scholarly journals ECG is an inefficient screening-tool for left ventricular hypertrophy in normotensive African children population

PeerJ ◽  
2016 ◽  
Vol 4 ◽  
pp. e2439 ◽  
Author(s):  
Giuseppe Di Gioia ◽  
Antonio Creta ◽  
Cosimo Marco Campanale ◽  
Mario Fittipaldi ◽  
Riccardo Giorgino ◽  
...  
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Standard Technique ◽  
Left Ventricular ◽  
Poor Correlation ◽  
Pediatric Hypertension ◽  
Left Ventricle Mass ◽  
African Children ◽  
Study Population ◽  
The Relationship

BackgroundLeft ventricular hypertrophy (LVH) is a marker of pediatric hypertension and predicts development of cardiovascular events. Electrocardiography (ECG) screening is used in pediatrics to detect LVH thanks to major accessibility, reproducibility and easy to use compared to transthoracic echocardiography (TTE), that remains the standard technique. Several diseases were previously investigated, but no data exists regarding our study population. The aim of our study was to evaluate the relationship between electrocardiographic and echocardiographic criteria of LVH in normotensive African children.MethodsWe studied 313 children (mean age 7,8 ± 3 yo), in north-Madagascar. They underwent ECG and TTE. Sokolow-Lyon index was calculated to identify ECG-LVH (>35 mm). Left ventricle mass (LVM) with TTE was calculated and indexed by height2.7(LVMI2.7) and weight (LVMIw). We report the prevalence of TTE-LVH using three methods: (1) calculating percentiles age- and sex- specific with values >95th percentile identifying LVH; (2) LVMI2.7>51 g/m2.7; (3) LVMIw>3.4 g/weight.Results40 (13%) children showed LVMI values >95th percentile, 24 children (8%) an LVMI2.7>51 g/m2.7while 19 children (6%) an LVMIw>3.4 g/kg. LVH-ECG by Sokolow-Lyon index was present in five, three and three children respectively, with poor values of sensitivity (ranging from 13 to 16%), positive predictive value (from 11 to 18%) and high values of specificity (up to 92%). The effects of anthropometrics parameters on Sokolow-Lyon were analyzed and showed poor correlation.ConclusionECG is a poor screening test for detecting LVH in children. In clinical practice, TTE remains the only tool to be used to exclude LVH.

Abstract P175: Can Pediatric Hypertension Criteria be Simplified? A Prediction Analysis of Subclinical Cardiovascular Outcomes From the Bogalusa Heart Study

Circulation ◽  
2017 ◽  
Vol 135 (suppl_1) ◽  
Author(s):  
Bo Xi ◽  
Tao Zhang ◽  
Shengxu Li ◽  
Wei Shen ◽  
Emily Harville ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Characteristic Curve ◽  
Later Life ◽  
Left Ventricular ◽  
Pediatric Hypertension ◽  
Bogalusa Heart Study ◽  
Heart Study ◽  
Subclinical Cardiovascular Disease

