scholarly journals Investigation of Various Green Chemistry Approaches for the Efficient Synthesis of Dialkyl-1, 4-dihydro-4-(substituted phenyl)-2, 6-dimethylpyridine-3, 5-dicarboxylate

2013 ◽  
Vol 2 (S1) ◽  
Keyword(s):  
Green Chemistry ◽  
Efficient Synthesis

scholarly journals Microwave-assisted Efficient Synthesis of Isatins and spiro-Thiadiazolines under Green Chemistry Protocol

2010 ◽  
Vol 2 (2) ◽  
pp. 322-329 ◽  
Author(s):  
M. M. Hossain ◽  
M. A. Foysal ◽  
M. Mahabub ◽  
Al- Amin
Keyword(s):  
Schiff Base ◽  
Green Chemistry ◽  
Schiff Bases ◽  
Aromatic Amines ◽  
Electrophilic Aromatic Substitution ◽  
Aromatic Substitution ◽  
Efficient Synthesis ◽  
Microwave Assisted ◽  
Primary Aromatic Amines ◽  
Mw Irradiation

MW-assisted treatment of oximinoacetanilides obtained from substituted primary aromatic amines was carried out in conc. H2SO4 medium for 5-10 sec to give cyclic amides (isatins) through intramolecular cyclization by means of electrophilic aromatic substitution. Isatins reacted with thiosemicarbazide under MW-condition gave the corresponding Schiff-bases. The Schiff-bases undergo cyclization in presence of minimal Ac2O under MW-irradiation for 3-4 min to give the spiro-thiadiazoline acetyl derivatives in excellent yield. Keywords:  Microwave-synthesis; Isatins; Schiff-base; spiro-Thiadiazoline; Green chemistry. © 2010 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.  DOI: 10.3329/jsr.v2i2.3731               J. Sci. Res. 2 (2), 322-329 (2010)  

scholarly journals Efficient synthesis of butyl levulinate from furfuryl alcohol over ordered mesoporous Ti-KIT-6 catalysts for green chemistry applications

RSC Advances ◽  
2017 ◽  
Vol 7 (87) ◽  
pp. 55206-55214 ◽  
Author(s):  
Jimmy Nelson Appaturi ◽  
Mohd Rafie Johan ◽  
R. Jothi Ramalingam ◽  
Hamad A. Al-Lohedan ◽  
J. Judith Vijaya
Keyword(s):  
Green Chemistry ◽  
Molecular Sieve ◽  
Furfuryl Alcohol ◽  
Sol Gel ◽  
Efficient Synthesis ◽  
Ordered Mesoporous ◽  
Gel Treatment

Here we describe the synthesis of butyl levulinate by alcoholysis of furfuryl alcohol with n-butanol over a series of titanium incorporated mesoporous KIT-6 molecular sieve catalysts prepared by a simple sol–gel treatment.

Green Synthesis of 4-aryl-3,4-Dihydrochromeno[3,4-e][1,3]Oxazine-2,5-Dione in Aqueous Media by Condensation of 4-Hydroxycoumarin with Aromatic Aldehydes and Methyl Carbamate

2017 ◽  
Vol 41 (3) ◽  
pp. 136-138 ◽  
Author(s):  
Sabereh Bougan ◽  
Alireza Hassanabadi
Keyword(s):  
Green Chemistry ◽  
Organic Solvent ◽  
Green Synthesis ◽  
Aqueous Media ◽  
Reaction Times ◽  
Aromatic Aldehydes ◽  
Efficient Synthesis ◽  
One Pot ◽  
Three Component Reaction ◽  
High Yields

A green and efficient synthesis of the title compounds has been achieved in a one-pot, three-component reaction of 4-hydroxycoumarin and aromatic aldehydes with methyl carbamate catalysed by p-toluenesulfonic acid in aqueous media to afford 4-aryl-3,4-dihydrochromeno[3,4-e][1,3]oxazine-2,5-diones in excellent yields. The salient features of this protocol are: short reaction times, high yields and absence of any hazardous organic solvent. Consequently, this procedure could be classified as green chemistry.

