Human Adenovirus Species D Interactions with Corneal Stromal Cells

Notable among the many communicable agents known to infect the human cornea is the human adenovirus, with less than ten adenoviruses having corneal tropism out of more than 100 known types. The syndrome of epidemic keratoconjunctivitis (EKC), caused principally by human adenovirus, presents acutely with epithelial keratitis, and later with stromal keratitis that can be chronic and recurrent. In this review, we discuss the current state of knowledge regarding the molecular biology of adenovirus infection of corneal stromal cells, among which the fibroblast-like keratocyte is the most predominant, in order to elucidate basic pathophysiologic mechanisms of stromal keratitis in the human patient with EKC.

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Linked Data in a Nutshell: A Starter Kit of Selected Annotated Bibliography and Resources for Academic Librarians: Part One

International Journal of Librarianship ◽

10.23974/ijol.2018.vol3.1.47 ◽

2018 ◽

Vol 3 (1) ◽

pp. 36

Author(s):

Weiling Liu

Keyword(s):

Information Retrieval ◽

Case Studies ◽

Linked Data ◽

Annotated Bibliography ◽

Academic Librarians ◽

English Only ◽

Current State ◽

The Many ◽

Data Evolution ◽

The Web

It has been a decade since Tim Berners-Lee coined Linked Data in 2006. More and more Linked Data datasets have been made available for information retrieval on the Web. It is essential for librarians, especially academic librarians, to keep up with the state of Linked Data. There is so much information about Linked Data that one may wonder where to begin when they want to join the Linked Data community. With this in mind, the author compiled this annotated bibliography as a starter kit. Due to the many resources available, this list focuses on literature in English only and of specific projects, case studies, research studies, and tools that may be helpful to academic librarians, in addition to the overview of Linked Data concept and the current state of Linked Data evolution and adoption.

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The effect of prior long-term recellularization with keratocytes of decellularized porcine corneas implanted in a rabbit anterior lamellar keratoplasty model

10.1101/2020.12.31.424936 ◽

2020 ◽

Author(s):

Julia Fernández-Pérez ◽

Peter W. Madden ◽

Robert Thomas Brady ◽

Peter F. Nowlan ◽

Mark Ahearne

Keyword(s):

Stromal Cells ◽

Scar Tissue ◽

Dendritic Morphology ◽

Lamellar Keratoplasty ◽

Human Cornea ◽

Serum Free ◽

Anterior Lamellar Keratoplasty ◽

Potential Alternative

AbstractDecellularized porcine corneal scaffolds are a potential alternative to human cornea for keratoplasty. Although clinical trials have reported promising results, there can be corneal haze or scar tissue. Here, we examined if recellularizing the scaffolds with human keratocytes would result in a better outcome. Scaffolds were prepared that retained little DNA (14.89 ± 5.56 ng/mg) and demonstrated a lack of cytotoxicity by in vitro. The scaffolds were recellularized using human corneal stromal cells and cultured for between 14 in serum-supplemented media followed by a further 14 days in either serum free or serum-supplemented media. All groups showed full-depth cell penetration after 14 days. When serum was present, staining for ALDH3A1 remained weak but after serum-free culture, staining was brighter and the keratocytes adopted a native dendritic morphology with an increase (p < 0.05) of keratocan, decorin, lumican and CD34 gene expression. A rabbit anterior lamellar keratoplasty model was used to compare implanting a 250 µm thick decellularized lenticule against one that had been recellularized with human stromal cells. In both groups, host rabbit epithelium covered the implants, but transparency was not restored after 3 months. Post-mortem histology showed under the epithelium, a less-compact collagen layer, which appeared to be a regenerating zone with some α-SMA staining, indicating fibrotic cells. In the posterior scaffold, ALDH1A1 staining was present in all the acellular scaffold, but in only one of the recellularized lenticules. We conclude that recellularization with keratocytes alone may not be sufficiently beneficial to justify introducing allogeneic cells without concurrent treatment to further manage keratocyte phenotype.