Background: Pre-hypertension and hypertension in childhood are defined by sex-, age- and height-specific 90th (or ≥120/80 mmHg) and 95th percentiles of blood pressure (BP), respectively, by the 2004 Fourth Report. However, these cut-offs are complex and cumbersome for use. This study assessed the performance of a simplified BP definition to predict adult hypertension and subclinical cardiovascular disease. Methods: The longitudinal cohort consisted of 1,225 adults (530 males, aged 26.3–47.7 years) from the Bogalusa Heart Study, with 27.1 years follow-up since childhood. We used 110/70 and 120/80 mmHg for children (age 6-11 years), and 120/80 and 130/85 mmHg for adolescents (age 12-17 years) as the simplified definitions of childhood pre-hypertension and hypertension, respectively, to compare with the complex definitions. Adult carotid intima-media thickness (CIMT), pulse wave velocity (PWV), and left ventricular mass were measured using digital ultrasound instruments. High CIMT was defined as being above the age-, gender- and race-specific 80th percentile, high PWV as being above the age-, gender-, race- and heart rate-specific 80th percentile and left ventricular hypertrophy as >46.7 g/m 2.7 in women and >49.2 g/m 2.7 in men. Results: Compared to normal BP, childhood hypertensives diagnosed by the simplified definition (4.1%, 50/1,225) and the complex definition (4.8%, 59/1,225) were both at higher risk of adult hypertension with hazard ratio=3.1 (95% confidence interval=1.8-5.3) by the simplified definition and 3.2 (2.0-5.0) by the complex definition, high PWV with 3.5 (1.7-7.1) and 2.2 (1.2-4.1), high CIMT with 3.1 (1.7-5.6) and 2.0 (1.2-3.6), and left ventricular hypertrophy with 3.4 (1.7-6.8) and 3.0 (1.6-5.6). The prediction using the two childhood BP definitions for adult hypertension and subclinical cardiovascular disease was also assessed by reclassification or receiver operating characteristic curve analyses. Conclusions: The simplified childhood BP definition predicts the risk of adult hypertension and subclinical cardiovascular disease equally as the complex definition does. The simplified pediatric BP cut-offs could be easier to use for screening children at high risk and for targeting early life interventions to reduce the risk of developing cardiovascular disease in later life.

A Cross-Sectional Study on the Relationship between Depression and Left Ventricular Hypertrophy

1998 ◽  
Vol 27 (6) ◽  
pp. 787-791 ◽  
Author(s):  
Yousuke Takemura ◽  
Shogo Kikuchi ◽  
Hirofumi Takagi ◽  
Yutaka Inaba ◽  
Katsuya Nakagawa
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Cross Sectional Study ◽  
Left Ventricular ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Relationship

The relationship of electrocardiographic left ventricular hypertrophy to decreased serum potassium

2012 ◽  
Vol 21 (3) ◽  
pp. 146-152 ◽  
Author(s):  
Peter M. Okin ◽  
Sverre E. Kjeldsen ◽  
Lars H. Lindholm ◽  
Björn Dahlöf ◽  
Richard B. Devereux
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Serum Potassium ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Relationship Of ◽  
The Relationship

scholarly journals Aldosterone synthase gene polymorphism in patients with hypertension combined ischemic heart disease with in various left ventricular mass

2014 ◽  
Vol 11 (1) ◽  
pp. 16-20
Author(s):  
D A Yahontov ◽  
D A Derisheva ◽  
L F Gulyaeva
Keyword(s):  
Coronary Artery Disease ◽  
Heart Disease ◽  
Left Ventricular Hypertrophy ◽  
Left Ventricular Mass ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Aldosterone Synthase ◽  
Ventricular Mass ◽  
Artery Disease ◽  
The Relationship

Study purpose - assessment of the relationship of levels of aldosterone and natriuretic peptide plasma aldosterone synthase gene polymorphism variants in patients with coronary heart disease (CHD) in combination with arterial hypertension (AH) at different left ventricular mass.Materials and methods. The study involved 63 male with hypertension and CHD; there were 32 men with signs of left ventricular hypertrophy (LVH) and 31 men with coronary artery disease with hypertension with a normal index of left ventricular mass. Evaluated the concentrations of aldosterone and plasma natriuretic peptide (NUP) in the relationship with characteristic of aldosterone synthase gene polymorphism.Results. It is established that the genotype CYP11В2 T/С of is associated with increased levels of aldosterone and signs of left ventricular hypertrophy. The level of LVC in the signs of LVH group was 2,1 fold higher than in patients without LVH. For patients with evidence of left ventricular hypertrophy is characterized by: the genotype of CYP11В2 T/C (62,5% of cases), the identification of the T allele (1,3 times more likely than patients without evidence of LVH) and more rarely than with normal index of left ventricular mass occurs variant CYP11В2 T/Т and more rarely prevalent allele C. Conclusion. In patients with coronary artery disease and hypertension, it is reasonable to implement in practice population genetic analysis to assess the probability the formation of left ventricular hypertrophy in the early stages of the disease.

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