Evaluation of the Effectiveness of the use of Pantoprazole and the Risks

Journal of Advances in Medicine and Medical Research ◽

10.9734/jammr/2021/v33i1530984 ◽

2021 ◽

pp. 35-41

Author(s):

R. V. Anil Kumar ◽

P. Dwarakanadha Reddy

Keyword(s):

Andhra Pradesh ◽

Prospective Observational Study ◽

Tertiary Care ◽

Electrolyte Imbalance ◽

Policy Makers ◽

H2 Receptor Blockers ◽

Receptor Blockers ◽

Special Space ◽

Significant Health

Drug use evaluation (DUE) is a systematic approach to study the utilization of marketed drugs. These studies are proved invaluable for policy makers to get inputs on the use of drugs so that they can review their strategies. In this prospective observational study, we have conducted a DUE of Acid suppressant drugs in Outpatient department (OPD) of a tertiary care teaching hospital in Kadapa, Andhra Pradesh. In the armamentarium of acid suppressants Proton pump inhibitors (PPIs) occupied a special space owing to their superiority to others like H2 receptor blockers. PPIs are in the market for the last 40 years and their safety and efficacy is impeccable till now. These are the most commonly used drugs and tend to be used for long-term to manage acidity problems. But unregulated usage of PPIs over long term could pose very significant health problems ranging from electrolyte imbalance to cognitive impairment. Our study identified some issues in prescribing PPIs suggesting there is generous use of PPIs without considering their risks. And their safety also taken for granted, it appears.

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A prospective observational study of prescription appropriateness of elderly hypertensive patients using Beers criteria in a tertiary care teaching hospital

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20174768 ◽

2017 ◽

Vol 6 (11) ◽

pp. 2545 ◽

Cited By ~ 1

Author(s):

Supriya K. H. ◽

Shashi Kumar N. S. ◽

Prakash G. M. ◽

Sareetha A. V.

Keyword(s):

Observational Study ◽

Prospective Observational Study ◽

Angiotensin Receptor Blockers ◽

Inappropriate Medication ◽

Tertiary Care ◽

Electrolyte Imbalance ◽

Beers Criteria ◽

Hypertensive Patients ◽

Elderly Hypertensive ◽

Elderly Hypertensive Patients

Background: The prevalence of hypertension has been increased among the urban population especially among the elderly. Use of inappropriate medication is one of the major problems seen among elderly age group above 60 years who take more medication when compared to that of younger population. Inappropriate prescriptions can be avoided by identifying safer pharmacological alternatives and also utilizing non-pharmacological therapy. Quality and safety of prescribing in elderly patients is one of the global healthcare concern and efforts should be made to improve appropriateness of medication among this group of population. This study was done to assess the relationship between inappropriate medication use and its health outcomes in elderly hypertensive population.Methods: A prospective observational study was conducted over a period of 3 months, after getting approval from Institutional Ethics Committee. Total of 117 elderly hypertensive patients aged >60 years were analysed for three months duration for the rationality of medication prescribed using Beer’s criteria and the health outcome due to inappropriate medication use.Results: Out of 117 elderly hypertensive patients analysed, 49 (41.9%) were males and 68 (58.1%) were females. Most of the patients had associated co morbid illness like diabetes mellitus (48.7%), respiratory diseases (24.8%), cerebrovascular accident (30.8%), cardiovascular diseases (19.7%), fever (13.7%), anaemia (9.4%), etc. Out of 117 patients <5 drugs were used in 6.8%, 5 -10 drugs were used in 89.7% and >10 drugs were used in 3.4% of cases. Antihypertensive drugs that were commonly used in our study was calcium channel blocker (52.1%), diuretics (42.7%), Angiotensin converting enzyme inhibitors (36.8%), β-blockers (17.1%) and Angiotensin receptor blockers (11.1%). Adverse health effects like drug induced gastritis, electrolyte imbalance, metabolic dysfunction and renal impairment was seen in few patients because of inappropriate medication.Conclusions: Use of inappropriate medication is one of the major problems seen among elderly, because of the co morbid illness associated with the primary disease which leads to polypharmacy. Prescription inappropriateness was seen among 86.3% of elderly hypertensive patients as per Beers criteria which may be because of comorbid illness that was seen among these patients. It is necessary to implement certain policies in geriatric healthcare to prevent the poor outcome due to drug therapy.

