scholarly journals The hypoglycemic effect of plant derived insulin like protein in comparison to the hypoglycemic effect of the human soluble insulin in diabetic mice

2014 ◽  
Vol 9 (1) ◽  
pp. 41-48
Author(s):  
Hassan R.J ◽  
◽  
Hadi N.A ◽  
Shayma`A Jamal Ahmed
Keyword(s):  
Hypoglycemic Effect ◽  
Diabetic Mice ◽  
Soluble Insulin

scholarly journals A Phenolic Fraction from Catharanthus roseus L. Stems Decreases Glycemia and Stimulates Insulin Secretion

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Janet Alejandra Espejel-Nava ◽  
Elisa Vega-Avila ◽  
Francisco Alarcon-Aguilar ◽  
Alejandra Contreras-Ramos ◽  
Guadalupe Díaz-Rosas ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Phenolic Compounds ◽  
Chlorogenic Acid ◽  
Gallic Acid ◽  
Catharanthus Roseus ◽  
Chromatographic Analysis ◽  
Hypoglycemic Effect ◽  
Diabetic Mice ◽  
Rinm5f Cells ◽  
Phenolic Fraction

Catharanthus roseus (L.) G. (C. roseus) is a medicinal plant used traditionally for diabetes mellitus control. Several compounds of an alkaloidal nature have been proposed as hypoglycemic principles. However, little attention has been paid to other compounds in this plant that could also participate in this hypoglycemic activity. This study aimed to analyze the hypoglycemic effect of a polyphenolic fraction from C. roseus, as well as its action on insulin secretion and expression in RINm5F cells. Methods. An alkaloid-free aqueous extract was obtained from C. roseus stems. The hypoglycemic effect of different doses of this extract was evaluated in normal and streptozotocin-induced diabetic mice. This extract was fractionated by bipartition, and the resultant fractions were assessed by their hypoglycemic effects. Subsequently, the fraction with the greater hypoglycemic activity was added to the RINm5F cells, and the expression and secretion of insulin were analyzed. The antioxidant activity was determined by the DPPH method and through chromatographic analysis of the most active fraction by HPLC, using an Econosphere C18 column. Results. The aqueous alkaloid-free extract of C. roseus stems significantly reduced blood glucose in normal and diabetic mice. The fractionation of this extract provided three fractions, one of which (a precipitate) showed significant reductions in glycemia at 6 h (48.1 and 64.5% in normal and diabetic mice, respectively). This precipitate contained phenolic compounds and saponins. Its chromatographic analysis showed that it is formed by several phenolic compounds; gallic acid (0.053%) and chlorogenic acid (0.216%) were identified and quantified. Conclusion. The phenolic fraction of C. roseus containing gallic acid and chlorogenic acid had a hypoglycemic effect that may be explained by an increase in insulin secretion.

scholarly journals Hypoglycemic Effect of Prolamin from Cooked Foxtail Millet (Setaria italic) on Streptozotocin-Induced Diabetic Mice

Nutrients ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3452
Author(s):  
Yongxia Fu ◽  
Ruiyang Yin ◽  
Zhenyu Liu ◽  
Yan Niu ◽  
Erhu Guo ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Foxtail Millet ◽  
Hypoglycemic Effect ◽  
Rrna Gene ◽  
Serotonin Level ◽  
Glucose Metabolism Disorders ◽  
Sequencing Analysis ◽  
Diabetic Mice ◽  
Serum Metabolomics

Millet proteins have been demonstrated to possess glucose-lowering and lipid metabolic disorder modulation functions against diabetes; however, the molecular mechanisms underlying their anti-diabetic effects remain unclear. The present study aimed to investigate the hypoglycemic effect of prolamin from cooked foxtail millet (PCFM) on type 2 diabetic mice, and explore the gut microbiota and serum metabolic profile changes that are associated with diabetes attenuation by PCFM. Our diabetes model was established using a high-fat diet combined with streptozotocin before PCFM or saline was daily administrated by gavage for 5 weeks. The results showed that PCFM ameliorated glucose metabolism disorders associated with type 2 diabetes. Furthermore, the effects of PCFM administration on gut microbiota and serum metabolome were investigated. 16S rRNA gene sequencing analysis indicated that PCFM alleviated diabetes-related gut microbiota dysbiosis in mice. Additionally, the serum metabolomics analysis revealed that the metabolite levels disturbed by diabetes were partly altered by PCFM. Notably, the decreased D-Glucose level caused by PCFM suggested that its anti-diabetic potential can be associated with the activation of glycolysis and the inhibition of gluconeogenesis, starch and sucrose metabolism and galactose metabolism. In addition, the increased serotonin level caused by PCFM may stimulate insulin secretion by pancreatic β-cells, which contributed to its hypoglycemic effect. Taken together, our research demonstrated that the modulation of gut microbiota composition and the serum metabolomics profile was associated with the anti-diabetic effect of PCFM.

scholarly journals Hypoglycemic effect and mechanism of honokiol on type 2 diabetic mice

2015 ◽  
pp. 6327 ◽  
Author(s):  
XIN HU ◽  
Jing Sun ◽  
Xueqi Fu ◽  
Ye Liu ◽  
Yongsen Wang ◽  
...  
Keyword(s):  
Hypoglycemic Effect ◽  
Diabetic Mice ◽  
Type 2 Diabetic

scholarly journals Hypoglycemic effect of p-hydroxycinnamic diesters extracted from carnauba wax powder (Copernicia Prunifera) in alloxan-induced diabetic animals

2020 ◽  
Vol 9 (10) ◽  
pp. e509108183
Author(s):  
Vinícius Bandeira Moura ◽  
José Ytalo Gomes da Silva ◽  
Marcelo Oliveira Holanda ◽  
Carla Laíne Silva Lima ◽  
Sandra Machado Lira ◽  
...  
Keyword(s):  
Alternative Therapy ◽  
Positive Control ◽  
Hypoglycemic Effect ◽  
Diabetic Mice ◽  
Control Groups ◽  
Pharmacological Activities ◽  
Standard Drug ◽  
Carnauba Wax ◽  
Ancient Civilizations ◽  
Transmissible Disease

Diabetes is a chronic non-transmissible disease and the number of cases is increasing every year. Plants appear as an alternative therapy since ancient civilizations. Among the species that have promising pharmacological activities are carnauba (Copernicia prunifera (Miller) H. E. Moore). Carnauba wax powder consists of a mixture of heterogenic compounds, among them, p-hydroxycinnamic diesters (HCA). Therefore, this study aimed to investigate the hypoglycemic effect of HCA in alloxan-induced diabetic animals. Therefore, this study was performed with 50 female Swiss mice, distributed in 5 groups (n = 10). The animals of the negative and positive control groups were treated with water: healthy and diabetic mice, respectively; animals of the HCA groups 25 and 50 were diabetic animals and they were treated with the HCA solution at doses of 25 and 50 mg / Kg, respectively; and with metformin, standard drug, at the dose of 200 mg / kg. After 28 days of HCA treatment, a significant hypoglycemic effect was observed in animals treated with HCA at the lowest dose tested (25 mg / kg). In the present study, HCA shown to be a promising compound with good scientific applicability due to the reduction of glycemia of diabetic animals induced by alloxan.

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