scholarly journals Testosterone Correlation with Low and High Density Lipoprotein in Male Type 2 Diabetics

2021 ◽  
pp. 200-206
Author(s):  
Mubeena Laghari ◽  
Shazia Murtaza ◽  
Zuha Talpur ◽  
Mohsina Hamid ◽  
Faryal Adnan ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
Testosterone Level ◽  
Density Lipoprotein ◽  
Serum Testosterone ◽  
High Density ◽  
Assay Method ◽  
Male Type ◽  
Type 2 Diabetics ◽  
Low Serum

Aim: To determine correlation of serum testosterone with low and high density lipoprotein in male type 2 Diabetics presenting at a tertiary care hospital of Sindh.  Methodology: A cross sectional study, Department of Biochemistry and Department of Medicine, Liaquat University Hospital from January 2018 to February 2019. One hundred male type 2 diabetics (cases) and one hundred age matched male (control) were selected through non – probability purposive sampling. Male diagnosed cases of DM belonging to 4th to 6th decade of life was included. Blood samples were collected by venesection and sera were squeezed by centrifugation and stored at – 20 0C in refrigerators. Testosterone was estimated by the ELISA (competitive immuno- assay) assay method and blood lipids - cholesterol, triglycerides (TAGs), LDLc and HDLc by colorimetric method. Pearson`s correlation was generated on Statistical software SPSS 21.0 version (IBM, Incorp, USA) for correlation of serum testosterone with lipids fractions (P≤0.05). Results: Age shows majority of male type 2 diabetics were in their 5th decade. We found low serum testosterone level (10.85±4.7 mmol/L) in cases compared to normal testosterone level (13.39±3.8 mmol/L) in control (P=0.0001). Pearson`s correlation shows inverse association with HDLc (r= -0.70) (P=0.0001) and positive association with LDLc (r= 0.670) (P=0.0001). Conclusion: We found low serum testosterone in male type 2 diabetics that showed negative correlation with high density lipoprotein (HDLc) and positive correlation with low density lipoprotein (LDLc).

scholarly journals Efficacy of low-dose rosuvastatin in patients with type 2 diabetes and hypo high-density lipoprotein cholesterolaemia

2014 ◽  
Vol 42 (2) ◽  
pp. 457-467 ◽  
Author(s):  
Takuyuki Katabami ◽  
Mariko Murakami ◽  
Suzuko Kobayashi ◽  
Tomoya Matsui ◽  
Makoto Ujihara ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
High Density Lipoprotein ◽  
Low Dose ◽  
Density Lipoprotein ◽  
High Density

scholarly journals COMPARISON OF SDLDL-C ANALYSIS USING SRISAWASDI METHOD AND HOMOGENEOUS ENZYMATIC ASSAY METHOD ON HYPERTRIGLYCERIDEMIA CONDITION (Perbandingan Analisa sdLDL-C metode Srisawasdi dan Homogeneous Enzymatic Assay di Kondisi Hipertrigliseridemia)

2018 ◽  
Vol 23 (1) ◽  
pp. 74
Author(s):  
Gilang Nugraha ◽  
Soebagijo Poegoeh Edijanto ◽  
Edhi Rianto
Keyword(s):  
High Density Lipoprotein ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Enzymatic Assay ◽  
Assay Method ◽  
Low Density

