QOLP-23. EVALUATION OF FINANCIAL TOXICITY (FT) IN PEOPLE WITH RARE CENTRAL NERVOUS SYSTEM (CNS) TUMORS USING AN INNOVATIVE WEB-BASED STUDY DESIGN

BACKGROUND Financial toxicity (FT) refers to the negative financial impact of cancer. Research exploring FT in patients with CNS tumors is limited to more common diagnoses or within single institutions. Total income, work interference and symptom burden are all key parameters when investigating FT in patients with rare CNS tumors. METHODS A web-based study of 210 participants’ responses to financial, clinical, symptom burden (MDASI-BT/MDASI-SP), depression and anxiety (PROMIS-Depression/Anxiety), work interference (SF-36) and general health status (EQ-5D-3L) is reported using descriptive statistics and tests of associations. RESULTS Patients were white (93%) employed (48%) females (72%), with median age of 47 (19-75). The most common diagnosis was ependymoma (80%). Original tumor location was the brain in 83 (40%) and spine in 115 (55%). Median time from tissue diagnosis was 48 months (0 – 402). Income was lower than the poverty level in 6% and lower than the median U.S. in 23%. A change in work due to their tumor was reported by 60%, with the majority stopping work (31%). One-third reported lack of access to health-care services and 10% required home care services. Difficulty walking was reported by 42% and difficulty in performing activities due to physical health by over 60%. Anxiety and depression scores aligned with the average for the U.S. population; however, 21% were taking antidepressants and 42% reported not being able to complete work or activities due to depression. Half of all patients reported moderate-severe pain, fatigue, and weakness with higher symptom burden and depression associated with change in work status (p < 0.003). CONCLUSION Patients with rare CNS tumors report an impact of their tumor diagnosis on activities/work patterns, with an associated higher symptom burden. Future studies exploring financial impact in patients with rare CNS tumors and targeted programs to address these outcomes are needed.

Can prebiotic reaction systems survive in the wild? An interference chemistry approach

The origin of life occurred by a series of prebiotic reaction pathways (collectively a system) hosted in one or more geochemical environments (together forming an origin of life scenario). State-of-the-art prebiotic chemistry links together reactions to create systems, intended to be more representative of the diverse chemical pathways that may have proceeded on early Earth. By practical necessity, prebiotic systems chemistry must be investigated under simplified conditions in comparison to likely natural environments. The mismatch in complexity between lab and environment poses a challenge: how to build systems chemistry that is robust not only in the idealised conditions of a lab, but also under natural levels of environmental stress? Here, we propose and formalise a conceptual framework for such work: interference chemistry. We define interference chemistry as the interaction between prebiotic systems chemistry and the environmental scenarios proposed to host it. Natural environments in which prebiotic chemistry could have occurred are messy, containing many spectator ions, mineral phases, and spatially and temporally variable physical processes, e.g., wet/dry cycles. Each of these environmental variables may interfere either constructively or destructively with prebiotic pathways, respectively aiding or inhibiting their efficacy. Exploring interference chemistry for a reaction system will point towards favoured or disfavoured regions of environmental parameter space. To do so, innovation is needed in both the investigation of early planetary environmental conditions, and the continued incorporation of these constraints into experimental systems chemistry. We argue that interference chemistry provides a compelling way to assess combinations of system and environment, leading the way to increasingly prebiotically plausible scenarios for the origin of life on Earth.

Work interference with family and turnover intentions in Pakistani banks: the role of psychological breach

The purpose of this study was to explore the relationship between work-family interference (WIF), organizational and occupational turnover intentions. Further, it was investigated if the relationships are mediated by ‘psychological contract breach’ (PCB) concerning ‘work-family balance obligations’. A study was completed by gathering data using a self-administered survey from employees working in the Pakistani Banking industry (n=359). The results indicate that WIF is positively linked to organizational and occupational turnover intentions. Results of mediation analyses showed a significant indirect effect of WIF, via PCB, on occupational turnover intentions but not on organizational turnover intentions. This study provides insight into the mechanisms through which WIF affects employee turnover intentions. Moreover, this study adds to psychological contract theory by revealing insight into the particular sub of work-family content of work-family balance obligations.