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Is Down Syndrome Doomed? How State Statutes Can Help Expectant Parents Make Informed Decisions about Prenatal Down Syndrome Diagnoses*

Pittsburgh Journal of Environmental and Public Health Law ◽

10.5195/pjephl.2012.33 ◽

2012 ◽

Vol 6 (2) ◽

Author(s):

Teresa Santin

Keyword(s):

Down Syndrome ◽

First Amendment ◽

Healthcare Providers ◽

Current State ◽

Comprehensive Information ◽

State Statutes ◽

Syndrome Diagnosis ◽

Expectant Mothers ◽

Federal Laws ◽

The Many

Giving birth to a child with Down syndrome is a choice and one that should be well-informed. It has become a trend for expectant parents to abort fetuses with Down syndrome before fully weighing their options.[1] Expectant parents may automatically assume that an individual with Down syndrome will not lead a worthwhile life and that raising the child will pose too many challenges for them.[2] In order to minimize the number of fetuses with Down syndrome that are being aborted (which may be greater than 90%),[3] expectant parents need access to up-to-date, comprehensive information about all aspects of raising a child with Down syndrome, including the many positive aspects. Whatever decision a parent makes regarding raising a child with Giving birth to a child with Down syndrome is a choice and one that should be well-informed. It has become a trend for expectant parents to abort fetuses with Down syndrome before fully weighing their options.[1] Expectant parents may automatically assume that an individual with Down syndrome will not lead a worthwhile life and that raising the child will pose too many challenges for them.[2] In order to minimize the number of fetuses with Down syndrome that are being aborted (which may be greater than 90%),[3] expectant parents need access to up-to-date, comprehensive information about all aspects of raising a child with Down syndrome, including the many positive aspects. Whatever decision a parent makes regarding raising a child with consent. Part IV examines current state and federal laws that require healthcare providers to give information to expectant mothers who receive a prenatal Down syndrome diagnosis. Part IV also addresses why a law requiring post-Down syndrome diagnosis information is not unduly burdensome. Specifically, Part IV looks closely at the Prenatally and Postnatally Diagnosed Conditions Awareness Act and state statutes in Missouri, New Jersey, Alabama, and Virginia. Part V discusses why laws already enacted on this issue are inadequate and proposes a model statute that all states can follow in crafting their own similar laws. Finally, Part V addresses potential concerns related to the proposed law like cost, enforcement, and First Amendment rights, and how those issues may be resolved.

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Environmental Sustainability in New Zealand Museums: A Case Study of Te Manawa Museum, Gallery and Science Centre

10.26686/wgtn.17003338 ◽

2021 ◽

Author(s):

◽

Nina Helen Finigan

Keyword(s):

New Zealand ◽

Environmental Sustainability ◽

Local Context ◽

Bottom Line ◽

Staff Members ◽

Current State ◽

Science Centre ◽

The Status ◽

The Many

<p>Environmental sustainability is becoming an increasingly essential component of modern life. The contemporary museums’ role as public educators, and as guardians of tangible and intangible culture, places them in a unique position to address the various issues surrounding environmental sustainability, from climate change, to bio-diversity loss, to conservation. There is increasing momentum behind the idea that museums should not only engage with environmental sustainability, but that they indeed have a responsibility to. Although museums throughout New Zealand are addressing environmental sustainability, there is currently no thorough examination of how they are doing this. Therefore, the aim of this dissertation was so find out the current state of environmental sustainability in New Zealand museums, and specifically how staff are approaching it. Through engaging in a case study of Te Manawa Museum, Gallery and Science Centre, Palmerston North, and specifically the environmentally themed exhibition Te Awa/The River: Heart of the Manawatu, this dissertation analyses and discusses the realities of addressing institutional environmental sustainability. While the previous literature surrounding this topic has addressed the many reasons why museums should engage with environmental sustainability, this dissertation has expanded on this by analysing and discussing the realities of addressing environmental sustainability from a staff perspective. Through interviews with five Te Manawa staff members, this dissertation has revealed that while museum professionals agree that engagement with environmental sustainability should become part of bottom line holistic sustainable development, the status of museums as trusted democratic institutions can place them in a conflicted space ‘in-between’ when dealing with polarising issues such as the environment. This is particularly relevant to the discussion around new-museological theory, and the importance of local context and reflexive community engagement, where the community essentially help drive museological direction and content.</p>

