scholarly journals Synthetic Advances against Coronaviruses: A Short Review of the Recent Literature on Newly Synthetized Derivatives and Recently Developed Strategies

Author(s):  
Weiam Hussein ◽  
Fawaz Alheibshy ◽  
Farhan Alshammari

The coronavirus pandemic is a modern social emergency and the biggest global challenge since the Second World War. Since the pandemic began in China at the end of 2019, the disease spread to every landmass except Antarctica. The effect of antiviral drugs on the new corona virus has been tested, but no basic and complete cure has been found, although there are many drugs such as  interleukin-6 inhibitor,  monoclonal antibody and corticosteroid which remarkably reduced mortality of critically ill COVID-19 patients in a major clinical trial. Although not enough experimental data has been released yet, many researchers have hailed the result as a step in the right direction. In this review, a series of the newly chemical derivatives were synthesized and evaluated against human coronavirus. Many derivatives found to be active in inhibiting the cellular infection of human coronavirus which causes the SARS-CoV-2pandemic. This mini- review summarizes the synthesis of these new antiviral derivatives that target coronaviruses and describes general current strategies and models for developing antiviral drugs. The review aims to provide a starting point for medicinal chemists to synthesize necessary and effective drugs against coronaviruses.

2010 ◽  
Vol 26 (2) ◽  
Author(s):  
Jakob Haahr

I artiklen sættes med afsæt i fjernvandreruten fokus på, hvad det er der gør, at vi i Danmark ikke har samme vandrekultur som i vores nabolande.The Missing LinkA long-distance footpath runs from Kilpisjärvi in northern Finland to Alexandroupolis in Greece. However the track does not cross intact but is interrupted on the island of Funen in Denmark. It is no coincidence that the rupture is in Denmark, nor that it is on Funen. In this article this ‘missing link’ provides the starting point to discuss a walking culture, which in Denmark is notable by its absence.At the beginning of 20th century, thanks to the influence of neighbouring countries, the culture of walking did increasingly make itself felt in Denmark. Longer walks became popular and many Danes embarked on hiking tours, walking for several days and spending the night at special ‘vandrehjem’ (or ‘youth hostels’). Since the Second World War this culture has more or less disappeared, and the question asked here is why?The article is divided in two parts. In the first there is a historical review of the development of the Danish culture of walking from the beginning of 20th century until the late 1930’s. This is followed by a discussion of the circumstances that led to the disappearance of this walking culture, focusing on the long distance footpath. This centres on a jostling for supremacy among sporting factions and on the struggle between various outdoor interests, between different management concerns, and between farmers, the state and local authorities about who should have the right to develop and exploit the landscape in southern Funen area. In this struggle organisations representing outdoor activities have been poorly organized and until now the landscape has primary been developed on the premises of agriculture, industry and urbanism.Today the position and status of outdoor life (friluftsliv) and the culture of hiking are improving. Councils in particular are focusing on health, tourism and attracting new residents´, and there is both a political and a popular will to establish hiking trails. For the long-distance footpath these changes mean that the missing link on Funen now disappears and that the hiking trail across Europe is established.