Mitigating work interference with family by leveraging an entrepreneurial strategic posture

This article adds to entrepreneurship research by detailing the mediating role of work-related emotional exhaustion in the connection between the extent to which women entrepreneurs experience work interference with family—defined as the degree to which the quality of their personal lives is compromised by work demands—and the performance of their businesses. It also predicts a buffering role of the entrepreneurial strategic posture of their businesses in this process. Survey data collected among women entrepreneurs in Chile indicate that the depletion of entrepreneurs’ work-related energy resource reservoirs is an important reason that increasing levels of work interference with family diminish business performance. This mediating role of emotional exhaustion is less prominent when they run their businesses entrepreneurially, which might help them find innovative solutions for the negative spillovers of work stress into the family domain. This research therefore reveals a critical challenge for women entrepreneurs who suffer in their personal lives due to pressing work demands: the associated emotional drainage compromises the success of their business endeavors, which eventually can generate even more hardships. This study also shows how women entrepreneurs can address this challenge, that is, by drawing from the novel insights that arise from an entrepreneurial strategic posture.

Komitmen Kerja, Lingkungan Kerja Nonfisik, dan Work Interference With Family terhadap Kinerja Pegawai pada Badan Kepegawaian dan Pengembangan Sumber Daya Manusia

Banyak pegawai yang masih menjaga jarak dan membanding-bandingkan satu sama lain, sehingga lingkungan kerja menjadi tidak terjalin dengan harmonis. Terkadang pegawai menjaga jarak dengan atasannya karena merasa takut dengan gaya kepemimpinan atasannya yang keras dan komunikasi bawahan dengan atasan tidak terjalin baik. Tujuan penelitian ini adalah untuk menganalisis pengaruh secara parsial atau simultan komitmen kerja, lingkungan kerja nonfisik dan work nterferece with family terhadap kinerja pegawai pada Badan Kepegawaian dan Pengembangan Sumber Daya Manusia. Model penelitian yang digunakan adalah metode penelitian kuantitatif. Populasi dalam penelitian ini berjumlah 68 orang. Teknik sampling adalah probability sampling dengan sebanyak 67 orang responden. Data dianalisis dengan menggunakan uji asumsi klasik, analisis regresi linier berganda, analisis determinasi, uji signifikansi simultan (F-test) dan uji signifikansi parsial (t-test). Hasil penelitian menunjukkan nilai f-hitung 5,682 > dari nilai f-tabel 1,518 dan f-hitung dengan nilai signifikansi 0,002 yang menunjukkan bahwa variabelkomitmen kerja, lingkungan kerja nonfisik dan work interference with family berpengaruh positif dan signifikan terhadap kinerja pegawai pada Badan Kepegawaian Dan Pengembangan Sumber Daya Manusia. Implikasi penelitian ini dapat memberikan evaluasi dalam meningkatkan kinerja karyawan.

PENGARUH KONFLIK PEKERJAAN KELUARGA TERHADAP KINERJA PERAWAT DIMEDIASI STRES KERJA PADA RUMAH SAKIT JIWA PROVINSI NTB

Konflik pekerjaan keluarga terjadi ketika ada ketidakseimbangan antara peran seorang individu dalam pekerjaan dan keluarga yang membuat partisipasi penuh dalam kedua peran tersebut menjadi lebih sulit. Umumnya, setiap individu dengan berbagai jenis profesinya rentan terhadap konflik ini. Masalah ini sangat kompleks dan menyeimbangkan keduanya terasa sangat rumit, terutama dalam tekanan tinggi dan untuk profesi yang menuntut intensitas tinggi seperti perawat yang merawat pasien penyakit jiwa. Penelitian ini bertujuan untuk menganalisis pengaruh komponen konflik pekerjaan keluarga yaitu work interference with family (WIF) dan family interference with work (FIW) terhadap stres kerja dan kinerja perawat dalam merawat pasien gangguan jiwa. Kuisioner dibagikan kepada 53 perawat wanita yang sudah menikah yang bekerja di Rumah Sakit Jiwa Mutiara Sukma Provinsi Nusa Tenggara Barat dan data dianalisis menggunakan Partial Least Square (PLS). Hasil temuan menunjukkan bahwa komponen konflik pekerjaan keluarga; WIF dan FIW berpengaruh positif dan signifikan terhadap tingkat stres kerja, dan berpengaruh negatif dan signifikan terhadap prestasi kerja perawat. Secara spesifik, studi ini membuktikan bahwa satu-satunya komponen yang berpengaruh negatif terhadap kinerja adalah FIW. Hal ini juga menunjukkan bahwa stres kerja berpengaruh negatif dan signifikan terhadap kinerja perawat.

