Regulatory Aspects of Omega Polyunsaturated Fatty Acids in Dietary Supplements

2017 ◽  
Vol 18 (2) ◽  
pp. 1-7 ◽  
Author(s):  
Valentina Petkova ◽  
Danka Obreshkova ◽  
Bozhidarka Hadzhieva ◽  
Stefka Ivanova
Author(s):  
A. I. Fedosov ◽  
V. S. Kyslychenko ◽  
O. M. Novosel

Introduction. Polyunsaturated fatty acids show a wide spectrum of biological activity in human body, including lowering blood cholesterol level, arterial pressure, improving blood circulation, take part in prostaglandins synthesis etc. Thus, the search of new herbal sources of polyunsaturated fatty acids is an important task of modern pharmaceutical science aimed at creation of effective Ukrainian medicines and dietary supplements on their basis.The aim of the study – to learn of qualitative composition and quantitative content of fatty acids in garlic leaves and bulbs.Research Methods. The fatty acid composition of garlic leaves and bulbs was carried out using gas chromatography.Results and Discussion. As a result of the research 13 fatty acids were identified and their content was determined in garlic leaves, and 11 fatty acids – in garlic bulbs. Among the saturated fatty acids palmitic acid dominated in the leaves – 17.85 % and in bulbs – 13.67 %, and among unsaturated ones – linoleic acid – 46.40 % and 64.45 % respectively. The sum of unsaturated fatty acids both in the leaves and bulbs prevailed over the sum of saturated ones, which allows to expect hypocholesteremic, hypolipidemic, antiaggregant and hypotensive activity in the medicines containing the studied plant material types.Conclusions. 1. The fatty acid composition of garlic leaves and bulbs was carried out using gas chromatography. As a result of the research 13 fatty acids were identified and their content was determined in garlic leaves, and 11 fatty acids – in garlic bulbs. The sum of unsaturated fatty acids both in the leaves and bulbs prevailed over the sum of saturated ones, with prevalence of linoleic acid – 46,40% in the leaves and 64.45 % in bulbs. The obtained results allow recommending garlic leaves and bulbs as herbal source of polyunsaturated fatty acids with the following creation of effective Ukrainian medicines and dietary supplements on their basis.


2021 ◽  
Vol 247 ◽  
pp. 01031
Author(s):  
Irina Khamagaeva ◽  
Natalya Zambalova ◽  
Aleksandra Tsyzhipova ◽  
Aleksey Bubeev ◽  
Olga Bogdanova

For the first time, we have studied the influence of polyunsaturated fatty acids on cholesterol metabolizing activity of bifidobacteria. High levels of destruction of cholesterol in the process of cultivation of strain Bifidobacterium Longum DK 100 was noted. Based on the results, the technology of probiotic dietary supplements (DS), enriched with polyunsaturated fatty acids, has been developed. The paper reveals that the introduction of probiotic DS leads to a twofold reduction in total cholesterol in the experimental groups in comparison with the control one, which indicates high effectiveness of DS. It has been observed that against the background of the atherogenic diet, the employment of probiotic DS is accompanied by a significant reduction in triglyceride levels by 37% and 45% in the "linen" and "cedar" groups, respectively, compared to the control group of animals. It has been established that in the blood serum of animals of experimental groups, the level of high-density lipoproteins increases by 45% in "linen" and 40% in "cedar" groups, while low-density lipoproteins decreased by 19% and 23% respectively. With the introduction of probiotic DS with linseed oil, the atherogenic index decreases by 83%, and with the cedar one by 86%. The results confirm the hypocholesterinemic effect of DS during cholesterol loading.


1981 ◽  
Vol 45 (3) ◽  
pp. 613-616 ◽  
Author(s):  
T. A. B. Sanders ◽  
Katherine M. Younger

1. The effects of dietary supplements of ω 3 polyunsaturated fatty acids on the fatty acid composition of platelets and plasma choline phosphoglycerides were studied in vegans and in omnivores.2. A supplement of 18:3ω3 led to an increase in 20:5 ω3 but was less effective than one of 20:5ω3+22:6ω3.


1972 ◽  
Vol 50 (7) ◽  
pp. 1033-1034 ◽  
Author(s):  
S. N. Thompson ◽  
J. S. Barlow

Dietary supplements of stearic, palmitoleic, and linoleic acids, as representative of saturated, mono-unsaturated, and polyunsaturated fatty acids, respectively, did not appreciably affect the relative composition of fatty acids in waxmoth larvae. Frass analysis demonstrated that most of the fatty acids in excess of their relative composition in the insect are excreted and speculations are made as to the possible mechanism involved in the retention of the characteristic fatty acid pattern.


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