scholarly journals Design, Formulation, and Physicochemical Evaluation of Occimum sanctum Containing Honey Based Hydrogel

2021 ◽  
pp. 33-38
Author(s):  
Akhilesh Shewale ◽  
Sneha Pur ◽  
Rashmi Bele ◽  
Mahvash Fatema
Keyword(s):  
Clinical Application ◽  
In Vitro Release ◽  
Antibacterial Properties ◽  
Topical Preparation ◽  
Physicochemical Evaluation ◽  
Dialysis Method ◽  
Hydrogel Formulation ◽  
Vitro Release

Background and Aim: The present study aims to formulate a hydrogel containing Tulsi (O. sanctum) and honey, to obtain a pharmaceutical topical preparation having desirable healing effects and antibacterial properties of both the ingredients. Material and Method: Topical honey hydrogel formulation were prepared using 75%honey and 10% Occimum sanctum (Tulsi) with polymer carbopol 934. The prepared formulation was assessed for its pH, spreadability, swelling index and in-vitro release Result: The pH and spreadability were in the range of 4.74 ± 0.02 and 7.75 ± 0.04 cm respectively. Carbopol based Honey –Tulsi Formulation showed a concentration-dependent increase in the amount of honey and O. sanctum diffused through dialysis method. Conclusion: Within the limitations of the study, the results of our present study suggest that the studied Honey –Tulsi based hydrogel could be an economic indigenous substitute which is non-toxic, natural and efficient for clinical application.

Preparation and In-vitro Evaluation of Fe3O4 Encapsulated by Chitosan Loaded Capecitabine Nanoparticles for the Treatment of Breast Cancer

2016 ◽  
Vol 6 (3) ◽  
Author(s):  
Shanmuganathan S. ◽  
Nigma S. ◽  
Anbarasan B. ◽  
Harika B.
Keyword(s):  
Fe3o4 Nanoparticles ◽  
Polymer Concentration ◽  
In Vitro Release ◽  
Entrapment Efficiency ◽  
In Vitro Evaluation ◽  
Sem Image ◽  
Therapeutic Molecules ◽  
Dialysis Method ◽  
Vitro Release

Nanoparticulate Carriers which is biodegradable, biocompatible and bio adhesive have significant feasible applications for administration of therapeutic molecules. The present study was aimed to formulate and optimise Capecitabine loaded Chitosan-Fe3O4 Nanoparticles and to study the in-vitro evaluation by sigma dialysis method. Capecitabine loaded chitosan – Fe3O4 nanoparticles batches with different ratios of drug: polymer (1:1, 1:2, 1:3, 1:4, 1:5, 1:6) were prepared by ionic gelation method. Increase in polymer concentration increases the nanoparticle drug content. Entrapment efficiency was 60.12% with drug to polymer ratio F3 (1:3). In-vitro release was found to be 65.20% for 12 hrs. Capecitabine from chitosanFe3O4 nanoparticles SEM image reveals discrete spherical structure and particles with size range of 100-500nm. FTIR studies represent the functional groups present with no characteristics change in formulations. Samples stored at refrigerator conditions showed better stability compared with samples kept at other conditions during 8 weeks of storage.

scholarly journals Microencapsulation of Thymol in Poly(lactide-co-glycolide) (PLGA): Physical and Antibacterial Properties

Materials ◽  
2019 ◽  
Vol 12 (7) ◽  
pp. 1133 ◽  
Author(s):  
Zhu Zhu ◽  
Tiantian Min ◽  
Xueji Zhang ◽  
Yongqiang Wen
Keyword(s):  
Storage Stability ◽  
In Vitro Release ◽  
Antibacterial Properties ◽  
Spherical Shape ◽  
Food Preservative ◽  
And Storage ◽  
Fast Release ◽  
Vitro Release ◽  
And Staphylococcus Aureus

Thymol has been shown to be a safe and effective broad-spectrum antimicrobial agent that can be used as a food preservative. However, its volatile characteristics and strong odor limit its use in food products. The microencapsulation of this essential oil in biopolymers could overcome these disadvantages. In this work, thymol-loaded poly(lactide-co-glycolide) (PLGA) microparticles were successfully prepared and the optimal encapsulation efficiency was obtained at 20% (w/w) thymol. Microparticles containing thymol presented a spherical shape and smooth surface. Microencapsulation significantly improved the thermal and storage stability of thymol. In vitro release profiles demonstrated an initial fast release followed by a slow and sustained release. Thymol-loaded microparticles had strong antibacterial activity against Escherichia coli and Staphylococcus aureus, and the effectiveness of their antibacterial properties was confirmed in a milk test. Therefore, the thymol-loaded microparticles show great potential for use as an antimicrobial and as preservation additives in food.

PREPARATION AND EVALUATION OF BB CONCEALER CREAM CONTAINING NEEM OIL FOR ACNE TREATMENT

INDIAN DRUGS ◽  
2021 ◽  
Vol 58 (11) ◽  
pp. 66-69
Author(s):  
Priyal Jangla ◽  
Khushboo Merai ◽  
Drishti Patel ◽  
Kalyani Sheth ◽  
Keyword(s):  
Inflammatory Disease ◽  
Acne Vulgaris ◽  
In Vitro Release ◽  
Antibacterial Properties ◽  
Neem Oil ◽  
Release Studies ◽  
Acne Treatment ◽  
Preparation And Evaluation ◽  
Vitro Release

