Chapter 16 addresses several common chronic pain-associated conditions. Utilizing the comprehensive, multimodal, evidence-based approach to assisting patients in planning for pain self-management, the chapter describes common chronic pain-associated conditions, including those of the head, such as chronic tension headache, temporomandibular joint disorder, and chronic migraine; the spine, such as chronic neck and low back pain; the appendicular musculoskeletal system, such as hip, knee, and shoulder pain; common neuropathic pain conditions, such as diabetic peripheral neuropathy; and common compressive neuropathies, such as carpal tunnel syndrome and ulnar neuropathy. The conditions are presented in terms of common characteristics, pathophysiologic features, and the basic approach to treatment.