scholarly journals MS Disease and Providing a Biologic Perspective and Reducing the Symptoms of the Disease with the Help of Stem Cells

2020 ◽  
Vol 8 (1) ◽  
pp. 6
Author(s):  
Ehsan Sharifipour ◽  
Hoorolnesa Ameli ◽  
Shima Sadat Hashemi Madani
Keyword(s):  
Stem Cells ◽  
Central Nervous System ◽  
Inflammatory Diseases ◽  
Repair Process ◽  
Bowel Dysfunction ◽  
Biological Properties ◽  
Complete Treatment ◽  
The Central Nervous System ◽  
Injection Methods ◽  
Treatment Category

Introduction: MS is one of the most common inflammatory diseases of the central nervous system, with the destruction of nerves. One of the symptoms of MS disorder is dystonia, fatigue, spasticity, disturbances, lack of sensation in the organs, cognitive impairment, weakness, tremor, pain, bladder and bowel dysfunction. Method: The search was carried out in the Pubmed/Medline database. 63 The study was designed to investigate patients with MS and therapeutic samples that were materially similar to the current research, and are included in this article. Findings: Therapeutic injection methods in MS have responded, but patients are still in trouble. Studies have shown that the use of stem cells for treating patients with MS has been fruitful and can be used to treat MS. Discussion: As it has been said, the most important treatment challenges in this way is to reduce treatment, and moreover, that anti-MS drugs in advanced forms are limited. Hence, the production of new, improved medicines for the complete treatment of MS is essential. Stem cells play a veryw important role in the repair process, and the complications of these cells are low in patients and provide an acceptable response. Reliably, the focus on new immunology methods with more biological properties has a greater impact on the treatment category. They will have patients.

Neural Stem Cells to Glial Cells an Important Factor for Brain Injury

2020 ◽  
Author(s):  
Prithiv K R Kumar
Keyword(s):  
Stem Cells ◽  
Central Nervous System ◽  
Nervous System ◽  
Neural Stem Cells ◽  
Glial Cells ◽  
Brain Injuries ◽  
The Body ◽  
The Central Nervous System ◽  
Near Future

Stem cells have the capacity to differentiate into any type of cell or organ. Stems cell originate from any part of the body, including the brain. Brain cells or rather neural stem cells have the capacitive advantage of differentiating into the central nervous system leading to the formation of neurons and glial cells. Neural stem cells should have a source by editing DNA, or by mixings chemical enzymes of iPSCs. By this method, a limitless number of neuron stem cells can be obtained. Increase in supply of NSCs help in repairing glial cells which in-turn heal the central nervous system. Generally, brain injuries cause motor and sensory deficits leading to stroke. With all trials from novel therapeutic methods to enhanced rehabilitation time, the economy and quality of life is suppressed. Only PSCs have proven effective for grafting cells into NSCs. Neurons derived from stem cells is the only challenge that limits in-vitro usage in the near future.

scholarly journals Plant Species of Sub-Family Valerianaceae—A Review on Its Effect on the Central Nervous System

Plants ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 846
Author(s):  
Gitishree Das ◽  
Han-Seung Shin ◽  
Rosa Tundis ◽  
Sandra Gonçalves ◽  
Ourlad Alzeus G. Tantengco ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Plant Species ◽  
Current Knowledge ◽  
Biological Properties ◽  
In Vivo Studies ◽  
Food Species ◽  
The Central Nervous System ◽  
Preclinical And Clinical Studies

