Mathematical Modeling of Treatment Effect on Tumor Growth and Blood Flow through a Channel with Magnetic Field

In this research, we investigated the effect of tumor growth on blood flow through a micro channel by formulated the governing model with the assumption that blood is an incompressible, eclectrially conducting fluid which flow is caused by the pumping action of the heart and suction. The governing model was scaled using some dimensionless variables and the region of the tumor was obtained from Dominguez [1] which was incorporated in our model. The model is further reduced to an ordinary differential equation using a perturbation condition. However, the ordinary differential equation was solved using method of undermined coefficients, and the constants coefficients obtained via matrix method. Furthermore, the simulation to study the effect of the pertinent parameters was done suing computation software called Mathematica. It is seen in our investigation that the entering parameters such as magnetic field parameter, the Reynolds number, womersley number, oscillatory frequency parameter, and permeability parameter affect the blood velocity profile in decreasing and increasing fashion.

Analytical and numerical study for oscillatory flow of viscoelastic fluid in a tube with isosceles right triangular cross section

A theoretical investigation is carried out to analyze the oscillatory flow of second-grade fluid under the periodic pressure gradient in a long tube of isosceles right triangular cross section in the present study. The analytical expressions for the velocity profile and phase difference are obtained. The numerical solutions are calculated by using the finite difference method with Crank–Nicolson (C–N) scheme. In comparison with the Newtonian fluid (λ = 0), the effects of retardation time, Deborah number and Womersley number on the velocity profile and phase difference are discussed numerically and graphically. For smaller Womersley number, the behavior of second-grade fluid is dominated by viscosity. For larger Womersley number α = 20, the flow becomes more difficult to be generated under periodic pressure gradient with increasing retardation time. Furthermore, the analytical expressions of the mean velocity amplitude and phase difference are given explicitly for discussing.

Structural Analysis of Couette-Taylor Flow With Periodic Oscillation of the Inner Cylinder in Different Flow Regimes

The structures of flow in laminar Couette-Taylor flow with periodic oscillation of the inner cylinder rotation velocity (which linearly increases from zero to a fixed maximum value and then goes to zero again in each period) for different three regimes; Couette flow, Taylor vortex and wavy vortex, with the effect of the Womersley number, Wo, for different periods and the critical Taylor number are investigated numerically. The Wo varies between. 0.38 ≤ Wo ≤ 8.59. To understand how the flow responds to a given boundary conditions, the critical Taylor number is calculated and the structure of vortices which formed in the flow field is investigated. The results show that if Wo is increased, i.e. when the slope of rotational velocity of inner cylinder is increased, more delay in changing the flow regime compare to the steady state (when the inner cylinder rotates with constant velocity) is observed. Also for large values of Wo, due to the inertia, the flow does not follow the given boundary condition so for the higher value of the Womersley number, Wo = 8.59, there is a time lag and vortices do not appear until the second period of the inner cylinder oscillations. The reason is that the time scale of the dynamics of flow is less than the time scale that is associated with the flow instability, thus the flow regime behaves like a laminar Couette flow at the initial period. Comparing the present results with that of steady state, it is appeared that for a minimum value of Wo used in this paper, i.e. Wo = 0.38, the primary critical Taylor number is 50% higher than that of steady state.

Simplified Transition and Turbulence Modeling for Oscillatory Pipe Flows

One-dimensional unsteady Reynolds-averaged Navier–Stokes computations were performed for oscillatory transitional and turbulent pipe flows and the results were validated against existing experimental data for a wide variety of oscillatory Reynolds and Womersley numbers. An unsteady version of the Johnson–King model was implemented with optional near-wall modification to account for temporal pressure gradient variations, and the predictions were compared with those of the Spalart–Allmaras and k–ε turbulence models. Transition and relaminarization were based on empirical Womersley number correlations and assumed to occur instantaneously: in the former case, this assumption was valid, but in the latter case, deviations between data and predictions were observed. In flows where the oscillatory Reynolds numbers are substantially higher than the commonly accepted steady critical value (~2000), fully or continuously turbulent models produced the best correspondence with experimental data. Critically and conditionally turbulent models produced slightly inferior correspondence, and no significant benefit was observed when near-wall pressure gradient effects were implemented or when common one- and two-equation turbulence models were employed. The turbulent velocity profiles were mainly unaffected by the oscillations and this was explained by noting that the turbulent viscosity is significantly higher than its laminar counterpart. Thus, a turbulent Womersley number was proposed for the analysis and categorization of oscillatory pipe flows.

