scholarly journals Author response: Epigenetic regulation of lateralized fetal spinal gene expression underlies hemispheric asymmetries

2017 ◽  
Author(s):  
Sebastian Ocklenburg ◽  
Judith Schmitz ◽  
Zahra Moinfar ◽  
Dirk Moser ◽  
Rena Klose ◽  
...  
Keyword(s):  
Gene Expression ◽  
Epigenetic Regulation ◽  
Author Response ◽  
Hemispheric Asymmetries

scholarly journals Epigenetic regulation of lateralized fetal spinal gene expression underlies hemispheric asymmetries

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Sebastian Ocklenburg ◽  
Judith Schmitz ◽  
Zahra Moinfar ◽  
Dirk Moser ◽  
Rena Klose ◽  
...  
Keyword(s):  
Gene Expression ◽  
Spinal Cord ◽  
Epigenetic Regulation ◽  
Molecular Basis ◽  
Molecular Mechanisms ◽  
Cpg Islands ◽  
Fundamental Principle ◽  
Human Fetuses ◽  
Hemispheric Asymmetries ◽  
Starting Point

Lateralization is a fundamental principle of nervous system organization but its molecular determinants are mostly unknown. In humans, asymmetric gene expression in the fetal cortex has been suggested as the molecular basis of handedness. However, human fetuses already show considerable asymmetries in arm movements before the motor cortex is functionally linked to the spinal cord, making it more likely that spinal gene expression asymmetries form the molecular basis of handedness. We analyzed genome-wide mRNA expression and DNA methylation in cervical and anterior thoracal spinal cord segments of five human fetuses and show development-dependent gene expression asymmetries. These gene expression asymmetries were epigenetically regulated by miRNA expression asymmetries in the TGF-β signaling pathway and lateralized methylation of CpG islands. Our findings suggest that molecular mechanisms for epigenetic regulation within the spinal cord constitute the starting point for handedness, implying a fundamental shift in our understanding of the ontogenesis of hemispheric asymmetries in humans.

scholarly journals Epigenetic Regulation of Cytokine Gene Expression in T Lymphocytes

2009 ◽  
Vol 50 (3) ◽  
pp. 322 ◽  
Author(s):  
Choong-Gu Lee ◽  
Anupama Sahoo ◽  
Sin-Hyeog Im
Keyword(s):  
Gene Expression ◽  
T Lymphocytes ◽  
Epigenetic Regulation ◽  
Cytokine Gene Expression ◽  
Cytokine Gene

scholarly journals Publisher Correction to: C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formation

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Tatsuya Ozawa ◽  
Syuzo Kaneko ◽  
Frank Szulzewsky ◽  
Zhiwei Qiao ◽  
Mutsumi Takadera ◽  
...  
Keyword(s):  
Gene Expression ◽  
Epigenetic Regulation ◽  
Aberrant Gene Expression ◽  
Aberrant Gene

An amendment to this paper has been published and can be accessed via the original article.

scholarly journals Epigenetic regulation of gene expression in Chinese Hamster Ovary cells in response to the changing environment of a batch culture

2019 ◽  
Vol 116 (3) ◽  
pp. 677-692 ◽  
Author(s):  
Inmaculada Hernandez ◽  
Heena Dhiman ◽  
Gerald Klanert ◽  
Vaibhav Jadhav ◽  
Norbert Auer ◽  
...  
Keyword(s):  
Gene Expression ◽  
Batch Culture ◽  
Epigenetic Regulation ◽  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Regulation Of Gene Expression ◽  
Chinese Hamster ◽  
Changing Environment ◽  
Ovary Cells
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