Hubungan Antara Penggunaan Cotton Bud Dengan Gangguan Pendengaran Terhadap Pasien Serumen Obsturan Di RS Pertamina Bintang Amin Bandar Lampung

ABSTRACT: THE RELATIONSHIP BETWEEN THE USE OF COTTON BUD AND HEARING DISORDER TO OBSTURAN SERUMEN PATIENTS AT PERTAMINA BINTANG AMIN BANDAR LAMPUNG HOSPITAL Introduction: data presented by Riskesdas (2013) shows that the prevalence of cerumen obstacles in Indonesia is 18.8%. The prevalence at Pertamina Bintang Amin Hospital in Bandar Lampung is 17,205 patients with obstetric cerumen. Cotton buds are commonly used to clean ears from Serumen and cases of itching in the ears in the community. Cotton buds are not only used by adults but also used by children. Purpose: research objectives to determine the relationship between the use of cotton buds with obsturan cerumen at Pertamina Bintang Amin Hospital, Bandar Lampung. Method: this type of research is quantitative, analytic observational design with a cross-sectional approach. The population was 390 patients with obstetric cerumen taken from a questionnaire at Pertamina Bintang Amin Hospital, Bandar Lampung. Retrieval of data using a questionnaire. The data analysis technique used the Chi-square statistical test. Result: showed that out of 390 obsturan cerumen patients, most of the use of cotton buds was not good, namely 200 people (51.3%), most of the use of obscurant cerumen closed the hole, as many as 222 people (56.9%). There is a relationship between the use of cotton buds and obsturan cerumen at Pertamina Bintang Amin Hospital in Bandar Lampung. Conclusion: there is a relationship between the use of cotton buds and obsturan cerumen at Pertamina Bintang Amin Hospital in Bandar Lampung (p-value 0.000, OR 2.459). It is advisable to carry out ear care appropriately so that obstructive cerumen does not arise which can cause hearing loss. Keywords: Cotton Bud, Obstetric Cerumen INTISARI: HUBUNGAN ANTARA PENGGUNAAN COTTON BUD DENGAN GANGGUAN PENDENGARAN TERHADAP PASIEN SERUMEN OBSTURAN DI RS PERTAMINA BINTANG AMIN BANDAR LAMPUNG Latar belakang: ata yang disajikan Riskesdas (2013) bahwa prevalensi kejadian serumen obsturan di Indonesia sebesar 18,8 %. Prevalensi di RS Pertamina Bintang Amin Bandar Lampung mendapatkan pasien serumen obsturan sebanyak 17.205 orang. Cotton bud biasa digunakan untuk membersihkan telinga dari Serumen dan kasus gatal pada telinga di kalangan masyarakat. Cotton bud tidak hanya digunakan oleh orang dewasa, tetapi juga digunakan oleh anak-anak. Tujuan: diketahui hubungan penggunaan cotton bud dengan serumen obsturan di RS Pertamina Bintang Amin Bandar Lampung.Metode penelitian: Jenis penelitian kuantitatif, rancangan analitik observasional dengan pendekatan cross sectional. Populasi yaitu 390 orang pasien serumen obsturan yang diambil dari kuisioner di RS Pertamina Bintang Amin Bandar Lampung. Pengambilan data menggunakan kuesioner. Teknik analisis data menggunakan uji statistik Chi-square.Hasil: menunjukkan bahwa dari 390 pasien serumen obsturan sebagian besar penggunaan cotton budnya tidak baik yaitu sebanyak 200 orang (51,3%), sebagian besar penggunaan serumen obsturan menutup lubang yaitu sebanyak 222 orang (56,9%). Ada hubungan penggunaan cotton bud dengan serumen obsturan di RS Pertamina Bintang Amin Bandar Lampung. Kesimpulan: ada hubungan penggunaan cotton bud dengan serumen obsturan di RS Pertamina Bintang Amin Bandar Lampung (p value 0,000, OR 2,459). Disarankan melakukan perawatan telingan dengan tepat sehingga tidak timbul serumen obsturan yang dapat menyebabkan gangguan pendengaran. Kata Kunci : Cotton Bud, Serumen Obsturan

Antioxidant Effect of Curcumin on the Prevention of Oxidative Damage to the Cochlea in an Ototoxic Rat Model Based on Malondialdehyde Expression

Introduction Aminoglycoside, as an antimicrobial medication, also has side-effects on the inner ears, bringing about hearing disorders. Curcumin has been proven to be a strong scavenger against various reactive oxygen species (ROS), and the increase in ROS production is considered to play an important role in the process of hearing disorder. Objective To prove that curcumin is an effective antioxidant to prevent cochlear damage based on malondialdehyde (MDA) expression. Methods The present research used 32 Rattus norvegicus, of the Wistar lineage, randomly divided into 8 groups: negative control, ototoxic control (a single dose of 40 mg/ml of gentamicin via intratympanic injection), 2 groups submitted to ototoxic control + curcumin treatment (100 mg/kg, 200 mg/kg), 2 groups who iunderwent ototoxic control + curcumin treatment for 7 days, and two groups submitted to curcumin treatment as prevention for 3 days + ototoxic induction. Results The results showed that the lowest dosage of curcumin (100 mg/kg) could decrease MDA expression on the cochlear fibroblastic wall of the ototoxic model; however using greater doses of curcumin (200 mg/kg) for 7 days would provide a better effect. Curcumin could also significantly decrease MDA expression when it was administered during the preototoxic exposure. Conclusion Curcumin can be used as a therapy for ototoxic prevention based on the decrease in MDA expression.