Valerianaceae, the sub-family of Caprifoliaceae, contains more than 300 species of annual and perennial herbs, worldwide distributed. Several species are used for their biological properties while some are used as food. Species from the genus Valeriana have been used for their antispasmodic, relaxing, and sedative properties, which have been mainly attributed to the presence of valepotriates, borneol derivatives, and isovalerenic acid. Among this genus, the most common and employed species is Valerianaofficinalis. Although valerian has been traditionally used as a mild sedative, research results are still controversial regarding the role of the different active compounds, the herbal preparations, and the dosage used. The present review is designed to summarize and critically describe the current knowledge on the different plant species belonging to Valerianaceae, their phytochemicals, their uses in the treatment of different diseases with particular emphasis on the effects on the central nervous system. The available information on this sub-family was collected from scientific databases up until year 2020. The following electronic databases were used: PubMed, Scopus, Sci Finder, Web of Science, Science Direct, NCBI, and Google Scholar. The search terms used for this review included Valerianaceae, Valeriana, Centranthus, Fedia, Patrinia, Nardostachys, Plectritis, and Valerianella, phytochemical composition, in vivo studies, Central Nervous System, neuroprotective, antidepressant, antinociceptive, anxiolytic, anxiety, preclinical and clinical studies.

scholarly journals PTMAc-PEG-PTMAc hydrogel modified by RGDC and hyaluronic acid promotes neural stem cells' survival and differentiation in vitro

RSC Advances ◽  
2017 ◽  
Vol 7 (65) ◽  
pp. 41098-41104 ◽  
Author(s):  
Ruirui Yang ◽  
Caixia Xu ◽  
Tao Wang ◽  
Yuanqi Wang ◽  
Jingnan Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Central Nervous System ◽  
Nervous System ◽  
Hyaluronic Acid ◽  
Neural Stem Cells ◽  
Biological Properties ◽  
Central Nervous System Injury ◽  
Bioactive Molecules

The enhancement of the biological properties of hydrogels by surface modifying with bioactive molecules is of great significance, especially for the treatment of central nervous system injury by combining engrafted cells.

scholarly journals MicroRNA Signature in Human Normal and Tumoral Neural Stem Cells

2019 ◽  
Vol 20 (17) ◽  
pp. 4123 ◽  
Author(s):  
Diana ◽  
Gaido ◽  
Murtas
Keyword(s):  
Stem Cells ◽  
Central Nervous System ◽  
Nervous System ◽  
Neural Stem Cells ◽  
Mature Mirnas ◽  
Human Species ◽  
Cellular Context ◽  
The Central Nervous System ◽  
Non Coding Rnas ◽  
Insight Into

MicroRNAs, also called miRNAs or simply miR-, represent a unique class of non-coding RNAs that have gained exponential interest during recent years because of their determinant involvement in regulating the expression of several genes. Despite the increasing number of mature miRNAs recognized in the human species, only a limited proportion is engaged in the ontogeny of the central nervous system (CNS). miRNAs also play a pivotal role during the transition of normal neural stem cells (NSCs) into tumor-forming NSCs. More specifically, extensive studies have identified some shared miRNAs between NSCs and neural cancer stem cells (CSCs), namely miR-7, -124, -125, -181 and miR-9, -10, -130. In the context of NSCs, miRNAs are intercalated from embryonic stages throughout the differentiation pathway in order to achieve mature neuronal lineages. Within CSCs, under a different cellular context, miRNAs perform tumor suppressive or oncogenic functions that govern the homeostasis of brain tumors. This review will draw attention to the most characterizing studies dealing with miRNAs engaged in neurogenesis and in the tumoral neural stem cell context, offering the reader insight into the power of next generation miRNA-targeted therapies against brain malignances.

Ablation of Tumor-Derived Stem Cells Transplanted to the Central Nervous System by Genetic Modification of Embryonic Stem Cells with a Suicide Gene

2007 ◽  
Vol 18 (12) ◽  
pp. 1182-1192 ◽  
Author(s):  
Juyeon Jung ◽  
Neil R. Hackett ◽  
Robert G. Pergolizzi ◽  
Lorraine Pierre-Destine ◽  
Anja Krause ◽  
...  
Keyword(s):  
Stem Cells ◽  
Central Nervous System ◽  
Nervous System ◽  
Embryonic Stem Cells ◽  
Genetic Modification ◽  
Embryonic Stem ◽  
Suicide Gene ◽  
The Central Nervous System
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