scholarly journals Microencapsulation of Thymol in Poly(lactide-co-glycolide) (PLGA): Physical and Antibacterial Properties

Materials ◽  
2019 ◽  
Vol 12 (7) ◽  
pp. 1133 ◽  
Author(s):  
Zhu Zhu ◽  
Tiantian Min ◽  
Xueji Zhang ◽  
Yongqiang Wen
Keyword(s):  
Storage Stability ◽  
In Vitro Release ◽  
Antibacterial Properties ◽  
Spherical Shape ◽  
Food Preservative ◽  
And Storage ◽  
Fast Release ◽  
Vitro Release ◽  
And Staphylococcus Aureus

Thymol has been shown to be a safe and effective broad-spectrum antimicrobial agent that can be used as a food preservative. However, its volatile characteristics and strong odor limit its use in food products. The microencapsulation of this essential oil in biopolymers could overcome these disadvantages. In this work, thymol-loaded poly(lactide-co-glycolide) (PLGA) microparticles were successfully prepared and the optimal encapsulation efficiency was obtained at 20% (w/w) thymol. Microparticles containing thymol presented a spherical shape and smooth surface. Microencapsulation significantly improved the thermal and storage stability of thymol. In vitro release profiles demonstrated an initial fast release followed by a slow and sustained release. Thymol-loaded microparticles had strong antibacterial activity against Escherichia coli and Staphylococcus aureus, and the effectiveness of their antibacterial properties was confirmed in a milk test. Therefore, the thymol-loaded microparticles show great potential for use as an antimicrobial and as preservation additives in food.

Microencapsulation of vitamin D in protein matrices: in vitro release and storage stability

2020 ◽  
Vol 14 (3) ◽  
pp. 1172-1182 ◽  
Author(s):  
Wahab Ali Khan ◽  
Masood Sadiq Butt ◽  
Imran Pasha ◽  
Amer Jamil
Keyword(s):  
Vitamin D ◽  
Storage Stability ◽  
In Vitro Release ◽  
Protein Matrices ◽  
And Storage ◽  
Vitro Release

Nanostructured lipid carriers containing Amphotericin B: Development, in vitro release assay, and storage stability

2018 ◽  
Vol 48 ◽  
pp. 372-382 ◽  
Author(s):  
Rosilene Rodrigues Santiago ◽  
Kattya Gyselle de Holanda e Silva ◽  
Nednaldo Dantas dos Santos ◽  
Julieta Genre ◽  
Viviane Freitas de Oliveira Lione ◽  
...  
Keyword(s):  
Amphotericin B ◽  
Storage Stability ◽  
In Vitro Release ◽  
Nanostructured Lipid Carriers ◽  
Release Assay ◽  
Development In Vitro ◽  
And Storage ◽  
Vitro Release

Microencapsulation of fish oil using thiol-modified β-lactoglobulin fibrils/chitosan complex: A study on the storage stability and in vitro release

2018 ◽  
Vol 80 ◽  
pp. 186-194 ◽  
Author(s):  
Hon Weng Chang ◽  
Tai Boon Tan ◽  
Phui Yee Tan ◽  
Faridah Abas ◽  
Oi Ming Lai ◽  
...  
Keyword(s):  
Fish Oil ◽  
Storage Stability ◽  
In Vitro Release ◽  
Β Lactoglobulin ◽  
Vitro Release

PREPARATION AND EVALUATION OF BB CONCEALER CREAM CONTAINING NEEM OIL FOR ACNE TREATMENT

INDIAN DRUGS ◽  
2021 ◽  
Vol 58 (11) ◽  
pp. 66-69
Author(s):  
Priyal Jangla ◽  
Khushboo Merai ◽  
Drishti Patel ◽  
Kalyani Sheth ◽  
Keyword(s):  
Inflammatory Disease ◽  
Acne Vulgaris ◽  
In Vitro Release ◽  
Antibacterial Properties ◽  
Neem Oil ◽  
Release Studies ◽  
Acne Treatment ◽  
Preparation And Evaluation ◽  
Vitro Release

Acne vulgaris is a chronic dermatological inflammatory disease with symptoms like redness, comedones and blemishes appearing on face and neck. Propionobacterium acnes plays an important role in this disease. Neem oil, an ayurvedic, anti-bacterial medicine is non-comedogenic. Concealer is a type of cosmetic used to mask and camouflage blemishes and imperfections visible on skin and are available as liquid, balm, cream and stick. BB creams in cosmetics is termed as “beauty balm, blemish base, blemish balm” designed to serve as foundation, moisturizer and sunscreen all at once. The current study was to develop an aesthetic BB cream combining an anti-acne activity with concealing effect. Concentrations of upto 25 %w/w neem oil was prepared and evaluated for appearance, texture, pH, spreadability, antibacterial properties and in vitro release studies. All the formulations confirmed activity against P. acnes. Prolonged activity of neem oil observed at the end of 6 h as demonstrated in vitro

scholarly journals Design, Formulation, and Physicochemical Evaluation of Occimum sanctum Containing Honey Based Hydrogel

2021 ◽  
pp. 33-38
Author(s):  
Akhilesh Shewale ◽  
Sneha Pur ◽  
Rashmi Bele ◽  
Mahvash Fatema
Keyword(s):  
Clinical Application ◽  
In Vitro Release ◽  
Antibacterial Properties ◽  
Topical Preparation ◽  
Physicochemical Evaluation ◽  
Dialysis Method ◽  
Hydrogel Formulation ◽  
Vitro Release