2020 ◽  
Vol 3 (4) ◽  
pp. 108-132
Author(s):  
Osman Sušić ◽  

This paper covers the period from 1937 to 1945, the period of the establishment and works of the Serbian Cultural Club. The paper will discuss the political circumstances in the Kingdom of Yugoslavia in wich Serbian Cultural Club was founded, as well as the program goals and its activities in Bosnia and Herzegovina. Special emphasis will be put on the period of the Second World War in the Bosnia and Herzegovina and the former common state and the activities of the Serbian Cultural Club in the Second World War. The work and achievement of the program goals of the Serbian Cultural Club in the Second World War will be presented through the work of the Exile Government in London and the activities of the Chetniks Movement in the Bosnia and Herzegovina and the former common state. The Serbian Cultural Club was formed as a form of political association and activity, which included politicians, public workers, scientists, members of various political organizations, representatives of state and parastate bodies and organizations, under the slogan "Serbs for Reunion". The club acted as a unique and homogeneous organization, regardless of the composition of the membership, with the goal of saving Serbia and Serbs. This most clearly expressed his overall activity, composition and degree of influence on state policy. The most important issues of state or Serbian nationalist policy for the interest of the Government were discussed in the Club, so the club had an extensive network of boards and several media. Professor and Rector of the University of Belgrade, Dr. Slobodan Jovanović, was elected the first president of the Serbian Cultural Club. He was the ideological creator of this organization (and he set out the basic tasks and goals of the Club). The vice presidents were Dr. Nikola Stojanović and Dr. Dragiša Vasić, and Dr. Vasa Čubrilović the secretary. Dr. Stevan Moljevic was the president of the board of the Serbian Cultural Club for the Bosnian Krajina, based in Banja Luka. According to Dinić, the initiative for the formation of the Serbian Cultural Club was given by Bosnian-Herzegovinian Serbs Dr. Nikola Stojanović, Dr. Vladimir Čorović, Dr. Vladimir Grčić and Dr. Slobodan Jovanović. The activities of the Serbian Cultural Club can be divided into two stages. The first from its founding in 1936 until the signing of the Cvetković-Maček agreement, and the second from 1939 to 1941. The program of the Serbian Cultural Club was a sum of Greater Serbia programs of all major political parties that operated in Serbia with the help of state institutions. The goals of the Serbian Cultural Club were mainly: expansionist policy of expanding Serbian rule to neighboring areas, denying the national identity of all other Yugoslav nations and exercising the right to self-determination. The program goals of the Serbian Cultural Club were to propagate Greater Serbian ideology. With its program about Greater Serbia and its activities, the Serbian Cultural Club has become the bearer of the most extreme Serbian nationalist aspirations. After the Cvetković-Maček agreement of August 1939, the Serbian Cultural Club demanded a revision of the agreement, calling for a Serbo-Croatian agreement based on ethnic, historical or economic-geographical principles. The adoption of one of these principles was to apply to the entire area inhabited by Serbs. The subcommittees of the Serbian Cultural Club in Bosnia and Herzegovina had the primary task of working to emphasize its Serbian character, and after the Cvetkovic-Macek agreement to form awareness that the whole of Bosnia and Herzegovina should enter the Serbian territorial unit. With the prominent slogan "Wherever there are Serbs - there is Serbia", the Serbs in Bosnia and Herzegovina were marked as the "vigilant guardian of the Serbian national consciousness". The leadership and most of the members of the Serbian Cultural Club joined the Chetnik movement as Draža Mihailović's national ideologues. The policy of the militant Greater Serbia program and Serbian nationalism of the Serbian Cultural Club was accepted as the program of Draža Mihailović's Chetnik movement. Some of Draža Mihailović's most important associates belonged to the Serbian Cultural Club. The main political goals of the Chetnik movement are formulated in several program documents. The starting point in them was the idea of a "Greater and Homogeneous Serbia", which was based on the idea that Serbs should be the leading nation in the Balkans.


2019 ◽  
Author(s):  
Valentina Escotet Espinoza

UNSTRUCTURED Over half of Americans report looking up health-related questions on the internet, including questions regarding their own ailments. The internet, in its vastness of information, provides a platform for patients to understand how to seek help and understand their condition. In most cases, this search for knowledge serves as a starting point to gather evidence that leads to a doctor’s appointment. However, in some cases, the person looking for information ends up tangled in an information web that perpetuates anxiety and further searches, without leading to a doctor’s appointment. The Internet can provide helpful and useful information; however, it can also be a tool for self-misdiagnosis. Said person craves the instant gratification the Internet provides when ‘googling’ – something one does not receive when having to wait for a doctor’s appointment or test results. Nevertheless, the Internet gives that instant response we demand in those moments of desperation. Cyberchondria, a term that has entered the medical lexicon in the 21st century after the advent of the internet, refers to the unfounded escalation of people’s concerns about their symptomatology based on search results and literature online. ‘Cyberchondriacs’ experience mistrust of medical experts, compulsion, reassurance seeking, and excessiveness. Their excessive online research about health can also be associated with unnecessary medical expenses, which primarily arise from anxiety, increased psychological distress, and worry. This vicious cycle of searching information and trying to explain current ailments derives into a quest for associating symptoms to diseases and further experiencing the other symptoms of said disease. This psychiatric disorder, known as somatization, was first introduced to the DSM-III in the 1980s. Somatization is a psycho-biological disorder where physical symptoms occur without any palpable organic cause. It is a disorder that has been renamed, discounted, and misdiagnosed from the beginning of the DSMs. Somatization triggers span many mental, emotional, and cultural aspects of human life. Our environment and social experiences can lay the blueprint for disorders to develop over time; an idea that is widely accepted for underlying psychiatric disorders such as depression and anxiety. The research is going in the right direction by exploring brain regions but needs to be expanded on from a sociocultural perspective. In this work, we explore the relationship between somatization disorder and the condition known as cyberchondria. First, we provide a background on each of the disorders, including their history and psychological perspective. Second, we proceed to explain the relationship between the two disorders, followed by a discussion on how this relationship has been studied in the scientific literature. Thirdly, we explain the problem that the relationship between these two disorders creates in society. Lastly, we propose a set of intervention aids and helpful resource prototypes that aim at resolving the problem. The proposed solutions ranged from a site-specific clinic teaching about cyberchondria to a digital design-coded chrome extension available to the public.


