Physical realization of complex dynamical pattern formation in magnetic active feedback rings

We report the clean experimental realization of cubic-quintic complex Ginzburg-Landau physics in a single driven, damped system. Four numerically predicted categories of complex dynamical behavior and pattern formation are identified for bright and dark solitary waves propagating around an active magnetic thin film-based feedback ring: (1) periodic breathing; (2) complex recurrence; (3) spontaneous spatial shifting; and (4) intermittency. These nontransient, long lifetime behaviors are observed in self-generated microwave spin wave envelopes circulating within a dispersive, nonlinear yttrium iron garnet waveguide. The waveguide is operated in a ring geometry in which the net losses are directly compensated for via linear amplification on each round trip (of the order of 100~ns). These behaviors exhibit periods ranging from tens to thousands of round trip times (of the order of $\mu$s) and are stable for 1000s of periods (of the order of~ms). We present 10 observations of these dynamical behaviors which span the experimentally accessible ranges of attractive cubic nonlinearity, dispersion, and external field strength that support the self-generation of backward volume spin waves in a four-wave-mixing dominant regime. Three-wave splitting is not explicitly forbidden and is treated as an additional source of nonlinear losses. All observed behaviors are robust over wide parameter regimes, making them promising for technological applications. We present ten experimental observations which span all categories of dynamical behavior previously theoretically predicted to be observable. This represents a complete experimental verification of the cubic-quintic complex Ginzburg-Landau equation as a model for the study of fundamental, complex nonlinear dynamics for driven, damped waves evolving in nonlinear, dispersive systems. The reported dynamical pattern formation of self-generated dark solitary waves in attractive nonlinearity without external sources or potentials, however, is entirely novel and is presented for both the periodic breather and complex recurrence behaviors.

Differential Dynamical Pattern of Regional Homogeneity in Bipolar and Unipolar Depression: A Preliminary Resting-State fMRI Study

Background: Bipolar depression (BD) and unipolar depression (UD) are both characterized by depressive moods, which are difficult to distinguish in clinical practice. Human brain activity is time-varying and dynamic. Investigating dynamical pattern alterations of depressed brains can provide deep insights into the pathophysiological features of depression. This study aimed to explore similar and different abnormal dynamic patterns between BD and UD.Methods: Brain resting-state functional magnetic resonance imaging data were acquired from 36 patients with BD type I (BD-I), 38 patients with UD, and 42 healthy controls (HCs). Analysis of covariance was adopted to examine the differential pattern of the dynamical regional homogeneity (dReHo) temporal variability across 3 groups, with gender, age, and education level as covariates. Post-hoc analyses were employed to obtain the different dynamic characteristics between any 2 groups. We further applied the machine-learning methods to classify BD-I from UD by using the detected distinct dReHo pattern.Results: Compared with patients with UD, patients with BD-I demonstrated decreased dReHo variability in the right postcentral gyrus and right parahippocampal gyrus. By using the dReHo variability pattern of these two regions as features, we achieved the 91.89% accuracy and 0.92 area under curve in classifying BD-I from UD. Relative to HCs, patients with UD showed increased dReHo variability in the right postcentral gyrus, while there were no dReHo variability differences in patients with BD-I.Conclusions: The results of this study mainly report the differential dynamic pattern of the regional activity between BD-I and UD, particular in the mesolimbic system, and show its promising potential in assisting the diagnosis of these two depression groups.

Parameters of temperature disturbance triggering the propagation of the quench front on an extremely overheated surface

The results of computational experiments simulating the triggering of the quench front propagation on the superheated vertically oriented metal plates are presented. The plates are quenched by a gravitationally flowing down liquid nitrogen film. The temperature of the test samples at the beginning of the process was higher than the critical temperature and the Leidenfrost temperature, which means that direct long-term liquid-solid contact is impossible. For this reason, the front is initially motionless. As a result of numerical simulation, a dynamic pattern of the quench front propagation on a high-temperature surface was obtained. Analysis of the results allowed to find the realistic values of heat sink into the cooling medium, as well as the parameters of the local temperature disturbance, its spatial extent and amplitude, at which the conditions are created for triggering the process of quench front propagation on the high-temperature surface. Direct comparison of the numerical simulations results with experimental data on the velocity, geometry of the quench front and on the dynamical pattern of the process confirmed the reliability of the results obtained.

