scholarly journals Myocardial Performance Index Among Patients of Sickle Cell Disorder in Rural Teaching Hospital: A Case-Control Study

Cureus ◽  
2021 ◽  
Author(s):  
Anuj Chaturvedi ◽  
Sunil Kumar ◽  
Sourya Acharya ◽  
Shilpa A Gaidhane ◽  
Anil Wanjari ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Teaching Hospital ◽  
Performance Index ◽  
Case Control Study ◽  
Case Control ◽  
Myocardial Performance Index ◽  
Myocardial Performance ◽  
Rural Teaching ◽  
Cell Disorder ◽  
Control Study

Use of the Myocardial Performance Index in Decreased Fetal Movement Assessment: A Case-Control Study

2017 ◽  
Vol 43 (3) ◽  
pp. 208-217 ◽  
Author(s):  
Daphne Ho ◽  
Jingjing Wang ◽  
Yvette Homann ◽  
Jennifer Alphonse ◽  
Geraldene Beirne ◽  
...  
Keyword(s):  
Performance Index ◽  
Case Control Study ◽  
Case Control ◽  
Fetal Movement ◽  
Myocardial Performance Index ◽  
Myocardial Performance ◽  
Movement Assessment ◽  
Control Study

scholarly journals Risk of latent tuberculosis infection among diabetic patients in Azadi Teaching Hospital, Duhok province: a case control study

2018 ◽  
Vol 4 (2) ◽  
pp. 227-232 ◽  
Author(s):  
Muayad A Merza ◽  
Abdul Aziz Sulaiman Savo ◽  
Muhammad Jaafer
Keyword(s):  
Diabetes Mellitus ◽  
Teaching Hospital ◽  
Case Control Study ◽  
Case Control ◽  
Diabetic Group ◽  
Control Group ◽  
Diabetic Patients ◽  
Duration Of Diabetes ◽  
Previous Hospitalization ◽  
Control Study

Diabetes can be linked with impaired host immunity that subsequently increases the rate of various infections including tuberculosis (TB), particularly in developing countries where TB is endemic. The objectives of this case control study were to determine the prevalence and the risk of LTBI among diabetic patients. It is a prospective case control study conducted in Azadi Teaching Hospital from September 2017 until May 2018. The diabetic patients included in this study were randomly selected. The diagnosis of diabetes mellitus (DM) was made according to the American Diabetes Association (ADA). Diabetes mellitus patients and the control participants were offered a voluntary tuberculin skin test (TST). The TST ≥10 mm was considered positive. The results were analyzed by entering the data in SPSS (statistical package for the social sciences, version 16; SPSS Inc., Chicago, Illinois, USA). Two hundred DM patients and 208 control individuals participated in this study. Collectively, 28 patients had positive TST results. Based on the sputum smear microscopy and CXR, none of these patients showed active TB disease. The differences between the DM patients and the control group had no statistical significance apart from previous hospitalization. The prevalence of LTBI was 23.53% in the diabetic group, whereas, it was 9.62% in the control group. The frequency of LTBI in diabetic patients was significantly higher than the control group. When the diabetic group was compared with the control group in terms of diabetic control and the duration of diabetes disease, there was a statistically significant association of diabetes duration ≥ 10 years and TST positivity. In conclusion, the previous hospitalization was a significant risk factor for diabetic patients to acquire TB bacilli. Latent TB infection was more common in diabetics than non diabetics and there was an increased likelihood of having LTBI with the duration of diabetes ≥ 10 years. To avoid the threatening of TB control program, prophylactic treatment of LTBI in diabetic patients is paramount.Asian J. Med. Biol. Res. June 2018, 4(2): 227-232

Morbidity and mortality in sickle cell pregnancies in Lagos, Nigeria: A case control study

2009 ◽  
Vol 29 (2) ◽  
pp. 104-106 ◽  
Author(s):  
B. B. Afolabi ◽  
N. C. Iwuala ◽  
I. C. Iwuala ◽  
O. K. Ogedengbe
Keyword(s):  
Sickle Cell ◽  
Case Control Study ◽  
Case Control ◽  
Morbidity And Mortality ◽  
Control Study

scholarly journals Selected Candidate Genes and Obesity Among Ghanaian Adults: A Case-control Study at the Korle-Bu Teaching Hospital (Dietherapy Unit) Accra (P15-014-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Amos Gyamfi ◽  
Charles Brown ◽  
Samuel Antwi-Baffour
Keyword(s):  
Teaching Hospital ◽  
Leptin Receptor ◽  
Case Control Study ◽  
Case Control ◽  
Peroxisome Proliferator ◽  
Nucleotide Polymorphisms ◽  
Funding Sources ◽  
Validated Questionnaire ◽  
Significant Difference ◽  
Control Study