BMC Biology ◽  
2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Andra Waagmeester ◽  
Egon L. Willighagen ◽  
Andrew I. Su ◽  
Martina Kutmon ◽  
Jose Emilio Labra Gayo ◽  
...  

Abstract Background Pandemics, even more than other medical problems, require swift integration of knowledge. When caused by a new virus, understanding the underlying biology may help finding solutions. In a setting where there are a large number of loosely related projects and initiatives, we need common ground, also known as a “commons.” Wikidata, a public knowledge graph aligned with Wikipedia, is such a commons and uses unique identifiers to link knowledge in other knowledge bases. However, Wikidata may not always have the right schema for the urgent questions. In this paper, we address this problem by showing how a data schema required for the integration can be modeled with entity schemas represented by Shape Expressions. Results As a telling example, we describe the process of aligning resources on the genomes and proteomes of the SARS-CoV-2 virus and related viruses as well as how Shape Expressions can be defined for Wikidata to model the knowledge, helping others studying the SARS-CoV-2 pandemic. How this model can be used to make data between various resources interoperable is demonstrated by integrating data from NCBI (National Center for Biotechnology Information) Taxonomy, NCBI Genes, UniProt, and WikiPathways. Based on that model, a set of automated applications or bots were written for regular updates of these sources in Wikidata and added to a platform for automatically running these updates. Conclusions Although this workflow is developed and applied in the context of the COVID-19 pandemic, to demonstrate its broader applicability it was also applied to other human coronaviruses (MERS, SARS, human coronavirus NL63, human coronavirus 229E, human coronavirus HKU1, human coronavirus OC4).


2021 ◽  
pp. 136843102098713
Author(s):  
David Martínez ◽  
Alexander Elliott

According to David Miller, immigration is not a human right. Conversely, Kieran Oberman makes a case for immigration as a human right. We agree with the latter view, but we show that its starting point is mistaken. Indeed, both Miller and Oberman discuss the right to immigration within the liberal paradigm: it is a right or not depending on the correct balance between the interests of the citizens of a given national state and the interests of the immigrants. Instead, we claim that public justification can underpin immigration as a human right. That said, the public justification of the right to immigration has several counterarguments to rebut. Before we deal with that issue, relying on Jürgen Habermas’s social theory, we examine the legal structures that could support the right to immigration in practice. To be sure, this does not provide the normative justification needed, instead it shows the framework that allows the institutional realization of this right. Then, through a combination of civic and cosmopolitan forms of solidarity, the article discusses the formation of a public sphere, which could provide the justification of the right to immigration.


2007 ◽  
Vol 14 (4) ◽  
pp. 313-319
Author(s):  
Benedikt Buchner

AbstractIndustry-sponsored medical education is a much disputed issue. So far, there has been no regulatory framework which provides clear and definite rules as to whether and under what circumstances the sponsorship of medical education is acceptable. State regulation does not exist, or confines itself to a very general principle. Professional regulation, even though applied frequently, is rather vague and indefinite, raising the general question as to whether self-regulation is the right approach at all. Certainly, self-regulation by industry cannot and should not replace other regulatory approaches. Ultimately, advertising law in general and the European Directive 2001/83/EC specifically, might be a good starting point in providing legal certainty and ensuring the independence of medical education. Swiss advertising law illustrates how the principles of the European Directive could be implemented clearly and unambiguously.