Missense variant in LOXHD1 is associated with canine nonsyndromic hearing loss

Hearing loss is a common sensory deficit in both humans and dogs. In canines, the genetic basis is largely unknown, as genetic variants have only been identified for a syndromic form of hearing impairment. We observed a congenital or early-onset sensorineural hearing loss in a Rottweiler litter. Assuming an autosomal recessive inheritance, we used a combined approach of homozygosity mapping and genome sequencing to dissect the genetic background of the disorder. We identified a fully segregating missense variant in LOXHD1, a gene that is known to be essential for cochlear hair cell function and associated with nonsyndromic hearing loss in humans and mice. The canine LOXHD1 variant was specific to the Rottweiler breed in our study cohorts of pure-bred dogs. However, it also was present in some mixed-breed dogs, of which the majority showed Rottweiler ancestry. Low allele frequencies in these populations, 2.6% and 0.04%, indicate a rare variant. To summarize, our study describes the first genetic variant for canine nonsyndromic hearing loss, which is clinically and genetically similar to human LOXHD1-related hearing disorder, and therefore, provides a new large animal model for hearing loss. Equally important, the affected breed will benefit from a genetic test to eradicate this LOXHD1-related hearing disorder from the population.

Missense Variant in LOXHD1 is Associated With Canine Nonsyndromic Hearing Loss

Hearing loss is a common sensory deficit both in humans and dogs. In canines the genetic basis is largely unknown, as genetic variants have only been identified for a syndromic form of hearing impairment. We observed a congenital or early-onset sensorineural hearing loss in a Rottweiler litter. Assuming an autosomal recessive inheritance, we used a combined approach of homozygosity mapping and genome sequencing to dissect the genetic background of the disorder. We identified a fully segregating missense variant in LOXHD1, a gene that is known to be essential for cochlear hair cell function and associated with nonsyndromic hearing loss in humans and mice. The canine LOXHD1 variant was specific to the Rottweiler breed in our study cohorts of pure-bred dogs. However, it also was present in mixed-breed dogs, of which the majority showed Rottweiler ancestry. Low allele frequencies in these populations, 2.6 % and 0.04 %, respectively, indicate a rare variant. To summarize, our study describes the first genetic variant for canine nonsyndromic hearing loss, which is clinically and genetically similar to human LOXHD1-related hearing disorder, and therefore, provides a new large animal model for hearing loss. Equally important, the affected breed will benefit from a genetic test to eradicate the hearing disorder from the population.

Tinnitus: A Tingling Mystery to be Decrypted

Tinnitus is a hearing disorder that causes ringing, buzzing or hissing sensation to the patient’s auditory senses. It has become a very common complaint over the years affecting around 7-8% of the human population all over the world. The disorder causes the patients to feel irritable, annoyed, depressed, and distressed. As a result, it obstructs their sense of relaxation, enjoyment, and even their sleep - thus forcing them to avoid any social gatherings. There has been a substantial amount of work that has been carried out pertinent to this disorder. This paper reviews existing research and work done regarding Tinnitus effects, causes, and diagnosis. The numerous ways in which Tinnitus could affect an individual have been depicted. From the plethora of probable causes of this disorder, the most conceivable ones are highlighted. Moreover, this paper documents and reviews the attempts at treating Tinnitus, relevant engineering breakthroughs, and the various ways in which Tinnitus noise is suppressed – such as Tinnitus Retraining Therapy, Neuromodulation, and Signal processing approach. The manuscripts highlight the pros and cons of these methods. Over 45 research articles and other reliable internet medical sources were reviewed and these pieces of work were contrasted. These findings should help in understanding both – the disorder, as well as the situation of the patients suffering from it. Through this manuscript, an attempt was made to spread awareness about the mysterious disorder.

A Case Report on Familial origin of Auditory Neuropathy Spectrum Disorder

Auditory neuropathy Spectrum Disorder (ANSD) is a unique hearing disorder where outer hair cell status is found to be normal, but inner hair cell and/or the synaptic connections to the auditory nerve is disrupted. It is a diverse group of hearing disorder which can be manifested either congenitally or can be late in onset. However, there are various etiologies of auditory neuropathy which is represented in the literature, which includes birth related risk factors for hearing loss like prematurity, bilirubin synthesis issues, lack of oxygen supply to the baby during or after delivery, and genetic actors. It is estimated that approximately 40% of cases have an underlying causal factor as genetic origin, which can be inherited in either syndromic or non-syndromic way. The below case report provides an extra support for the fundamental genetic trait in ANSD. The study presents two congenital ANSD cases where, both children were diagnosed as congenital ANSD