A clean, simple and efficient synthesis of trans-[3-(aryl)-2,3-dihydrofuro[3,2-h] quinolin-2-yl]-(4-chlorophenyl)methanones

2017 ◽  
Vol 41 (7) ◽  
pp. 380-383
Author(s):  
Maryam Salari ◽  
Alireza Hassanabadi ◽  
Mohammad H. Mosslemin
Keyword(s):  
Reaction Time ◽  
Green Chemistry ◽  
Aromatic Aldehyde ◽  
Efficient Method ◽  
Efficient Synthesis ◽  
Reaction Conditions ◽  
Short Reaction Time ◽  
High Yields

We report a green and efficient method for the synthesis of trans-[3-(aryl)-2,3-dihydrofuro[3,2- h]quinolin-2-yl]-(4-chlorophenyl) methanones from the condensation of 2-[2-(4-chlorophenyl)-2-oxoethyl)]isoquinolinium bromide with 8-hydroxyquinoline and an aromatic aldehyde in the presence of catalytic amounts of choline hydroxide in water at reflux conditions. This new protocol employing choline hydroxide, which is a green and inexpensive catalyst, offers advantages such as mild reaction conditions, short reaction time, high yields and does not involve any hazardous solvent. Therefore, this procedure can be classified as green chemistry.

Synthesis of a series of novel 2,3-dihydrofuranonaphthoquinone derivatives

2017 ◽  
Vol 41 (8) ◽  
pp. 448-451 ◽  
Author(s):  
Maryam Salari ◽  
Mohammad H. Mosslemin ◽  
Alireza Hassanabadi
Keyword(s):  
Reaction Time ◽  
Green Chemistry ◽  
Organic Solvent ◽  
Aromatic Aldehyde ◽  
Efficient Synthesis ◽  
One Pot ◽  
Short Reaction Time ◽  
Highly Efficient ◽  
One Pot Condensation ◽  
High Yields

A green and highly efficient synthesis of 12 novel trans-2-(4-chlorobenzoyl)-3-aryl-2,3-dihydronaphtho[2,3- b]furan-4,9-diones has been achieved via a three-component, one-pot condensation of 2-[2-(4-chlorophenyl)-2-oxoethyl)]isoquinolinium bromide with 2-hydroxy-1,4-naphthoquinone and an aromatic aldehyde in the presence of catalytic amounts of choline hydroxide in water under reflux conditions. The advantages of this method are a short reaction time, high yields and the avoidance of any hazardous organic solvent. Therefore, this procedure can be classified as green chemistry.

scholarly journals An Efficient Synthesis of 4-Aminomethyl-1-(2-Phenylethyl)-Piperidin-4-ol: A Key Intermediate in Fenspiride HCl Synthesis

2021 ◽  
pp. 139-146
Author(s):  
Prasad Panchabhai ◽  
Neelakandan Kaliaperumal ◽  
Gopalakrishnan Mannathusamy ◽  
Anbuselvan Chinnadurai
Keyword(s):  
Green Chemistry ◽  
Hazardous Waste ◽  
Building Block ◽  
Manufacturing Process ◽  
Good Yield ◽  
Aqueous Ammonia ◽  
Scale Production ◽  
Efficient Synthesis ◽  
Environment Friendly ◽  
Bulk Scale

The article confers a scalable manufacturing process of Fenspiride HCl. 4-aminomethyl-1-(2-phenylethyl)-piperidin-4-ol is the main building block in Fenspiride HCl synthesis. The reported reagents for 4-aminomethyl-1-(2-phenylethyl)-piperidin-4-ol synthesis are costly, explosive, highly toxic, produce hazardous waste, and also need to be handled with most care. The paper introduces aqueous ammonia as an alternate reagent in Fenspiride HCl and used in 4-aminomethyl-1-(2-phenylethyl)-piperidin-4-ol synthesis. The new green chemistry aspect makes the process environment-friendly and cheaper. It also eliminates toxic, sensitive, and hazardous reagents and makes the process safe on uncomplicated on bulk scale production. The high pure Fenspiride HCl is obtained by following this process and meets the ICH limits with good yield.

scholarly journals An efficient synthesis and spectroscopic characterization of Schiff bases containing 9,10-anthracenedione moiety

2013 ◽  
Vol 78 (4) ◽  
pp. 477-482
Author(s):  
Ghulam Fareed ◽  
Ali Versiani ◽  
Nighat Afza ◽  
Nazia Fareed ◽  
Irfan Ali ◽  
...  
Keyword(s):  
Green Chemistry ◽  
Schiff Bases ◽  
1H Nmr ◽  
13C Nmr ◽  
Room Temperature ◽  
Spectroscopic Characterization ◽  
Efficient Synthesis ◽  
Tungstosilicic Acid ◽  
Solvent Free Conditions

A new method has been developed for the synthesis of novel Schiff bases containg anthraquinone moiety using dodeca-Tungstosilicic acid/P2O5 under solvent free conditions at room temperature. The reaction was completed in 1-3 minutes with excellent yields. This method was found to be more efficient, easy and hazardous free for the synthesis of azomethines. The development of these type of methadologies in synthetic chemistry may contribute to green chemistry. The structures of synthesized novel Schiff bases was elucidated using 1H-NMR, 13C-NMR, LCMS, FTIR and CHN analysis.

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