Serum Glucose, Lipid Profile and Oxidative Stress Markers of Salt-induced Metabolic Syndrome Rats Administered Antioxidant Rich Nutraceutical

Metabolic syndrome (MetS) is characterized by increased oxidative stress and a pro-inflammatory state. Vaccinium meridionale Swartz (known as “agraz”) is a berry rich in polyphenolic compounds with demonstrated antioxidant activity and anti-inflammatory effects in preclinical studies. The aim of this study was to evaluate the effects of agraz consumption on inflammatory and oxidative stress markers in women with MetS. Forty women with MetS (47 ± 9 years) were randomly assigned to consume daily either 200 mL of agraz nectar or placebo over four weeks in a double-blind, cross-over design study, separated by a 4-week washout period. Metabolic and inflammatory markers in serum and antioxidant/oxidative stress markers in serum and urine were assessed at the end of each period. Serum antioxidant capacity measured by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method was significantly higher (p = 0.028), while urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) was lower (p = 0.041) after agraz consumption, compared to placebo. In conclusion, consumption of agraz during four weeks increased serum antioxidant capacity and decreased a marker of DNA oxidative damage in women with MetS, compared to placebo. These results suggest that agraz consumption may play a protective role in patients with MetS.

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Association of Inflammatory and Oxidative Stress Markers with Metabolic Syndrome in Asian Indians in India

Cardiology Research and Practice ◽

10.4061/2011/295976 ◽

2011 ◽

Vol 2011 ◽

pp. 1-8 ◽

Cited By ~ 3

Author(s):

Veena S. Rao ◽

Radhika K. Nagaraj ◽

Sridhara Hebbagodi ◽

Natesha B. Kadarinarasimhiah ◽

Vijay V. Kakkar

Keyword(s):

Oxidative Stress ◽

Metabolic Syndrome ◽

Oxidative Stress Markers ◽

Stress Markers ◽

Candidate Predictor ◽

Asian Indian Population ◽

Atherosclerosis Research ◽

And Oxidative Stress ◽

Primary Risk Factor

Metabolic syndrome (MetS) is a primary risk factor for cardiovascular disease and is associated with a proinflammatory state. Here, we assessed the contribution of inflammatory and oxidative stress markers towards prediction of MetS. A total of 2316 individuals were recruited in Phase I of the Indian Atherosclerosis Research Study (IARS). Modified ATPIII guidelines were used for classification of subjects with MetS. Among the inflammatory and oxidative stress markers studied, levels of hsCRP (P<.0001), Neopterin (P=.036), and oxLDL (P<.0001) were significantly higher among subjects with MetS. Among the markers we tested, oxLDL stood out as a robust predictor of MetS in the IARS population (OR 4.956 95% CI 2.504–9.810;P<.0001) followed by hsCRP (OR 1.324 95% CI 1.070–1.638;P=.010). In conclusion, oxLDL is a candidate predictor for MetS in the Asian Indian population.

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Relationship Between C-Reactive Protein and Atherosclerotic Risk Factors and Oxidative Stress Markers Among Young Persons 10–18 Years Old

Clinical Chemistry ◽

10.1373/clinchem.2006.073668 ◽

2007 ◽

Vol 53 (3) ◽

pp. 456-464 ◽

Cited By ~ 37

Author(s):

Roya Kelishadi ◽

Mohsen Sharifi ◽

Alireza Khosravi ◽

Khosrow Adeli

Keyword(s):

Oxidative Stress ◽

Blood Pressure ◽

Metabolic Syndrome ◽

Young People ◽

Hdl Cholesterol ◽

Oxidative Stress Markers ◽

C Reactive Protein ◽

Reactive Protein ◽

Stress Markers ◽

And Oxidative Stress

AbstractBackground: This study was undertaken to determine the association of serum C-reactive protein (CRP) with generalized and abdominal obesity, body fat composition, the metabolic syndrome, and oxidative stress markers among young people.Methods: We conducted a population-based study of 512 young people, aged 10–18 years. We obtained anthropometric and blood pressure measurements. Fasting blood sugar, total cholesterol (TC), HDL-cholesterol, triglycerides, CRP, malondialdehyde (MDA), and conjugated diene (CDE) were quantified. LDL-cholesterol (LDL-C) was calculated for samples with TG ≤4.52 mmol/LResults: Mean triglycerides, waist and hip circumferences, percentage body fat, subcutaneous fat, and systolic blood pressure increased significantly with increasing body mass index (BMI). In contrast, the mean LDL and TC were higher in underweight than normal weight individuals, and then increased significantly from normal to higher BMI categories. Mean HDL cholesterol significantly decreased with increasing BMI. Overall, CRP, MDA, and CDE were significantly correlated with measures of abdominal obesity. Serum CRP, MDA, and CDE significantly increased in the upper quartiles of waist circumference. Study participants with higher CRP concentrations were more likely to have metabolic syndrome and high oxidative stress markers.Conclusion: We found a significant positive association between CRP and oxidative stress markers in healthy young people, as well as an increase in these markers in the upper quartiles of waist circumference, but not BMI. Oxidative stress and CRP may interact in the early inflammatory processes of atherosclerosis.

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