Small Dense Low Density Lipoprotein (sdLDL) merupakan fraksi terkecil dari partikel Low Density Lipoprotein (LDL) yang memilikidiameter ≤25,5 nm. Partikel sdLDL merupakan lipoprotein sangat aterogenik bahkan telah dilaporkan meningkatkan kebahayaanPenyakit Jantung Koroner (PJK) hingga tiga kali lipat. Pengukuran sdLDL dilakukan dengan alat dan teknik yang rumit sehinggakurang cocok diterapkan dalam praktek klinis sehari-hari. Tahun 2011, Srisawasdi dkk mengembangkan teknik pengukuran perkiraansdLDL-cholesterol (sdLDL-C) menggunakan persamaan dengan menghitung profil lipid rutin. Dilaporkan bahwa peningkatan kepekatantrigliserida (TG) menurunkan kenasaban perkiraan sdLDL-C Srisawasdi. Penurunan nilai kenasaban dapat mempengaruhi ketepatanyang mengakibatkan penurunan mutu pemeriksaan laboratorium. Diambil 88 sampel yang dilakukan pengukuran Total Cholesterol(TC), TG, high density lipoprotein-cholesetrol (HDL-C) dan direk low density lipoprotein-cholesetrol (dLDL-C) di RSUD Dr. Soetomo,sdLDL-C metode homogeneous enzymatic assay dilakukan di Laboratorium Parahita Dharmawangsa. Hasil analisis menunjukkan, tidakada perbedaan hasil periksaan sdLDL-C formula Srisawasdi dkk dengan metode homogeneous enzymatic assay (P=0,000). Penurunannilai kenasaban ditemukan di kelompok kepekatan TG <100 mg/dL sampai dengan kelompok kepekatan TG 200-299 mg/dL. Perbedaannilai kenasaban di setiap kelompok TG tidak mempengaruhi ketepatan pemeriksaan sdLDL-C formula Srisawasdi (P=0,720) hinggakepekatan TG <400 mg/dL, dengan nilai bias pada seluruh sampel yaitu 34,15%. Keterbatasan sdLDL-C formula Srisawasdi dkk hanyadapat digunakan di kepekatan TG kurang dari 200 mg/dL dengan pemantapan mutu intralaboratorium yang terkendali baik. Saranpenelitian, perlu diteliti lebih lanjut untuk menentukan nilai normal sdLDL-C formula Srisawasdi.

Abstract 445: Phospholipid Levels Associated with Specific High-Density Lipoprotein Subfractions Predict Cardiovascular Risk in Young Adults with Type 2 Diabetes

2012 ◽  
Vol 32 (suppl_1) ◽  
Author(s):  
Scott M Gordon ◽  
Amy S Shah ◽  
L J Lu ◽  
Jingyuan Deng ◽  
Lawrence M Dolan ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Risk ◽  
High Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Phospholipid Content ◽  
Healthy Controls ◽  
Carotid Imt ◽  
Early Atherosclerosis

Risk for atherosclerosis is greatly increased in people who have type 2 diabetes (T2D). Because of this, the emerging epidemic of adolescent T2D holds ominous implications for premature cardiovascular disease (CVD). High density lipoprotein cholesterol (HDL-C) represents the body’s natural defense against CVD but its levels are depressed in individuals with T2D. Recent studies indicate HDL exists as distinct subspecies raising the possibility that certain species may be more cardioprotective than others. However, little is known regarding the role of HDL subspecies in T2D, especially in the adolescent population. Thus we sought to evaluate HDL subspecies and determine whether certain subspecies are associated with protection against the development of early atherosclerosis as measured by carotid intima medial thickness (IMT). Healthy controls and youth with T2D were recruited. Whole plasma was analyzed by high-resolution gel filtration chromatography to resolve HDL sized particles and lipids in each fraction were quantitated by colorimetric assay. T-tests were used to evaluate group differences and linear regression models were constructed to determine independent predictors of carotid IMT. Youth with T2D had higher BMI, total cholesterol and lower HDL-C compared to healthy controls, p<0.05. The groups did not differ in LDL-C, triglycerides or BP. Phospholipid distributions of HDL subspecies were found to be shifted in participants with T2D compared to controls (p<0.05). There was a significant inverse correlation between carotid IMT and the phospholipid content of larger HDL subfractions 22-24 (p<0.05) in youth with T2D. Linear models demonstrate HDL fraction 22 was the only independent predictor of carotid IMT while HDL-C, LDL-C, total -C and triglycerides were not significant. These data suggest an altered HDL particle subclass distribution may better predict protection against early atherosclerosis. Thus analyzing the HDL subspecies may be a more powerful approach to assessing cardiovascular risk than the currently accepted standard of HDL-C.

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