Uncertainty quantification reveals the physical constraints on pumping by peristaltic hearts

Most biological functional systems are complex, and this complexity is a fundamental driver of diversity. Because input parameters interact in complex ways, a holistic understanding of functional systems is key to understanding how natural selection produces diversity. We present uncertainty quantification (UQ) as a quantitative analysis tool on computational models to study the interplay of complex systems and diversity. We investigate peristaltic pumping in a racetrack circulatory system using a computational model and analyse the impact of three input parameters (Womersley number, compression frequency, compression ratio) on flow and the energetic costs of circulation. We employed two models of peristalsis (one that allows elastic interactions between the heart tube and fluid and one that does not), to investigate the role of elastic interactions on model output. A computationally cheaper surrogate of the input parameter space was created with generalized polynomial chaos expansion to save computational resources. Sobol indices were then calculated based on the generalized polynomial chaos expansion and model output. We found that all flow metrics were highly sensitive to changes in compression ratio and insensitive to Womersley number and compression frequency, consistent across models of peristalsis. Elastic interactions changed the patterns of parameter sensitivity for energetic costs between the two models, revealing that elastic interactions are probably a key physical metric of peristalsis. The UQ analysis created two hypotheses regarding diversity: favouring high flow rates (where compression ratio is large and highly conserved) and minimizing energetic costs (which avoids combinations of high compression ratios, high frequencies and low Womersley numbers).

Diversion of Pulsatile Flow Over a Rectangular Sidewall Cavity Using Superhydrophobic Mesh

Pulsatile flow over open cavity represents one type of physiological phenomenon related to a few common cardiovascular diseases, such as cerebral sidewall aneurysm and arrhythmia-induced thromboembolism in the left atrium appendage (LAA). In recent years, endovascular treatments using mesh-based implants have become increasingly popular. In this paper, we study the characteristics of pulsatile flow over a simplified sidewall cavity under two Reynolds/Womersley number conditions using Particle Image Velocimetry. The impacts of a regular mesh and a superhydrobobically-coated mesh on the cavity flow are investigated. Our results quantify the phase-to-phase changes of the flow fields and reveal the formation and the transport of the primary vortex over the ostium of the rectangular cavity. Results suggest the meshes diverted the main flow away from the cavity and prohibited the development of the primary vortex. A penetrated jet flow was formed near the front side of the cavity due to the presence of the mesh. The superhydrophobic mesh dramatically reduced the kinetic energy of the penetrated jet into the cavity. It indicates the mesh flow diversion is effective because of the destruction of the shear-induced vortex dynamics that causes flow stagnation on the rear cavity wall. Our results also indicate the superhydrophobic coating is potentially beneficial in terms of reducing the hemodynamic loading inside the cavity.

Oscillatory Carreau flows in straight channels

The present paper studies the oscillatory flow of Carreau fluid in a channel at different Womersley and Carreau numbers. At high and low Womersley numbers, asymptotic expansions in small parameters, connected with the Womersley number, are developed. For the intermediate Womersley numbers, theoretical bounds for the velocity solution and its gradient, depending on the problem parameters, are proven and explicitly given. It is shown that the Carreau number changes the type of the flow velocity to be closer to the Newtonian velocity corresponding to low or high shear or to have a transitional character between both Newtonian velocities. Some numerical examples for the velocity at different Carreau and Womersley numbers are presented for illustration with respect to the similar Newtonian flow velocity.

Numerical Characterization of Viscous Heat Dissipation Rate in Oscillatory Air Flow

The effect of viscous heat dissipation (VHD) in raising the temperature field of incompressible oscillatory air flow is studied numerically. A threshold is established for when the viscous heat dissipation term in the thermal energy equation changes or does not change the temperature field for the case of oscillatory air flow in a tube connecting two reservoirs. This new criterion has not been specified clearly in earlier oscillatory flow research. According to the defined threshold and when VHD is important, the effect of dissipative bulk heating can be described by a proposed correlation in terms of Womersley number (Wo) and axial tidal displacement (ΔZ) of the oscillatory fluid. These results are determined using two-dimensional (2D) numerical simulations of laminar oscillatory air flow (Pr = 0.7) for different adiabatic unconductive tube-reservoirs' systems configurations over a wide range of oscillatory frequencies and tidal displacements. It is found that the low amount of fluid kinetic energy, which is converted into internal energy, is not sufficient to significantly heat up the fluid at a low rate of the viscous work. Therefore, the effect of viscous heat dissipation in oscillatory air flow can be ignored only below a specific limit of unsteadiness depending on Womersley number and axial tidal displacement. Also, the results showed that the VHD becomes more significant with increasing (Wo) and (ΔZ).