scholarly journals Unique Case of Mediastinal Teratoma with Unusual components

Author(s):  
Anand Deodhar ◽  
Dinesh Kulkarni

Mature teratoma is a benign, slow growing tumour. It usually affect adults in 20-40 years of age. Teratomas with mature pancreatic tissue are extremely rare. There are only a few cases of teratoma containing mature pancreatic tissue that have been reported in literature. Authors report a case of a 25-year-old male having a large solid cystic anterior mediastinal mass, which on excision, histologically revealed large areas of mature pancreatic tissue along with squamous epithelium with sebaceous glands and keratin, pseudostratified columnar ciliated epithelium, mucin secreting glands, cartilage, pigment and other germ cell derived mature elements. This is a unique case with unusual microscopic findings in the form of predominant pancreatic and also brain tissue along with other elements.

CHEST Journal ◽  
2018 ◽  
Vol 154 (4) ◽  
pp. 609A
Author(s):  
MANASA REDDY ◽  
RANIA FARHAT ◽  
ARMIN KRVAVAC ◽  
SETU PATOLIA

2019 ◽  
Vol 08 (01) ◽  
pp. e24-e26 ◽  
Author(s):  
Christopher James Kennedy ◽  
David James William Paton

Background Thymic hyperplasia is a recognized complication of Graves' disease that can present radiologically as an anterior mediastinal mass. Case Description We present a unique case of massive thymic hyperplasia occurring in a 24-year-old female without a known history of thyroid or other systemic disease in whom Graves' disease first manifested intraoperatively during thymectomy for presumed neoplasia. Conclusion We suggest that the work-up of all anterior mediastinal masses should include a comprehensive search for medical causes of reversible thymic enlargement.


2020 ◽  
Vol 7 (11) ◽  
pp. C169-171
Author(s):  
Sreeja Raju ◽  
Divya S ◽  
M C Savithri ◽  
Ajaykumar KK ◽  
Gayathri G Nair

Thymolipomas are rare, slow-growing, benign anterior mediastinal neoplasms which are very often detected incidentally. Here we present a case of a 47 year old female who presented with chest discomfort and radiology revealed an anterior mediastinal mass. Total thymectomy was done and histopathology showed features consistent with thymolipoma. Very few cases of thymolipomas have been reported in Indian and world literature.


Rare Tumors ◽  
2020 ◽  
Vol 12 ◽  
pp. 203636132097921
Author(s):  
Mohammad Hossein Anbardar ◽  
Fatemeh Amirmoezi ◽  
Armin Amirian

Thymoangiolipoma is a rare, slow-growing, benign thymic neoplasm that arises from the anterior mediastinum. A 61-year-old man with the chief complaint of right eye ptosis and high serum acetylcholine receptor antibody level is presented here. The spiral computed tomography of the chest revealed a hypodense mass in the anterior mediastinum. Microscopic examination showed admixture of adipose tissue, thymic tissue and blood vessels with the diagnosis of thymoangiolipoma. Thymoangiolipoma is a rare histologic variant of thymolipoma which can be associated with myasthenia gravis and must be considered as a differential diagnosis in anterior mediastinal mass with fat density in radiologic evaluation.


Author(s):  
Tanisha Singh ◽  
Gramani Arumugam Vasugi ◽  
Swaminathan Rajendiran ◽  
. Manickavasagam ◽  
. Shanmuganathan

Collision tumours are relatively rare entities and are thus, not well recognised. Collision tumour can be defined as two coexisting but histologically different malignancies involving the same organ or adjacent organ with an equivocal intermediate transitional zone between them. Collision tumours of the lung and oesophagus are very rare. Such cases are diagnosed by Computerised Tomogram (CT) Scan or Chest X-Ray for complaint of dysphagia. Definitive diagnosis is made by tissue biopsy. Here, a 66-year-old male is admitted for evaluation of an anterior mediastinal mass. Radiology revealed an anterior mediastinal mass extending in to the left hilar region and upper lobe of right lung anteriorly and in to the lower end of oesophagus posteriorly. Biopsy was performed. Microscopically, transbronchial biopsy revealed a cellular lesion, composed of round-to-oval cells with streaming nucleus, positive for Immunohistochemistry (IHC) markers, CD-56 and Synaptophysin pertaining to a diagnosis of small cell carcinoma. Biopsy of the oesophageal growth shows nest of dysplastic squamous epithelium which infiltrates into underlying muscularis propria showing features of a squamous cell carcinoma. Multiple fragments of squamous epithelium are also seen with necrotic tissue in vicinity and acute inflammatory exudate. Few cells show multinucleation, molding and margination of chromatin, showing the characteristic morphological features of Herpes oesophagitis. The patient was administered platinum-based Chemotherpy.


This report describes the case of a 39-year-old man with a mediastinal teratoma. For seven years the patient had been suffering a dyspnea on exertion. In the last few weeks, the dyspnea increased and new symptoms appeared such as dry cough, chest pain and palpitations. Computed tomography revealed a medium-sized tumor that was markedly compressing the superior vena cava and the right atrium. Surgery was performed, and a benign mature teratoma was diagnosed. Mature mediastinal teratomas are benign tumors, but they can be adherent to collateral structures in the chest leading to life threatening complications.


2018 ◽  
pp. bcr-2018-227022 ◽  
Author(s):  
Bruce R Brenn ◽  
Srijaya K Reddy ◽  
Kyle J Van Arendonk ◽  
Walter M Morgan

Anterior mediastinal masses present a significant challenge in the perioperative period. Standard anaesthetic induction and airway management are often not feasible due to the risk of complete respiratory and/or cardiovascular collapse. Invasive manoeuvres, such as extracorporeal membrane oxygenation, cardiac bypass, or tracheal or bronchial stenting, are sometimes not applicable due to significant anatomic aberration. We present a case of anterior mediastinal mass in a 5-month-old infant where typical management techniques in the treatment algorithm were not possible.


2015 ◽  
Vol 2015 ◽  
pp. 1-5
Author(s):  
Peter A. Andrawes ◽  
Masood A. Shariff ◽  
Qing Chang ◽  
Fanyi Kong ◽  
Frank M. Rosell

Neuroendocrine tumors that arise in an extragonadal teratoma are extremely rare. Somatic-type malignancy, defined as any sarcoma, carcinoma, leukemia, or lymphoma developing in a germ cell tumor, occurs in approximately 2% of all germ cell tumors. Our case represents a mediastinal mass that was incidentally found in a patient with syncope. Surgical resection confirmed mature teratoma with neuroendocrine features.


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