2010 ◽  
Vol 2010 ◽  
pp. 1-3 ◽  
Author(s):  
Jagadeesh K. Kalavakunta ◽  
Vishwaroop Bantu ◽  
Hemasri Tokala ◽  
Mihas Kodenchery

Introduction. Brugada syndrome accounts for about 4% of sudden cardiac deaths (SCD). It is characterized by an ST-segment elevation in the right precordial electrocardiogram (EKG) leads.Case Presentation. We describe a 39-year-old healthy Caucasian man who was admitted to the intensive care unit after being cardioverted from ventricular fibrillation (VF) arrest. His past history was significant for an episode of syncope one month prior to this presentation for which he was admitted to an outlying hospital. EKG during that admission showed ST elevations in V1 and V2 leads, a pattern similar to Type 1 Brugada. A diagnosis of Brugada syndrome was missed and the patient had a cardiac arrest a month later. We discuss a short review of Brugada syndrome and emphasize the need to look for it in patients presenting with SCD and malignant arrhythmias.Conclusion. Physicians should always consider Brugada syndrome in the differential diagnosis of ST-segment elevation in anterior precordial leads of EKG and associated VT/VF. Although more than 17 years have passed since the first case was reported, increased awareness of this syndrome is needed to identify patients with EKG changes and treat them accordingly to prevent incidence of (SCD) and its deleterious complications.


Legal Studies ◽  
1995 ◽  
Vol 15 (2) ◽  
pp. 219-235 ◽  
Author(s):  
Peter Luther

When the topic of severance of a beneficial joint tenancy is discussed, most judges and academics start with the case of Williams v Hensman. The judgment of Sir William Page Wood V-C is the ‘locus classicus’, the ‘starting point for any discussion of the modem law’. One paragraph of Page Wood's judgment is quoted in case after case:‘A joint tenancy may be severed in three ways: in the first place, an act of one of the persons interested operating on his own share may create a severance as to that share. The right of each joint tenant is a right by survivorship only in the event of no severance having taken place of the share which is claimed under the jus accrescendi. Each one is at liberty to dispose of his own interest in such a manner as to sever it from the joint fund - losing, of course, at the same time, his own right of survivorship.


Author(s):  
Miško Šuvaković

In what follows, I will point to theorization of concept of the experimental film. My main thesis is that experimental art is based on the project, research practice, innovation and open transgressive or subversive artworks. Art focused on subversion of institutional power features as a singular event performed within a particular social relationship, as a critical actionist, engaged, or activist practice. Transgression – literally – refers to: infraction, violation of a law or an order, while in geological terms it implies penetration and expansion of the sea over the mainland. The notion of transgression relates to excess, overrunning or, more precisely, departing the familiar for the unknown, control for freedom. Experimental art was created in different disciplines such as experimental music, experimental film, experimental theater, etc. John Cage’s concept of ‘experimental music’ has been the starting point for new experimental art and artistic practices since 1950. Experimental film (experimental, new, avant-garde or neo-avant-garde cinema) has featured since the Second World War. The concept and term describe a range of filmmaking styles which are generally quite different from, and often opposed to, the practices of mainstream commercial and documentary filmmaking and entertainment-oriented cinematography. In the second and third part of the essay, I will present an analysis of the experimental films of the artists the OHO group and Neša Paripović. Article received: December 2, 2017; Article accepted: December 18, 2017; Published online: April 15, 2018; Original scholarly paper How to cite this article: Šuvaković, Miško. "Fragments Over Experimental Film: Liminal Zones of Cinema, Art and Theory." AM Journal of Art and Media Studies no 15 (2018): . doi: 10.25038/am.v0i15.225


2012 ◽  
Vol 17 ◽  
pp. 17-32
Author(s):  
Mónika Szente-Varga

The first diplomatic and consular relations were established between Mexico and the Habsburg Empire in the 1800 s, motivated basically by commerdal reasons and dynastic interests. These got to an abrupt end with the execution of Emperor Maximilian in Querétaro in 1867, and diplomatic relations were resumed only decades later, in 1901, which is, in fact, our starting point. This essay examines the development of diplomatic relations between Mexico and Central-Eastern Europe from the beginning of the 20'' centuiy until nowadays. It is divided into chronological chapters, where we study bilateral relations in the coordinates of the following periods: beginning of the century, the period between the two world wars, the Second World War, Cold War and recent years. The investigation in based on documents of the Ministry of Foreign Affairs of Mexico (SRE-AHD) and of the Hungarian National Archive (MOL).


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