Acne vulgaris is a chronic dermatological inflammatory disease with symptoms like redness, comedones and blemishes appearing on face and neck. Propionobacterium acnes plays an important role in this disease. Neem oil, an ayurvedic, anti-bacterial medicine is non-comedogenic. Concealer is a type of cosmetic used to mask and camouflage blemishes and imperfections visible on skin and are available as liquid, balm, cream and stick. BB creams in cosmetics is termed as “beauty balm, blemish base, blemish balm” designed to serve as foundation, moisturizer and sunscreen all at once. The current study was to develop an aesthetic BB cream combining an anti-acne activity with concealing effect. Concentrations of upto 25 %w/w neem oil was prepared and evaluated for appearance, texture, pH, spreadability, antibacterial properties and in vitro release studies. All the formulations confirmed activity against P. acnes. Prolonged activity of neem oil observed at the end of 6 h as demonstrated in vitro

Preparation and In Vitro Release Behaviors of Paclitaxel-Loaded Pluronic F87/Poly(Lactic Acid) Nanoparticle

2014 ◽  
Vol 989-994 ◽  
pp. 102-107
Author(s):  
Zi Ling Li ◽  
You Sheng Huang ◽  
Xiang Yuan Xiong ◽  
Yan Chun Gong ◽  
Yu Ping Li
Keyword(s):  
Lactic Acid ◽  
In Vitro Release ◽  
Bulk Polymerization ◽  
Poly Lactic Acid ◽  
Release Behavior ◽  
Loading Efficiency ◽  
Dialysis Method ◽  
Good Biocompatibility ◽  
Vitro Release

Pluronic F87/Poly (lactic acid) block copolymer (PLA-F87-PLA) was synthesized by bulk polymerization. Paclitaxel-loaded PLA-F87-PLA nanoparcticles were prepared by a dialysis method. The loading efficiency was determined by UV. The results showed that the loading efficiency of paclitaxel for PLA-F87-PLA nanoparticles was 69%. In vitro release behavior of paclitaxel-loaded PLA-F87-PLA nanoparticles was studied by HPLC. In vitro release behavior showed an initial rapid release followed by a slow release. The biocompatibility of nanoparticles was measured by MTT. The viability of paclitaxel-loaded PLA-F87-PLA nanoparticles was less than that of free paclitaxel. The results indicated that PLA-F87-PLA copolymer has good biocompatibility.

Study on in vitro release patterns of fentanyl-loaded PLGA microspheres

2003 ◽  
Vol 20 (5) ◽  
pp. 569-579 ◽  
Author(s):  
S.-A. Seo ◽  
G. Khang ◽  
J. M. Rhee ◽  
J. Kim ◽  
H. B. Lee
Keyword(s):  
In Vitro Release ◽  
Plga Microspheres ◽  
Vitro Release

Reliability of a Single β-Thromboglobulin Measurement in a Diabetic Population : Importance of PGE1 in Anticoagulant Mixture

1987 ◽  
Vol 57 (02) ◽  
pp. 201-204 ◽  
Author(s):  
P Y Scarabin ◽  
L Strain ◽  
C A Ludlam ◽  
J Jones ◽  
E M Kohner
Keyword(s):  
In Vitro Release ◽  
Mean Value ◽  
Reliable Estimate ◽  
Diabetic Patients ◽  
Single Measurement ◽  
Diabetic Population ◽  
The Difference ◽  
Vitro Release

SummaryDuring the collection of samples for plasma β-thromboglobulin (β-TG) determination, it is well established that artificially high values can be observed due to in-vitro release. To estimate the reliability of a single β-TG measurement, blood samples were collected simultaneously from both arms on two separate occasions in 56 diabetic patients selected for a clinical trial. From each arm, blood was taken into two tubes containing an anticoagulant mixture with (tube A) and without (tube B) PGE!. The overall mean value of B-TG in tube B was 1.14 times higher than in tube A (p <0.01). The markedly large between-arms variation accounted for the most part of within-subject variation in both tubes and was significantly greater in tube B than in tube A. Based on the difference between B-TG values from both arms, the number of subjects with artifically high B-TG values was significantly higher in tube B than in tube A on each occasion (overall rate: 28% and 14% respectively). Estimate of between-occasions variation showed that B-TG levels were relatively stable for each subject between two occasions in each tube. It is concluded that the use of PGEi decreases falsely high B-TG levels, but a single measurement of B-TG does not provide a reliable estimate of the true B-TG value in vivo.

Formulation and In-vitro Evaluation of Chewable Tablets of Montelukast Sodium

2015 ◽  
Vol 5 (3) ◽  
Author(s):  
Laxman Devkota ◽  
Bhupendra Poudel ◽  
Junu Silwal
Keyword(s):  
In Vitro Release ◽  
Magnesium Stearate ◽  
Physical Parameters ◽  
Artificial Sweetener ◽  
Leukotriene Receptor Antagonist ◽  
Montelukast Sodium ◽  
Chewable Tablets ◽  
Leukotriene Receptor ◽  
Vitro Release

The objective of the present study is to develop chewable tablets containing different pharmaceutical compositions with simple manufacturing procedures using different excipients. Mannitols, L-HPC 11, Aspartame, Crospovidone, Crospovidone, Aerosil, and Magnesium Stearate are used as excipients for effective formulation of anti-asthmatic drug Montelukast. Montelukast is a selective, orally acting leukotriene receptor antagonist that is used for the treatment of asthma and seasonal allergic rhinitis. Montelukast chewable tablets were prepared by Direct Compression methods using suitable excipients. The chewable tablets were better presented using artificial sweetener Aspartame as flavouring agent. A total of forteen formulations were prepared and the granules were evaluated for pre-compression parameters. The formulated tablets were evaluated for post-compression parameters .The results showed that all the physical parameters were within the acceptable limits. The in vitro release study of all the formulations showed good release. The study concludes that aforementioned excipients can be used to design chewable montelukast sodium tablets.

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