Dynamical Characteristics of Drought in the Caribbean from Observations and Simulations

Climate models consistently project a significant drying in the Caribbean during climate change, and between 2013 and 2016 the region experienced the worst multiyear drought in the historical period. Although dynamical mechanisms have been proposed to explain drought in the Caribbean, the contributions from mass convergence and advection to precipitation minus evaporation (P − E) anomalies during drought are unknown. Here we analyze the dynamics of contemporaneous droughts in the Caribbean by decomposing the contributions of mass convergence and advection to P − E using observational and simulated data. We find that droughts arise from an anomalous subsidence over the southeastern Caribbean and northeastern South America. Although the contributions from mass convergence and advection vary across the region, it is mass convergence that is the main driver of drought in our study area. A similar dynamical pattern is observed in simulated droughts using the Community Earth System Model (CESM) Large Ensemble (LENS).

ANALYSIS OF EFFICIENCY OF THE TEMPORO-MANDIBULAR DISORDERS TREATMENT

Relevance. Treatment of the temporo-mandibular joint (TMJ) dysfunctions still stays an urgent issue of modern stomatology. Its significance is predisposed for its high incidence and annual increase in patients’ referrals as well as diversity of it clinical manifestations, complexity of diagnosis and treatment, variability of clinical pattern, which requires a multi-disciplinary approach. According to Ukrainian and foreign authors, the TMJ pathologies take up the third place after caries and parodontal diseases, being diagnosed in 20 % of children and almost 87 % of adults. The share of patients with the TMJ dysfunction increases every year. The 79 % are represented with the intra-capsular disorders of the temporo-mandibular joints. The study was necessitated by the fact that there is still no single agreement in the treatment methods and definite treatment protocols regarding the intracapsular TMJ disorders. Objectives: analysis of efficiency of the TMJ intracapsular disorders patients’ treatment using the pathogenetically rationalized conservative and mini-invasive surgical methods. Methods and materials. The study includes the data of 38 patients with complaints of the TMJ region pain and the TMJ dysfunction. All patients were examined according to the common protocol. According to the disorder stage, the patients were administered either the conservative treatment course using the treatment tray on the mandible or maxilla, with the subsequent orthopedic or prosthetic treatment, or the splint therapy with subsequent surgical intervention. Results. Having analyzed the dynamical pattern of the treatment outcomes within the study, it has been detected that the surgical injection correction of the TMJ disorders was effective in all examined patients. To provide for the long-term steady treatment outcome the prosthetic-orthopedic rehabilitation measures were indicated, aimed at preserving the correct occlusion relation. Conclusion. The method of hyaluronic acid preparations injection into the TMJ cavity as a stage of the TMJ dysfunction therapy has proven its effectiveness in all the examined patients. In order to achieve the long-term steady result, the patients were recommended prosthetic-orthopedic rehabilitation for producing and supporting the occlusion relation.

GAG positioning on IL-1RI; A mechanism regulated by dual effect of glycosylation

IL-1RI is the signaling receptor for the IL-1 family of cytokines that are involved in establishment of the innate and acquired immune systems. Glycosylated extracellular (EC) domain of the IL-1RI binds to agonist such as IL-1β or antagonist ligands and the accessory protein to form the functional signaling complex. Dynamics and ligand binding of the IL-1RI is influenced by presence of the glycosaminoglycans (GAGs) of the EC matrix. Here a combination of molecular dockings and molecular dynamics simulations of the unglycosylated, partially N-glycosylated and fully N-glycosylated IL-1RI EC domain in the apo, GAG-bound and IL-1β-bound states were carried out to explain the co-occurring dynamical effect of receptor’s glycosylation and GAGs. It was shown that the IL-1RI adopts two types of “extended” and “locked” conformations in its dynamical pattern, and glycosylation maintains the receptor in the latter form. Maintaining the receptor in the locked conformation disfavors IL-1β binding by burying its two binding site on the IL-1RI EC domain. Glycosylation disfavors GAG binding to the extended IL-1RI EC domain by sterically limiting the GAGs degrees of freedom in targeting its binding site, while it favors GAG binding to the locked IL-1RI by favorable packing interactions.