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Effect of long-term acid suppression therapy with proton pump inhibitors or H2 receptor blockers on serum vitamin B12 levels in elderly population

Irish Journal of Medical Science (1971 -) ◽

10.1007/s11845-020-02399-w ◽

2020 ◽

Author(s):

Srinivasan Damodharan ◽

Gerard Marshall Raj ◽

M Sakthibalan ◽

Karthikeyan Dakshinamoorthy ◽

P Muraliswaran

Keyword(s):

Vitamin B12 ◽

Proton Pump Inhibitors ◽

Proton Pump ◽

Elderly Population ◽

Serum Vitamin ◽

Acid Suppression ◽

H2 Receptor Blockers ◽

Acid Suppression Therapy ◽

Receptor Blockers

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LONG-TERM SAFETY OF CONCOMITANT USE OF PROTON PUMP INHIBITORS AND H2 RECEPTOR BLOCKERS WITH THIENOPYRIDINES IN THE SETTING OF CORONARY STENTING

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(14)60226-6 ◽

2014 ◽

Vol 63 (12) ◽

pp. A226

Author(s):

Matthew Butler ◽

Christopher Buckley ◽

Calvin Madrigal ◽

Arun Raghav Mahankali Sridhar ◽

Buddhadeb Dawn

Keyword(s):

Proton Pump Inhibitors ◽

Proton Pump ◽

Coronary Stenting ◽

H2 Receptor ◽

H2 Receptor Blockers ◽

Receptor Blockers

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Rising trends and indication of Caesarean section in Indonesia

World Nutrition Journal ◽

10.25220/wnj.v04.s2.0001 ◽

2020 ◽

Vol 4 (1-2) ◽

pp. 1

Author(s):

Ali Sungkar ◽

Ray Wagiu Basrowi

Keyword(s):

Caesarean Section ◽

Caesarean Delivery ◽

Economic Status ◽

Tertiary Care ◽

Short Term ◽

Policy Makers ◽

National Surveys ◽

Increasing Trend ◽

Elective Procedure

The rate of Caesarean delivery is rising dramatically worldwide, and also nationally. The number of Caesarean births exceeds the WHO recommended rate. This study aims to provide an overview of current increasing trend of Caesarean section, including elective procedure, and its risk. A review was conducted using online database, surveillance reports, and national surveys to identify studies with topics of prevalence, trend, indications, and risks of Caesarean delivery. Overall, there is an increase of Caesarean section in global, Asia, and Indonesia setting. We found an increase of 8% from 2013 to 2018 based on population survey, and increase of elective Caesarean surgery, particularly in tertiary care. We listed the possible health risks in short term, long term among mothers and child. Advanced maternal age, higher socio-economic status, higher educational level, residing in urban area, and ownership of health insurance were found to be factors associated with maternal choice on Caesarean delivery. The information presented is important to raise awareness among policy makers aimed to develop a national strategy in reducing the rate of Caesarean delivery.

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Evaluation of Electrolyte Imbalance in Patients With Traumatic Brain Injury Admitted in the Central ICU of a Tertiary Care Centre: A Prospective Observational Study

Cureus ◽

10.7759/cureus.17517 ◽

2021 ◽

Author(s):

Sandeep Dey ◽

Ramesh Kumar ◽

Abhijit Tarat

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Observational Study ◽

Prospective Observational Study ◽

Tertiary Care ◽

Electrolyte Imbalance ◽

Care Centre ◽

Tertiary Care Centre

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HYPONATREMIA IN CHILDREN OF 2 MONTHS TO 5 YEARS OF AGE WITH PNEUMONIA AND ITS CORRELATION WITH OUTCOME

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v4i5.1120 ◽

2020 ◽

Vol 4 (5) ◽

Author(s):

Kapil Kumar ◽

Anita Devi ◽

Rakes Kumar Sharma

Keyword(s):

Observational Study ◽

Serum Sodium ◽

Prospective Observational Study ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Severe Pneumonia ◽

Electrolyte Imbalance ◽

Care Hospital ◽

Keywords Children ◽

Who Criteria

Background: Hyponatremia is a common electrolyte imbalance observed in children with pneumonia. Presence of hyponatremia may increase the morbidity and mortality in pneumonia. The purpose of the study was to find the frequency of hyponatremia in 2 months to 5 years old children hospitalized with pneumonia and to correlate the hyponatremia with the severity of pneumonia. Methods: This prospective observational study involved 100 children of 2 months to 5 years, admitted in tertiary care hospital with pneumonia. Subjects were classified as pneumonia and severe pneumonia according to WHO criteria. Relevant demographic, clinical data and outcome of the patients were noted. Serum sodium was analyzed and was correlated with severity of pneumonia. Results: Out of 100 children included in this study, 64 were boys and 36 were girls. Hyponatremia was found in 43.0% of children with pneumonia. Mild hyponatremia was the commonest and seen in 26 children. Mortality was more in children with hyponatremia compared to normonatremia. Conclusion: Hyponatremia is a common electrolyte imbalance found in pneumonia and more commonly seen in severe pneumonia. Hyponatremia is associated with increased mortality. Keywords: Children, Hyponatremia, Mortality, Pneumonia.

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