scholarly journals ANTICANCER ACTIVITY OF UPAVISHA SNUHI: A COMPREHENSIVE UPDATE

2020 ◽  
Vol 9 (6) ◽  
pp. 162-166
Author(s):  
Asolkar Geeta Govindrao ◽  
Nikam Ashwin Vithalrao ◽  
Pawade Uday Venkatrao ◽  
Anjankar Meghsham Pramodrao
Keyword(s):  
Anticancer Activity ◽  
20Th Century ◽  
21St Century ◽  
Anticancer Agent ◽  
In Vivo Studies ◽  
Classical Text ◽  
Ancient Science

Cancer is one of the dreaded diseases of 20th century responsible for causing most fatalities and spreading further with increasing incidence in 21st century. Ayurveda an ancient science provides many useful remedies for these types of advanced diseases. Upavishas narrated in Agadtantra contribute for many fruitful therapeutic formulations. Snuhi (Euphorbia neriifolia Linn.) is one among these upavishas is knocking out as an effective Anticancer agent. Traditionally it is mainly used in Kushtha, Udara, Shotha, Pandu, Gulma, Dushivisha, Visha chikitsa. Various In Vitro & In Vivo studies has been conducted to evaluate the anticancer activity of Upavisha Snuhi (Euphorbia neriifolia Linn.) in the form of its extracts. In this study a special emphasis is on gathering details of Upavisha Snuhi from available classical text and assemble data related to the In Vivo and In Vitro Anticancer activity of Upavisha Snuhi.

Vitamin D as potential therapeutic anticancer agent

2018 ◽  
pp. 1-3
Keyword(s):  
Vitamin D ◽  
Anticancer Activity ◽  
Anticancer Agent ◽  
Antitumor Agents ◽  
Metastatic Potential ◽  
Anticancer Properties ◽  
Chemotherapy Agents

The role of vitamin D is implicated in carcinogenesis through numerous biological processes like induction of apoptosis, modulation of immune system inhibition of inflammation and cell proliferation and promotion of cell differentiation. Its use as additional adjuvant drug with cancer treatment may be novel combination for improved outcome of different cancers. Numerous preclinical, epidemiological and clinical studies support the role of vitamin D as an anticancer agent. Anticancer properties of vitamin D have been studied widely (both in vivo and in vitro) among various cancers and found to have promising results. There are considerable data that indicate synergistic potential of calcitriol and antitumor agents. Possible mechanisms for modulatory anticancer activity of vitamin D include its antiproliferative, prodifferentiating, and anti-angiogenic and apoptic properties. Calcitriol reduces invasiveness and metastatic potential of many cancer cells by inhibiting angiogenesis and regulating expression of the key molecules involved in invasion and metastasis. Anticancer activity of vitamin D is synergistic or additive with the antineoplastic actions of several drugs including cytotoxic chemotherapy agents like paclitaxel, docetaxel, platinum base compounds and mitoxantrone. Benefits of addition of vitamin D should be weighed against the risk of its toxicity.

scholarly journals ANTICANCER ACTIVITY OF UPAVISHA ARKA: AN OVERVIEW

2020 ◽  
Vol 9 (6) ◽  
pp. 175-181
Author(s):  
Chandekar Deepali Boudhadas ◽  
Pawade Uday Venkatrao ◽  
Nikam Ashwin Vithalrao ◽  
Anjankar Meghsham Pramodrao
Keyword(s):  
Anticancer Activity ◽  
Anticancer Drugs ◽  
Anticancer Drug ◽  
Cost Effective ◽  
In Vivo Studies ◽  
Calotropis Procera ◽  
Calotropis Gigantea ◽  
Natural Derivative

Cancer is one amongst the dreadful diseases of present century. The incidence of cancer is increasing worldwide. Every year about 8,00,000 new cancer patients get registered with the national cancer registry program in India. Ayurveda an ancient Indian medicine science describes many useful herbal drugs for such types of advanced diseases. Upavisha the plant poisons of low potency are mentioned in Agadtantra. Arka (Calotropis procera/ Calotropis gigantea) is one among these Upavisha is emerging as an effective anticancer drug. It shows various pharmacological activities such as Anticancer, Antimicrobial, Antiimplantation etc. Different parts of Arka are used to treat cancer. In current scenario number of synthetic anticancer drugs are used to treat cancer. These synthetic anticancer drugs are expensive and shows harmful adverse effects. Upavisha like Arka which is natural derivative may be cost effective & less harmful as Anticancer drug. Anticancer activity of Calotropis procera/Calotropis gigantea is reported in scientific journals. This review summarizes various In Vitro and In Vivo studies of anticancer activity of Upavisha Arka.

