scholarly journals Chemical Constituents from Wood of Zanthoxylum rigidum Hum. and Bonpl. Ex Willd (Rutaceae) and Antileishmanial Activities

2021 ◽  
pp. 14-20
Author(s):  
Carlos H. C. dos Santos ◽  
Mayara C. Sousa ◽  
Paulo T. de Sousa Jr. ◽  
Tereza A. N. Ribeiro ◽  
Marco J. Jacinto ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Inhibitory Activity ◽  
Chemical Constituents ◽  
Positive Control ◽  
Leishmania Braziliensis ◽  
Leishmania Chagasi ◽  
Ft Ir ◽  
Antileishmanial Activities

In this study was reported the structural elucidation by means of nuclear magnetic resonance (1D and 2D), FT-IR and mass spectrometry of lupeol (1), a mixture of the steroids campesterol (2), b-sitosterol (3) and stigmasterol (4), sesamin (5), trans-dimethylmatairesinol (6), trans-methylpluviatolide (7), quercetin (8), and d-mannitol (9) isolated from wood of Zanthoxylum rigidum. The lignans 5, 6 and 7 were tested for their ability to inhibit the proliferation of the promastigote forms of Leishmania braziliensis and Leishmania chagasi. Only sesamin (5) and trans-methylpluviatolide (7) showed moderate inhibitory activity with IC50 = 22.4 and 33.6, SI = 3.87 and 2.41 and CC50 = 86.9 and 81.2, for L. braziliensis and L. chagasi, respectively, compared to the positive control (amphotericin B).

scholarly journals Two New AChE Inhibitors Isolated from Li Folk Herb Heilaohu “Kadsura coccinea” Stems

Molecules ◽  
2019 ◽  
Vol 24 (19) ◽  
pp. 3628
Author(s):  
Sheng Zhuo Huang ◽  
Lin Ping Duan ◽  
Hao Wang ◽  
Wen Li Mei ◽  
Hao Fu Dai
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Spectroscopic Data ◽  
Positive Control ◽  
Ache Inhibitors ◽  
Activity Test ◽  
Ache Inhibitory Activity ◽  
Kadsura Coccinea ◽  
Ellman’S Method

Two new triterpenoids, named kadsuricoccins A and B, together with three known ones, were isolated from the Li folk herb Heilaohu, the stems of Kadsura coccinea (Lem.) A. C. Smith, which was used for food and as a healthy supplement. Their structures were elucidated by comprehensive analyses of mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopic data. To search healthy components, an acetylcholinesterase (AChE) inhibitory activity test by Ellman’s Method was conducted, kadsuricoccins A and B showed activity with the AChE inhibit index (AII) up to 68.96% ± 0.19% and 57.8% ± 0.11% at 94 nM (compared with positive control tacrine AII 79.80% ± 0.20%, 9.4 nM), respectively.

Identification of benzisoquinolinone derivatives with cytotoxicities from the leaves of Portulaca oleracea

2019 ◽  
Vol 74 (5-6) ◽  
pp. 139-144
Author(s):  
Rong-Rui Wei ◽  
Qin-Ge Ma ◽  
Guo-Yue Zhong ◽  
Ming Yang ◽  
Zhi-Pei Sang
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
A549 Cell ◽  
Positive Control ◽  
Portulaca Oleracea ◽  
Spectroscopic Methods ◽  
First Time ◽  
Mcf 7

Abstract Three new benzisoquinolinones (1–3), together with seven known benzisoquinolinone derivatives (4–10), were isolated from Portulaca oleracea for the first time. The structures of the isolated compounds (1–10) had been elucidated on the basis of extensive spectroscopic methods including ultraviolet, infrared, mass spectrometry, and nuclear magnetic resonance techniques and by comparison with data reported in the references. All isolated compounds were assayed for cytotoxicities against selected human lines in vitro by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide assay. Compounds 1, 2, 4, and 7 showed important cytotoxicities against HCT116, MCF-7, U87, and A549 cell lines with IC50 values in the range of 11.62–84.45 μM, which compared with positive control doxorubicin.

scholarly journals One New Terphenyl Glycoside From a Sponge-Derived Fungus Trichoderma reesei (HN-2016-018)

2020 ◽  
Vol 15 (2) ◽  
pp. 1934578X2090775
Author(s):  
Saif Ur Rehman ◽  
Jing-Shuai Wu ◽  
Lu-Jia Yang ◽  
Shi Ting ◽  
Chang-Lun Shao ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
High Resolution ◽  
Electrospray Ionization ◽  
Trichoderma Reesei ◽  
Electrospray Ionization Mass Spectrometry ◽  
Inhibitory Activity ◽  
Spectroscopic Analysis ◽  
Ionization Mass

One new terphenyl glycoside (1), gliocladinin D, together with 4 known compounds (2-5) were isolated from the sponge-derived fungus Trichoderma reesei (HN-2016-018). The structure of the new compound was elucidated by the comprehensive spectroscopic analysis, including 1-dimensional and 2-dimensional nuclear magnetic resonance, and high-resolution electrospray ionization mass spectrometry. Compound 3 exhibited moderate Topo I inhibitory activity.