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Sustainable development

Structural Survey ◽

10.1108/ss-02-2014-0010 ◽

2014 ◽

Vol 32 (4) ◽

pp. 315-330 ◽

Cited By ~ 4

Author(s):

Michelle C. Brennan ◽

Alison J. Cotgrave

Keyword(s):

Sustainable Development ◽

Construction Industry ◽

Positive Impact ◽

Successful Implementation ◽

Content Type ◽

Current State ◽

The Status ◽

The Many ◽

The Uk ◽

Industry Professionals

Purpose – Despite the surge of interest in construction sustainability and the many Government initiatives encouraging reform in the UK construction industry (CI), the prevalence of sustainable development (SD) in the industry is still largely lagging behind that of other industries. Given the amount of focus and activity identified nationally in this area, the purpose of this paper is to investigate the reasons why this is not being translated into action and to seek counsel from industry professionals as to how they believe change can be achieved with a particular focus on how they believe higher education institutions (HEIs) can contribute. Design/methodology/approach – An explorative, qualitative study using three focus groups was of construction professionals. Findings – Despite a lack of action, many in industry support sustainability and actively attempt to engage in sustainable practices but a number of barriers preclude successful implementation. Government initiatives are having a positive impact, with participants believing that both Government and HEIs are imperative in driving the sustainability agenda forward. Research limitations/implications – Whilst limited in scale, this paper highlights the current state of the CI in relation to SD and evidences that progress is being made albeit slowly. The findings may help both Government and HEIs alongside industry in achieving how this can be overcome. Originality/value – Previous research in this area has generally adopted a quantitative approach. Adopting a qualitative approach provides a more in depth view as to why the status quo remains with regards to SD in the CI.

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Introduction

A new naval history ◽

10.7228/manchester/9781526113801.003.0001 ◽

2019 ◽

pp. 1-26

Author(s):

Quintin Colville ◽

James Davey

Keyword(s):

Eighteenth Century ◽

Political Influences ◽

The Past ◽

Current State ◽

Naval History ◽

The Subject ◽

Early Eighteenth Century ◽

The Many ◽

Historical Profession

This introduction gives on overview of the sub-discipline of naval history since its emergence in the early eighteenth-century. It outlines the various social, cultural and political influences that have shaped the subject over the past three centuries, and discusses its relationship with the wider historical profession. The second half of the introduction sums up the current state of naval history, describing the many historiographies that now have a bearing on how the subject is conducted. Each contribution to the volume is introduced in this context, offering a precis of the chapters that follow.

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Epilogue

Changing the Game ◽

10.5810/kentucky/9780813179551.003.0015 ◽

2020 ◽

pp. 219-232

Author(s):

Jim Host ◽

Eric A. Moyen

Keyword(s):

Research University ◽

Student Athletes ◽

Governance Structure ◽

University Of Kentucky ◽

Professional Career ◽

Current State ◽

Ncaa Athletics ◽

Current Events ◽

The Many ◽

The University

The epilogue turns its attention to Host’s perception of current events and issues about which he is passionate. He addresses problems that are keeping Kentucky from making greater progress, as well as his role in Shaping Our Appalachian Region (SOAR), Kentucky Wired, and the Lexington Urban League. Host expresses his desire for the commonwealth to provide greater support to the University of Kentucky, with a view to making it an elite research university. He also shares his opinions on the current state of NCAA athletics and its governance structure and voices his support for student athletes’ right to control their own likenesses and promote commercial products. Host argues that this would encourage student athletes to stay in school rather than leaving college to become professional athletes. Host concludes the epilogue by thanking the many individuals who have played an important role in his life and professional career.

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