Social Isolation and Cardiovascular Disease: An Atherosclerotic Pathway?

2002 ◽  
Keyword(s):  
Cardiovascular Disease ◽  
Social Isolation

scholarly journals Loneliness, social isolation, cardiovascular disease and mortality: a synthesis of the literature and conceptual framework

2020 ◽  
Vol 113 (5) ◽  
pp. 185-192 ◽  
Author(s):  
Sam Hodgson ◽  
Isabella Watts ◽  
Simon Fraser ◽  
Paul Roderick ◽  
Hajira Dambha-Miller
Keyword(s):  
Systematic Review ◽  
Cardiovascular Disease ◽  
Health Outcomes ◽  
Conceptual Framework ◽  
Social Isolation ◽  
English Language ◽  
Qualitative Studies ◽  
Socially Isolated ◽  
Poor Outcomes

To conduct a systematic review and develop a conceptual framework on the mechanisms linking loneliness, social isolation, health outcomes and mortality. Electronic databases were systematically searched (PubMed, MEDLINE, Scopus and EMBASE) from inception to October 2018 followed by manual searching to identify research on loneliness, social isolation and mortality in adults published in the English language. Articles were assessed for quality and synthesised into a conceptual framework using meta-ethnographical approaches. A total of 122 articles were included. These collated observational designs examining mediators and moderations of the association in addition to qualitative studies exploring potential mechanisms were included. A framework incorporating 18 discrete factors implicated in the association between loneliness, social isolation and mortality was developed. Factors were categorised into societal or individual, and sub-categorised into biological, behavioural and psychological. These findings emphasise the complex multidirectional relationship between loneliness, social isolation and mortality. Our conceptual framework may allow development of more holistic interventions, targeting many of the interdependent factors that contribute to poor outcomes for lonely and socially isolated people.

scholarly journals Chronic social isolation in the prairie vole induces endothelial dysfunction: implications for depression and cardiovascular disease

2012 ◽  
Vol 106 (4) ◽  
pp. 476-484 ◽  
Author(s):  
Jacob D. Peuler ◽  
Melissa-Ann L. Scotti ◽  
Laura E. Phelps ◽  
Neal McNeal ◽  
Angela J. Grippo
Keyword(s):  
Cardiovascular Disease ◽  
Endothelial Dysfunction ◽  
Social Isolation ◽  
Prairie Vole

SOCIAL ISOLATION AND CARDIOVASCULAR DISEASE: AN ATHEROSCLEROTIC PATHWAY?

1998 ◽  
Vol 23 (8) ◽  
pp. 877-890 ◽  
Author(s):  
Sarah S Knox ◽  
Kerstin Uvnäs-Moberg
Keyword(s):  
Cardiovascular Disease ◽  
Social Isolation

scholarly journals Social isolation during the COVID-19 pandemic can increase physical inactivity and the global burden of cardiovascular disease

2020 ◽  
Vol 318 (6) ◽  
pp. H1441-H1446 ◽  
Author(s):  
Tiago Peçanha ◽  
Karla Fabiana Goessler ◽  
Hamilton Roschel ◽  
Bruno Gualano
Keyword(s):  
Physical Activity ◽  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
Sedentary Behavior ◽  
Social Isolation ◽  
Physical Inactivity ◽  
Global Burden ◽  
Activity Levels ◽  
Home Based ◽  
Physical Activity Levels

Emerging data indicate a substantial decrease in global physical activity levels during the period of social isolation adopted worldwide to contain the spread of the coronavirus disease 2019 (COVID-19). Confinement-induced decreases in physical activity levels and increases in sedentary behavior may provoke a rapid deterioration of cardiovascular health and premature deaths among populations with increased cardiovascular risk. Even short-term (1–4 wk) inactivity has been linked with detrimental effects in cardiovascular function and structure and increased cardiovascular risk factors. In this unprecedented and critical scenario, home-based physical activity programs arise as a clinically relevant intervention to promote health benefits to cardiac patients. Many studies have demonstrated the feasibility, safety, and efficacy of different models of home-based exercise programs in the primary and secondary prevention of cardiovascular diseases and major cardiovascular events among different populations. This body of knowledge can inform evidence-based policies to be urgently implemented to counteract the impact of increased physical inactivity and sedentary behavior during the COVID-19 outbreak, thereby alleviating the global burden of cardiovascular disease.

scholarly journals 24-Hour Autonomic Dysfunction and Depressive Behaviors in an Animal Model of Social Isolation: Implications for the Study of Depression and Cardiovascular Disease

2011 ◽  
Vol 73 (1) ◽  
pp. 59-66 ◽  
Author(s):  
Angela J. Grippo ◽  
C. Sue Carter ◽  
Neal McNeal ◽  
Danielle L. Chandler ◽  
Meagan A. LaRocca ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Animal Model ◽  
Social Isolation ◽  
Autonomic Dysfunction

scholarly journals Loneliness, social isolation and risk of cardiovascular disease in the English Longitudinal Study of Ageing

2018 ◽  
Vol 25 (13) ◽  
pp. 1387-1396 ◽  
Author(s):  
Nicole K Valtorta ◽  
Mona Kanaan ◽  
Simon Gilbody ◽  
Barbara Hanratty
Keyword(s):  
Cardiovascular Disease ◽  
Social Isolation ◽  
Social Relationships ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Increased Risk ◽  
Incident Cardiovascular Disease ◽  
English Longitudinal Study ◽  
Over Time

Background There is increasing evidence of an association between social relationships and morbidity in general, and cardiovascular disease in particular. However, recent syntheses of the evidence raise two important questions: is it the perceived quality or the more objective quantity of relationships that matters most; and what are the implications of changes in relationships over time? In this study, we investigate the cumulative effects of loneliness and social isolation on incident cardiovascular disease. Design A secondary analysis of prospective follow-up data from the English Longitudinal Study of Ageing (ELSA). Methods To assess the association between social isolation or loneliness and incident cardiovascular disease, lagged values of exposure to loneliness and isolation were treated as time-varying variables in discrete time survival models controlling for potential confounders and established cardiovascular disease risk factors. Results A total of 5397 men and women aged over 50 years were followed up for new fatal and non-fatal diagnoses of heart disease and stroke between 2004 and 2010. Over a mean follow-up period of 5.4 years, 571 new cardiovascular events were recorded. We found that loneliness was associated with an increased risk of cardiovascular disease (odds ratio 1.27, 95% confidence interval 1.01–1.57). Social isolation, meanwhile, was not associated with disease incidence. There was no evidence of a cumulative effect over time of social relationships on cardiovascular disease risk. Conclusions Loneliness is associated with an increased risk of developing coronary heart disease and stroke, independently of traditional cardiovascular disease risk factors. Our findings suggest that primary prevention strategies targeting loneliness could help to prevent cardiovascular disease.

scholarly journals LONELINESS, SOCIAL ISOLATION AND CARDIOVASCULAR DISEASE: EFFECTS OVER TIME IN ENGLISH OLDER ADULTS

2017 ◽  
Vol 1 (suppl_1) ◽  
pp. 952-953
Author(s):  
N. Valtorta ◽  
M. Kanaan ◽  
S. Gilbody ◽  
B. Hanratty
Keyword(s):  
Cardiovascular Disease ◽  
Older Adults ◽  
Social Isolation ◽  
Over Time
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