Abstract Objectives The aim of the study was to investigate the relationship between single nucleotide polymorphisms (SNPs) of selected genes (β3-adrenergic receptors-ADRB3, Leptin receptor-LEPR, Peroxisome proliferator activator receptor γ-PPARG) and obesity among Ghanaian adults. Methods This was a case-control study comprising 24 cases of newly diagnosed obese; BMI ≥30 kg/m2, at the Dietherapy Unit of the Korle-Bu Teaching Hospital (KBTH), and 32 controls of non-obese staff and clinical students at KBTH. A validated questionnaire was used for demographic, dietary and anthropometric data. Dietary intake was assessed using a food frequency questionnaire, and DNA extracted from mouth rinse water samples. SNPs in the ADRB3, LEPR and PPARG genes were determined by polymerase chain reaction restriction fragment length polymorphism (PCR –RFLP). Results There were statistically significant differences in BMI, WHR and MUAC measurements between cases and controls (all p s˂ 0.0001). There was no statistically significant difference (P = 0.3032) between the mean energy intakes of both cases and controls. DNA fragments for the PPARG gene was amplified in 55 respondents. No relationship was observed between PPARG (Pro12Pro) SNP and BMI, MUAC and WHR among participants. Amplification was successful in 19 cases and 24 controls for ADRB3 (Trp64Trp & Trp64Arg). No significant difference (all ps > 0.05) emerged for the ADRB3 SNPs frequencies between the cases and the controls for BMI, MUAC and WHR. LEPR amplification was successful in 15 cases and 14 controls. Amplicons of six cases, all in the OBClass 1 to OBClass 3 range, indicated the presence of the Gln223Arg SNP after RFLP. A significant difference (all ps < 0.05) emerged for LEPR (Gln223Arg) SNP frequencies between the cases and the controls for BMI, MUAC and WHR. Conclusions There were no observed relationships among ADRB3, PPARG SNPs and BMI, MUAC and WHR. LEPR (Gln223Arg) SNP was statistically associated with BMI, MUAC and WHR. Funding Sources 1. College of Health Sciences, University of Ghana Research Grant for MSc/MPhil Thesis/Dissertation. 2. Self funding.

Sleep In Patients with Sickle Cell Anemia and Priapism. A Case-Control Study

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 1644-1644
Author(s):  
Marina Roizenblatt ◽  
Frederico Pollack-Filho ◽  
Joao R Sato ◽  
Perla Vicari ◽  
Francisca Veloso ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Rem Sleep ◽  
Case Control Study ◽  
Conflicts Of Interest ◽  
Case Control ◽  
Apnea Hypopnea Index ◽  
Penile Tumescence ◽  
Control Study ◽  
Overnight Polysomnography

Abstract Abstract 1644 Background. Priapism has been described as a sickle cell anemia (SCA) manifestation that occurs frequently during sleep. Given that hypoxemia has been implicated in the pathogenesis of SCA complications, we conducted this case control study of overnight polysomnography and penile tumescence recording in SCA adults with and without priapism, with the hypothesis that SCA patients with priapism might exhibit apnea and oxyhemoglobin desaturation during sleep. Objectives. The primary endpoint was to determine the relation between increase in penile tumescence (of 20%) and respiratory sleep events (apnea, hypopnea and desaturation >3%). Further sleep event associations with penile tumescence variation and other differences between groups regarding sleep pattern were assessed as secondary endpoints. Methods. Seventeen SCA adults with priapism and 14 without history during the previous 12 month period were submitted to clinical interview and overnight polysomnography (Somnologica, Embla™), concomitantly performed with penile tumescence recording (Rigiscan Plus, Timm Medical™). Results and Discussion. There was no statistical difference between groups (t test, Chi2 or Fisher) in terms of age (mean ± s.d., 31.2 ± 14.0 vs. 27.8 ± 7.0 yrs, p=0.39), body mass index (20.9 ± 3.7 vs. 21.4 ± 2.3 kg/m2, p=0.66), use of hydroxyurea (41 vs. 43%, p=1.00), levels of ferritin (257.2 ± 291.8 vs. 429.1 ± 410.8 mg/L, p=0.27), hemoglobin (10.0 ± 1.9 vs. 9.4 ± 1.7 mg/dL, p=0.45) and hematocrit (27.4 ± 8.3 vs. 27.0 ± 5.3 %, p=0.89). No difference was also observed in sleep architecture and number of events of increase in penile tumescence, both in non rapid eye movement (non REM) and REM sleep (21.9 ± 6.8 vs. 18.2 ± 7.6, p=0.17 and 7.5 ± 3.3 vs. 8.3 ± 5.0, p=0.59, respectively). Coincidence of these events with apnea-hypopnea, desaturation and periodic leg movement (PLM) events in non REM sleep was greater in SCA patients with priapism than in those without it (16.9 ± 11.1 vs. 7.9 ± 7.1, respectively, p=0.01). PLM index was increased in both groups, particularly in SCA patients with priapism (16.1 ± 16.2 vs. 5.7 ± 5.4 /h, p= 0.03) and associated with restless leg syndrome (88.2 vs. 50.0 %, respectively, p=0.02). Desaturation index was also higher in priapism group, in comparison to non-priapism (12.7 ± 8.8 vs. 7.6 ± 3.6 /h, respectively, p=0.05), as well as apnea hypopnea index (12.2 ± 11.0 vs. 5.5 ± 4.5 /h, respectively, p=0.04). Conclusion. Compared to the group without priapism, SCA patients with priapism presented increase in apnea hypopnea index, PLM indexes during sleep and also association of increase in penile tumescence with respiratory events and PLM during non REM sleep. Our findings reinforce the literature data which highlights the link between disordered sleep and vaso-occlusive events in SCA. Moreover, the high frequency of PLM in SCA patients could be related to lower hepcidin levels recently observed in both SCA and restless legs syndrome. FAPESP CEPID 98/14303-3 and AFIP. Disclosures: No relevant conflicts of interest to declare.

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