Achieving Electrochemical-Sustainable-Based Solutions for Monitoring and Treating Hydroxychloroquine in Real Water Matrix

Hydroxychloroquine (HCQ) has been extensively consumed due to the Coronavirus (COVID-19) pandemic. Therefore, it is increasingly found in different water matrices. For this reason, the concentration of HCQ in water should be monitored and the treatment of contaminated water matrices with HCQ is a key issue to overcome immediately. Thus, in this study, the development of technologies and smart water solutions to reach the Sustainable Development Goal 6 (SDG6) is the main objective. To do that, the integration of electrochemical technologies for their environmental application on HCQ detection, quantification and degradation was performed. Firstly, an electrochemical cork-graphite sensor was prepared to identify/quantify HCQ in river water matrices by differential pulse voltammetric (DPV) method. Subsequently, an HCQ-polluted river water sample was electrochemically treated with BDD electrode by applying 15, 30 and 45 mA cm−2. The HCQ decay and organic matter removal was monitored by DPV with composite sensor and chemical oxygen demand (COD) measurements, respectively. Results clearly confirmed that, on the one hand, the cork-graphite sensor exhibited good current response to quantify of HCQ in the river water matrix, with limit of detection and quantification of 1.46 mg L−1 (≈3.36 µM) and 4.42 mg L−1 (≈10.19 µM), respectively. On the other hand, the electrochemical oxidation (EO) efficiently removed HCQ from real river water sample using BDD electrodes. Complete HCQ removal was achieved at all applied current densities; whereas in terms of COD, significant removals (68%, 71% and 84% at 15, 30 and 45 mA cm−2, respectively) were achieved. Based on the achieved results, the offline integration of electrochemical SDG6 technologies in order to monitor and remove HCQ is an efficient and effective strategy.

Technical Advances in Aviation Electrification: Enhancing Strategic R&D Investment Analysis through Simulation Decomposition

Computational decision-making in “real world” environmental and sustainability contexts frequently requires the need to contrast numerous uncertain factors and difficult-to-capture dimensions. Monte Carlo simulation modelling has frequently been employed to integrate the uncertain inputs and to construct probability distributions of the resulting outputs. Visual analytics and data visualization can be used to support the processing, analyzing, and communicating of the influence of multi-variable uncertainties on the decision-making process. In this paper, the novel Simulation Decomposition (SimDec) analytical technique is used to quantitatively examine carbon emission impacts resulting from a transformation of the aviation industry toward a state of greater airline electrification. SimDec is used to decompose a Monte Carlo model of the flying range of all-electric aircraft based upon improvements to batteries and motor efficiencies. Since SimDec can be run concurrently with any Monte Carlo model with only negligible additional overhead, it can easily be extended into the analysis of any environmental application that employs simulation. This generalizability in conjunction with its straightforward visualizations of complex stochastic uncertainties makes the practical contributions of SimDec very powerful in environmental decision-making.

Spatial Mixture Copula Model For Multiple Correlated Responses With An Environmental Application

In environmental monitoring, multiple measurements are often collected at many locations and these measurements depend on each other in complex ways, such as nonlinear dependence. In this research, a novel copula-based geostatistical modelling approach was developed to model multivariate continuous spatial random fields using mixture copulas that captures both spatial and joint dependence of multiple responses over two-dimensional locations. In a bivariate context, the mixture copulas were used to capture the joint spatial dependence of a bivariate random field and the spatial copula of the bivariate random field was constructed as the convex combination of mixture copulas. The proposed model was applied to real forest data and simulated nonlinear data. The performance of the novel method was compared with existing spatial methods, which included a univariate spatial pair-copula model, a multivariate spatial pair-copula model that utilises nonlinear principal component analysis (NLPCA), and conventional kriging. The results show that the proposed model outperforms the existing methods in the interpolation of individual responses and reproduction of their bivariate dependence.

Adsorption, and controlled release of doxorubicin from cellulose acetate/polyurethane/multi-walled carbon nanotubes composite nanofibers

The cellulose acetate (CA)/poly (ε-caprolactone diol)/poly (tetramethylene ether) glycol-polyurethane (PCL-Diol/PTMG-PU)/multi-walled carbon nanotubes (MWCNTs) composite nanofibers were prepared via two-nozzle electrospinning on both counter sides of the collector. The performance of synthesized composite nanofibers was investigated as an environmental application and anticancer delivery system for the adsorption/release of doxorubicin (DOX). The synergic effect of MWCNTs and DOX incorporated into the nanofibers was investigated against LNCaP prostate cancer cells. The status of MWCNTs and DOX in composite nanofibers was demonstrated by SEM, FTIR and UV-Vis determinations. The adsorption tests using nanofibrous adsorbent toward DOX sorption was evaluated under various DOX initial concentrations (100-2000 mgL-1 ), adsorption times (5-120 minutes), and pH values (pH:2-9). Due to the fitting of isotherm and kinetic data with Redlich-Peterson and pseudo-second order models, both chemisorption and surface adsorption of DOX molecules mechanisms have been predicted. The drug release from both nanofibers and MWCNTs-loaded nanofibers was compared. The better drug sustained release profiles verified in the presence of composite nanofibers. LNCaP prostate cancer and L929 normal cells were treated to investigate the cytotoxicity and compatibility of synthesized composite nanofibers. The apoptosis/necrosis of hybrid nanofibers and MWCNTs loaded-nanofibers was investigated. The obtained results demonstrated the synergic effects of MWCNTs and DOX loaded-nanofibers on the LNCaP prostate cancer cells death.