Background and Aim: The present study aims to formulate a hydrogel containing Tulsi (O. sanctum) and honey, to obtain a pharmaceutical topical preparation having desirable healing effects and antibacterial properties of both the ingredients. Material and Method: Topical honey hydrogel formulation were prepared using 75%honey and 10% Occimum sanctum (Tulsi) with polymer carbopol 934. The prepared formulation was assessed for its pH, spreadability, swelling index and in-vitro release Result: The pH and spreadability were in the range of 4.74 ± 0.02 and 7.75 ± 0.04 cm respectively. Carbopol based Honey –Tulsi Formulation showed a concentration-dependent increase in the amount of honey and O. sanctum diffused through dialysis method. Conclusion: Within the limitations of the study, the results of our present study suggest that the studied Honey –Tulsi based hydrogel could be an economic indigenous substitute which is non-toxic, natural and efficient for clinical application.

scholarly journals Formulation Strategies to Improve Nose-to-Brain Delivery of Donepezil

Pharmaceutics ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 64 ◽  
Author(s):  
Lupe Carolina Espinoza ◽  
Marcelle Silva-Abreu ◽  
Beatriz Clares ◽  
María José Rodríguez-Lagunas ◽  
Lyda Halbaut ◽  
...  
Keyword(s):  
Ex Vivo ◽  
In Vitro Release ◽  
Spherical Shape ◽  
Release Profile ◽  
In Vivo Models ◽  
Tablet Form ◽  
Ex Vivo Permeation ◽  
Vitro Release

Donepezil (DPZ) is widely used in the treatment of Alzheimer’s disease in tablet form for oral administration. The pharmacological efficacy of this drug can be enhanced by the use of intranasal administration because this route makes bypassing the blood–brain barrier (BBB) possible. The aim of this study was to develop a nanoemulsion (NE) as well as a nanoemulsion with a combination of bioadhesion and penetration enhancing properties (PNE) in order to facilitate the transport of DPZ from nose-to-brain. Composition of NE was established using three pseudo-ternary diagrams and PNE was developed by incorporating Pluronic F-127 to the aqueous phase. Parameters such as physical properties, stability, in vitro release profile, and ex vivo permeation were determined for both formulations. The tolerability was evaluated by in vitro and in vivo models. DPZ-NE and DPZ-PNE were transparent, monophasic, homogeneous, and physically stable with droplets of nanometric size and spherical shape. DPZ-NE showed Newtonian behavior whereas a shear thinning (pseudoplastic) behavior was observed for DPZ-PNE. The release profile of both formulations followed a hyperbolic kinetic. The permeation and prediction parameters were significantly higher for DPZ-PNE, suggesting the use of polymers to be an effective strategy to improve the bioadhesion and penetration of the drug through nasal mucosa, which consequently increase its bioavailability.

Liposomes as delivery systems for carotenoids: comparative studies of loading ability, storage stability and in vitro release

2014 ◽  
Vol 5 (6) ◽  
pp. 1232 ◽  
Author(s):  
Chen Tan ◽  
Jin Xue ◽  
Xiaowei Lou ◽  
Shabbar Abbas ◽  
Yu Guan ◽  
...  
Keyword(s):  
Comparative Studies ◽  
Storage Stability ◽  
In Vitro Release ◽  
Delivery Systems ◽  
Vitro Release

scholarly journals Berberine encapsulated nanoparticles stimulate osteoblast differentiation in vitro

2021 ◽  
Vol 18 (4) ◽  
pp. 633-641
Author(s):  
Nguyen Thi Hong Minh ◽  
Tran Tuan Anh ◽  
Le Thi Thuy Duong ◽  
Nguyen Viet Linh ◽  
Nguyen Thi Mai Phuong
Keyword(s):  
Osteoblast Differentiation ◽  
Viral Infections ◽  
Mental Disease ◽  
In Vitro Release ◽  
Spherical Shape ◽  
Beneficial Effects ◽  
Mean Size ◽  
Vitro Release ◽  
Stimulate Osteoblast Differentiation

Berberine has been known as a traditional component for treatment of intestinal-related diseases in Asian countries. Additionally, it possesses a variety of pharmacological properties, which were studied for treating tumor, diabetes, cardiovascular disease, hyperlipidemia, inflammation, bacterial and viral infections, cerebral ischemia trauma, and mental disease. Moreover, berberine has been known as an anti-osteoporotic agent by controlling both osteoclast (bone resorption cells) and osteoblast (bone-forming cells) functions. Beside the beneficial effects of berberine, it has some drawbacks that hindered its applications and resulted in low bioavailability. One of the most drawback characteristics of berberine is that it has poor watery solubility. To overcome these limits, nanotechnology has been used as the primary approach to deliver berberine in different nano-formulations. In this study, a novel berberine nanoparticle (nanoberberine, NBB) with good water dispersion was synthesized to enhance its bioavailability. The result showed that NBB was successfully developed in spherical shape and approximately 559 nm of mean size. Besides, in vitro release study revealed that berberine content release from NBB was 3 to 4 times higher than that from free berberine. Moreover, no cytotoxicity was observed for both NBB and berberine on osteoblast MC3T3-E1 cells at the tested concentrations. Additionally, alkaline phosphatase (ALP) activity, a marker for osteoblast differentiation process, was significantly higher in NBB compared to free berberine at the same test concentrations. This result indicated that NBB could be a potential biological agent for inducing bone formation. Overall, our data indicated that NBB could improve bioavailability, especially osteogenesis activity in vitro compared to free berberine.

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