In vitro and in vivo studies of a novel potential anticancer agent of isochaihulactone on human lung cancer A549 cells

2006 ◽  
Vol 72 (3) ◽  
pp. 308-319 ◽  
Author(s):  
Yi-Lin Chen ◽  
Shinn-Zong Lin ◽  
Jang-Yang Chang ◽  
Yeung-Leung Cheng ◽  
Nu-Man Tsai ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Anticancer Agent ◽  
Human Lung ◽  
A549 Cells ◽  
In Vivo Studies ◽  
Human Lung Cancer

A novel valproic acid prodrug as an anticancer agent that enhances doxorubicin anticancer activity and protects normal cells against its toxicity in vitro and in vivo

2014 ◽  
Vol 88 (2) ◽  
pp. 158-168 ◽  
Author(s):  
Nataly Tarasenko ◽  
Suzanne M. Cutts ◽  
Don R. Phillips ◽  
Gili Berkovitch-Luria ◽  
Elinor Bardugo-Nissim ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Anticancer Activity ◽  
Anticancer Agent ◽  
Normal Cells ◽  
Toxicity In Vitro

Cranberry: A Promising Natural Source of Potential Nutraceuticals with Anticancer Activity

2019 ◽  
Vol 19 (14) ◽  
pp. 1672-1686
Author(s):  
Maria Mantzorou ◽  
Apostolos Zarros ◽  
Georgios Vasios ◽  
Stamatios Theocharis ◽  
Eleni Pavlidou ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Anticancer Activity ◽  
Experimental Studies ◽  
In Vivo Studies ◽  
Chemopreventive Agents ◽  
Anticancer Properties ◽  
Pubmed Database ◽  
Prevention And Treatment

Studies have shown that cranberry and its components may exert anticancer properties. The present study aims to critically summarise the existing experimental studies evaluating the potential effects of cranberry on cancer prevention and treatment. PubMed database was searched to identify relevant studies. Current in vitro studies have indicated that cranberry and/or its components may act as chemopreventive agents, diminishing the risk for cancer by inhibiting cells oxidation and inflammatory-related processes, while they may also exert chemotherapeutic effects by inhibiting cell proliferation and angiogenesis, inducing cell apoptosis and attenuating the ability of tumour cells to invade and metastasis. Limited in vivo studies have further documented potential anticancer activity. Cranberry could be considered as a conglomeration of potential effective anticancer druglike compounds.

scholarly journals Investigation of the in vitro Anticancer Activity of Sorbus aria Extract on Prostate Cancer

2020 ◽  
Vol 3 (1) ◽  
pp. 228-235
Author(s):  
Tilbe Özar ◽  
M. Fatih Özalp ◽  
Erdal Eroğlu
Keyword(s):  
Prostate Cancer ◽  
Anticancer Activity ◽  
Anticancer Agents ◽  
Ethanol Extract ◽  
Central Anatolia ◽  
In Vivo Studies ◽  
Total Phenol Content ◽  
Sorbus Aria

Cancer is one of the common diseases observed in our country and worldwide with a high mortality rate. Although cancer has been treated with different applications such as chemotherapy, radiotherapy and surgical operation, the exact remedy of this disease has still not been found, yet. The fact that current treatment methods have severe side effects on patients has increased the interest in natural anticancer agents that are accepted easily and considered as safer by society. The aim of this study is to investigate the anticancer activity of whitebeam (Sorbus aria) that grows in the Central Anatolia Region in Turkey, extract on PC-3 human prostate cancer cells in vitro. The anticancer activity of the ethanol extract obtained from whitebeam fruits evaluated using MTT cell proliferation assay. Also, Folin-Ciocalteu assay and CUPRAC method were performed to determine total phenol content and antioxidant capacity of whitebeam fruits, respectively. Whitebeam fruit extract showed strong anticancer activity on prostate cancer in vitro. The obtained ethanol extract is found to be a promising natural anticancer agent in vitro, and our findings need to be verified with in vivo studies and clinical trials.

In vitro and in vivo studies of new cationic Zn(II)‐benzonaphthoporphyrazines as photosensitizers for PDT

2001 ◽  
Vol 5 (8) ◽  
pp. 645-651
Author(s):  
M. Peeva ◽  
M. Shopova ◽  
U. Michelsen ◽  
D. Wöhrle ◽  
G. Petrov ◽  
...  
Keyword(s):  
In Vivo Studies
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