The regioselective catalyst-free synthesis of bis-quinoxalines and bis-pyrido[2,3-b]pyrazines by double condensation of 1,4-phenylene-bis-glyoxal with 1,2-diamines

2018 ◽  
Vol 24 (4) ◽  
pp. 193-196 ◽  
Author(s):  
Mehdi Ahmadi Sabegh ◽  
Jabbar Khalafy
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
New Products ◽  
Proton Nuclear Magnetic Resonance ◽  
Efficient Synthesis ◽  
H Nmr ◽  
Ft Ir ◽  
C Nmr ◽  
Nuclear Magnetic

AbstractThe oxidation of 1,4-diacetylbenzene using several oxidizing agents gave 1,4-phenylene-bis-glyoxal in 61–85% yields. A convenient and efficient synthesis of bis-quinoxaline and bis-pyrido[2,3-b]pyrazine derivatives involves the double condensation of 1,2-diamines with 1,4-phenylene-bis-glyoxal in ethanol under reflux conditions. The structures of the new products were defined by proton nuclear magnetic resonance (1H NMR), carbon-13 nuclear magnetic resonance (13C NMR), Fourier-transform infrared spectroscopy (FT-IR) and mass spectrometry (MS).

scholarly journals Chemical constituents and antiviral study of Goniothalamus velutinus

2014 ◽  
Vol 6 (1) ◽  
Author(s):  
Fasihuddin Badruddin Ahmad ◽  
Nur Khairun Nisa Mohd Sallehuddin ◽  
Zaini Assim
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
Gas Chromatography ◽  
Measles Virus ◽  
Chemical Constituents ◽  
Positive Control ◽  
Gas Chromatography Mass Spectrometry ◽  
Spectroscopic Methods ◽  
Phytochemical Study ◽  
Weak Activity

Phytochemical study on the stem barks of Goniothalamus velutinus resulted in the isolation of three compounds identified as goniothalamin (1), pinocembrine (2) and naringenin (3). Their structures were elucidated using various spectroscopic methods especially Fourier Transform Infrared (FTIR), Nuclear Magnetic Resonance (NMR) and gas chromatography-mass spectrometry (GC-MS). Goniothalamin (1) has been isolated from several Goniothalamus spp. but no report on the isolation of (1) from Goniothalamus velutinus. Antiviral properties of (1) against Measles virus showed weak activity compared to positive control, ribavirin.

Methods to Determine Phytopharmaceuticals in Tobacco and Tobacco Products. 4th Report: A Procedure to Determine Vamidothion and its Metabolites/Methoden zur Bestimmung von Phytopharmaka in Tabak und Tabakerzeugnissen: IV. Mitteilung: Ein Bestimmungsverfahren fuer Vamidothion und seine Metaboliten

1977 ◽  
Vol 9 (2) ◽  
Author(s):  
A.N. Sagredos ◽  
R. Moser
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
Acetic Acid ◽  
Magnetic Resonance ◽  
Aluminium Oxide ◽  
Nuclear Magnetic Resonance Data ◽  
Gas Chromatograph ◽  
Tobacco Products ◽  
Magnetic Resonance Data ◽  
Resonance Data

AbstractBased on previous work (7) a method to simultaneously determine vamidothion [I], vamidothion-sulfoxide [II] and vamidothion sulfone [III] in tobacco has been developed. The compounds are extracted with water/acetone/acetic acid from the tobacco, cleansed over an aluminium oxide column and then determined on the gas chromatograph with the specific sulphur detector. Rates of recovery are 70 % - 92 %, the determination level is 0.1 ppm. Mass spectrometry and nuclear magnetic resonance data of vamidothion [I], vamidothion-sulfoxide [ II ] and vamidothion-sulfone [III] are given.

scholarly journals N,N-Bis(Hexyl α-d-Acetylmannosyl) Acrylamide

Molbank ◽  
10.3390/m1255 ◽  
2021 ◽  
Vol 2021 (3) ◽  
pp. M1255
Author(s):  
Atsushi Miyagawa ◽  
Shinya Ohno ◽  
Hatsuo Yamamura
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Nuclear Magnetic Resonance Spectroscopy ◽  
Side Reaction ◽  
Resonance Spectroscopy ◽  
Biological Functions ◽  
Unknown Compound ◽  
Acrylamide Monomer

Glycosyl monomers for the assembly of multivalent ligands are typically synthesized using carbohydrates with biological functions and polymerizable functional groups such as acrylamide or styrene introduced into the carbohydrate aglycon, and monomers polymerized using a radical initiator. Herein, we report the acryloylation of 6-aminohexyl α-mannoside and its conversion into the glycosyl monomer bearing an acrylamide group. The general acryloylation procedure afforded the desired N-hexyl acetylmannosyl acrylamide monomer as well as an unexpected compound with a close Rf value. The compounds were separated and analyzed by nuclear magnetic resonance spectroscopy and mass spectrometry, which revealed the unknown compound to be the bivalent N,N-bis(hexyl α-d-acetylmannosyl) acrylamide monomer, which contains two hexyl mannose units and one acrylamide group. To the best of our knowledge, this side reaction has not previously been disclosed, and may be useful for the construction of multivalent sugar ligands.

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