Clinical Profile and Outcomes of Acute Kidney Injury Patients in an Intensive Care Unit in India: A Retrospective Study

Background: Acute kidney injury (AKI) is an important condition in hospitalized patients, associated with adverse short- and long-term outcomes. Objective of this study was to determine the clinical profile of acute kidney injury in pediatric ICU (Basaveshwar Teaching and General Hospital, Sangameshwar Hospital, Kalaburagi).Methods: This study was conducted in all patients within the age group of 1 month to 18 years admitted in the PICU (pediatric intensive care unit) at Basaveshwar teaching and General hospital and Sangameshwar hospital attached to Mahadevappa Rampure medical college during a period from December 2015 to May 2017.Results: Incidence of AKI was 6.9% in pediatric intensive care unit. The median age of boys and girls were 4.56±3.84 and 4.49±4.01 respectively. Hypotension and need for ventilation were significant risk factors for AKI (p<0.001). The median admission serum creatinine value in AKI patients was 2.91±2.48 mg/dL. In the present study, the median duration of PICU and Hospital stay was 9.98±7.27 in AKI group compared to7.41±5.62 days in non-AKI group (p<0.001).Conclusions: It was concluded that Incidence of AKI was 6.9% in pediatric intensive care unit. The mean and SD of age of boys and girls were 4.56±3.84 and 4.49±4.01 respectively. Hypotension and need for ventilation were significant risk factors for AKI.

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Clinical profile and outcomes of acute kidney injury patients in an intensive care unit in India

International Journal of Clinical Trials ◽

10.18203/2349-3259.ijct20204481 ◽

2020 ◽

Vol 7 (4) ◽

pp. 245

Author(s):

Vivek S. Narayan Pillai ◽

C. Joe Varghese ◽

Christopher C. Pais ◽

Vijay Gopal Rai ◽

Mahabala Chakrapani

Keyword(s):

Intensive Care Unit ◽

Acute Kidney Injury ◽

Intensive Care ◽

Mortality Rate ◽

Care Center ◽

Tertiary Care ◽

Kidney Injury ◽

Clinical Profile ◽

Treatment Modalities ◽

Presenting Symptoms

Background: The limited epidemiological and outcome data of acute kidney injury (AKI) is available in developing countries. The current single-center study determined the clinical profile of AKI by attempting to identify the presenting symptoms, etiologies, treatment modalities, and disease prognosis in patients admitted in intensive care unit at a tertiary care center in Mangalore, India.Methods: This retrospective study enrolled 70 AKI patients between October 2001 and October 2003, admitted at Wenlock district hospital, Mangalore, KMC hospital Attawar, Mangalore and KMC hospital, Jyothi circle, Mangalore, having a serum creatinine level greater than 1.4 mg/dl and blood urea greater than 53 mg/dl.Results: Amongst the enrolled patients, 45.7% of patients were 40-60 years old and 49 were males with no significant (p=0.412) gender difference. The most common presenting symptom was diminished micturition present in 47.1% of patients and the most common etiology of AKI was sepsis found in 27.1% of patients with the highest (17.1%) mortality. Amongst the patients who underwent conservative treatment (n=52) the mortality rate was 42.8%, while in those who underwent hemodialysis (n=18) the mortality rate was 4.2%. The overall survival rate in the study was 52.9%.Conclusions: The epidemiological data obtained in this study is similar to the previous studies in India with hemodialysis appearing to have better disease outcomes compared to conservative therapy.

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