A Crossover Design for Comparative Efficacy: A 28 Days-Randomized Clinical Trial of Cognitive Behavioral Therapy for Chronic Pain of Degenerative Conditions

In physiotherapy practice, a number of patients are known to suffer from chronic pain which results in reduced activity levels, interference in sleep, enjoyment of life, mood, and relations with others. Cognitive behavioral therapy, in this aspect will provide a holistic approach to the available treatment. Cognitive behavioral therapy has also been shown to target cognitive distortions such as pain catastrophizing, fear avoidance, overgeneralizing and others, all the while improving physical health, activity levels and quality of life. This study assessed the efficacy of cognitive behavioral therapy in the management of patients with chronic pain at the University Teaching Hospitals in Zambia. A randomized clinical trial utilizing a crossover design was utilized for the study. A random sample of 32 participants was used in the study after fulfilling the study criteria. Data was analyzed using ANCOVA with alpha of 0.05. The study recorded small effects in the reduction of pain intensity in both phase one and two. In phase one, it also recorded small effects in general work interference, sleep interference and enjoyment of life interference but recorded medium effects in normal work interference and mood interference. Phase two of the study recorded small effect size in reduction of general work interference, normal work interference, mood interference, relations with others interference, sleep interference and Enjoyment of Life interference. Cognitive behavioral therapy ensures the management of chronic pain addresses areas in which an individual is affected by pain and which in turn exacerbate the chronic pain. Physiotherapy provides a more holistic approach when used in conjunction with cognitive behavioral therapy.

Work-Family Conflict and Job Performance: Moderating Effect of Social Support among Employees in Malaysian Service Sector

This study aims to examine the relationship between work-family conflict (work interference family and family interference work) and job performance among employees in Malaysian service sector. In addition, this study focuses on exploring the moderating effect of social support received from supervisors and family members on the relationship of work-family conflict dimensions with employee’s job performance. This study is employed quantitative method whereby the questionnaires are used to gather the data.The data for the present study were collected from a total of 250 employees working in Malaysian service sector.The mean, standard deviations, correlations, and moderated hierarchical regression analysis were performed in analyzing the data by using the IBM SPSS statistics software 23. The results of the study indicate that work interference family and family interference work are negatively correlated with employee’s job performance. Moreover, social support received from supervisors and family members is observed to significantly moderate the relationship of work interference family and family interference work with employee’s job performance.

Flexible Work Arrangements and Work-Family Conflict: A Systematic Literature Review

The spread of the Covid-19 pandemic has essentially led to the closure of many businesses worldwide. With the increasing number of viruses in every part of the world, there is a need for flexible work arrangements to maintain the operations. Somehow, managing workloads using these arrangements have also affected work-family conflict during a pandemic situation. Plus, there is a dearth in the literature of flexible work arrangements in the context of work-family conflict. Thus, the purposes of this review are to investigate how these factors are related to work interference with family (WIF), and family-interference with work (FIW), and its outcomes, such as work-life balance, well-being, mental health, turnover intentions, satisfaction, and others. The reviewed articles were obtained from three main databases; Web of Science, Scopus, and Science Direct from the year 2000 until 2020. Keywords including "flexibility work arrangement," "flexible," "work arrangement," “schedule flexibility,” “work hours,” “schedule,” "work-family conflict,” “family-work conflict,” “work interference with family” and “family interference with work” were managed to identify 31 articles. Also, this systematic review was conducted to collect the findings on the relationship of the above domains, which can be used by businesses to adapt to the new normal. Several recommendations were proposed to conduct further study, especially in research design, method, and measurements.