Rom??n Asencio ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Serodiscordant Couples ◽  
Hiv Serodiscordant Couples

scholarly journals Efficient Identification of HIV Serodiscordant Couples by Existing HIV Testing Programs in South Brazil

PLoS ONE ◽  
2015 ◽  
Vol 10 (11) ◽  
pp. e0142638 ◽  
Author(s):  
Christopher D. Pilcher ◽  
Claudia Alquati Bisol ◽  
Machline Paim Paganella ◽  
Snigdha Vallabhaneni ◽  
Leonardo Rapone da Motta ◽  
...  
Keyword(s):  
Hiv Testing ◽  
Serodiscordant Couples ◽  
Hiv Serodiscordant Couples ◽  
South Brazil

scholarly journals STING and cGAS gene expressions were downregulated among HIV-1-infected persons after antiretroviral therapy

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Lorena Leticia Peixoto de Lima ◽  
Allysson Quintino Tenório de Oliveira ◽  
Tuane Carolina Ferreira Moura ◽  
Ednelza da Silva Graça Amoras ◽  
Sandra Souza Lima ◽  
...  
Keyword(s):  
Gene Expression ◽  
Viral Load ◽  
T Cell ◽  
Antiretroviral Therapy ◽  
Cell Count ◽  
Enzyme Linked Immunosorbent Assay ◽  
Type I ◽  
Α Level ◽  
The Impact ◽  
Hiv 1

Abstract Background The HIV-1 epidemic is still considered a global public health problem, but great advances have been made in fighting it by antiretroviral therapy (ART). ART has a considerable impact on viral replication and host immunity. The production of type I interferon (IFN) is key to the innate immune response to viral infections. The STING and cGAS proteins have proven roles in the antiviral cascade. The present study aimed to evaluate the impact of ART on innate immunity, which was represented by STING and cGAS gene expression and plasma IFN-α level. Methods This cohort study evaluated a group of 33 individuals who were initially naïve to therapy and who were treated at a reference center and reassessed 12 months after starting ART. Gene expression levels and viral load were evaluated by real-time PCR, CD4+ and CD8+ T lymphocyte counts by flow cytometry, and IFN-α level by enzyme-linked immunosorbent assay. Results From before to after ART, the CD4+ T cell count and the CD4+/CD8+ ratio significantly increased (p < 0.0001), the CD8+ T cell count slightly decreased, and viral load decreased to undetectable levels in most of the group (84.85%). The expression of STING and cGAS significantly decreased (p = 0.0034 and p = 0.0001, respectively) after the use of ART, but IFN-α did not (p = 0.1558). Among the markers evaluated, the only markers that showed a correlation with each other were STING and CD4+ T at the time of the first collection. Conclusions ART provided immune recovery and viral suppression to the studied group and indirectly downregulated the STING and cGAS genes. In contrast, ART did not influence IFN-α. The expression of STING and cGAS was not correlated with the plasma level of IFN-α, which suggests that there is another pathway regulating this cytokine in addition to the STING–cGAS pathway.

Assessing antiretroviral therapy success in HIV/AIDS morbidity and mortality trends in Brazil, 1990–2017: an interrupted time series study

2020 ◽  
pp. 095646242095298
Author(s):  
Augusto Cesar Lara de Sousa ◽  
Tatiana de Araujo Eleuterio ◽  
José Victor Afonso Coutinho ◽  
Raphael Mendonça Guimarães
Keyword(s):  
Time Series ◽  
Antiretroviral Therapy ◽  
Burden Of Disease ◽  
Interrupted Time Series ◽  
People Living With Hiv ◽  
Disability Adjusted Life Years ◽  
Disability Adjusted Life ◽  
Life Years ◽  
The Impact ◽  
Hiv Aids

To describe the trends of HIV/AIDS metrics related to the burden of disease for Brazil between 1990 and 2017 we conducted a timeseries analysis for HIV/AIDS indicators by extracting data from the Global Burden of Disease study. We calculated traditional prevalence, incidence and mortality rates, the number of years lost by HIV-related deaths (YLL) and disability (YLD), and disability-adjusted life years (DALY). We estimated time series models and assessed the impact of highly active antiretroviral therapy (HAART) on the same indicators. In the set of disability-adjusted life years (DALY), the highest weight of its magnitude was due to YLL. There was a decline, especially after 1996, of DALY, mortality and YLL for HIV/AIDS. However, YLD, incidence, and prevalence increased over the same period. Also, the analysis of interrupted time series showed that the introduction of HAART into health policy had a significant impact on indicators, especially for DALY and YLL. We need to assess the quality of life of people living with HIV, especially among older adults. In addition, we need to focus on primary prevention, emphasizing methods to avoid infection and public policies should reflect this.

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