Genetic determinants in hyperplasic illnesses of the reproductive system

It were studied some aspects, detecting the role of genetic factors in the genesis of hyperplasic illnesses of reproductive system organs (uterus myoma, inside endometriosis, ovaries endometriosis) on the base of complex investigation of 145 patients with such diseases. Obtained data allow consider the absence in allele PL-All of women the gene GPIII is a risk factor in origin and development of hyperplasic illnesses in reproductive system.

The role of the psychoemotional stress during gestation in the development of obstetrical and perinatal patology

The complex investigation of the perinatal pathology at acute and c/1,1-onic psyclioemotliional stress dunng gestation has been perf 01 wed. Jt was sliown (by tlie metliod of the retrospective analyses) the inaease in the relat-ive 1-isf of tlie premature delivery (1,4-8,0), severe and mild gestosis (3,0-10,0), placental pathology (2,2-3,3 ), anomalies of delivery (2,0-7,0 ), obstetlical Blending (2,0- 2,8 ), late delivery (2,0-7,0) dunng the acute stress. The relationship between tlie pelinatal patology and gestation term was shown dunng the acute stress. Dm'ing- i-lie clironic stress tlie frequency and seventy of pennatal patliology is dependent upon the type of psyclioemotional reaction on the st-ress. The seventy of patliofog-y is more prominent at decompensated type of psychological reaction t-lian at subcompensated type. Tlie newbom infants of motlias witli psyclioemotional stress recuired long rehabilitation in 39,2-50,0% cases.

The viral myocarditis with cardiac аrrhythmia as complication of COVID-19 in the practice of family doctor of the tuberculosis dispensary

BACKGROUND: About 70% of TB dispensary patients have chronic somatic diseases which not only prevent effective treatment of TB but also take progressive course themselves. AIMS: To timely detect and treat acute and chronic somatic disease combined with TB. MATERIALS AND METHODS: since 2020 the algorithm of patient complex investigation by specialists of therapeutic profile was developed in the Tuberculosis Dispensary No. 5, among them the general practitioner was the coordinator of the patients medical route. This became especially relevant during the COVID-19 pandemic. RESULTS: In accordance with the developed algorithms of diagnostic search the patient was comprehensively examined. There were no signs of tuberculosis were in him, however the general practitioner involving to specialists team could diagnose signs of complex cardiac arrhythmia the probable cause which was a new coronavirus infection that he had had six weeks before. CONCLUSIONS: The organization of a new form of medical service for phthisiatric patients allowed general practitioner to reveal serious cardiac pathology directly at the TB dispensary, to refer the patient for consultation to the cardiologist-arrhythmologist, to follow the patient and perform recommended cardiologic treatment simultaneously with measures or medical supervision over persons contacting with tuberculosis.

Fabrication and complex investigation of LAFE based on CNT by PECVD with island catalyst

This paper presents a study of large area field emitter based on carbon nanotubes grown by PECVD method on Si/SiO2 substrate with Fe catalyst. The catalyst was deposited by CVD on the substrate from ferrocene in the form of islands. The sample creation technology was described and results of the emission properties study were presented. Current-voltage characteristics were registered and tested for compliance with the cold field emission regime. The fluctuation statistic of effective microscopic parameters was constructed. Using data from a computerized field projector, the emission profile of the sample was calculated.

Agroecological assessment of leached chernozems with different erosion level in conditions of the slope catena at the Central Chernozemic Region

Based on the complex investigation of agroecological parameters of leached chernozems with different erosion level in conditions of the slope catena at the Central Chernozemic Region (CChR), the features of agrogenic-erosive transformation of morphogenetic, chemical and physic-chemical properties of the investigated soils at the basic levels of their structural organization are shown – depending on the degree of their erosion. The influence of the processes of surface planar erosion and intra-soil lateral migration on the content and distribution of the most problematic heavy metals (HM) – Pb, Cd is considered. The analysis of the research results has shown that the development of erosion processes in conditions of the slope type of terrain characteristic for the CChR leads to a significant transformation of the main diagnostic indicators of the agroecological state of leached chernozems, primarily to the degradation of their morphogenetic and humus profile. The significant and slope-differentiated influence of erosion processes at the level of soil elementary particles, meso- and macro-levels of the soil structural organization has been established. The processes of erosion and lateral migration change the content and profile distribution of Cd and, especially, Pb in the studied leached chernozems. In the eroded soils, there is an increase in their mobility and accumulation in the subsoil. Keywords: LEACHED CHERNOZEMS, AGROECOLOGICAL STATE, EROSION, TRANSFORMATION AND DEGRADATION, HEAVY METALS, LEAD, CADMIUM

The Content of Polyarenes in Soils of Antarctica: Variability across Landscapes

Soil cover of the Earth is faced with intensive polychemical contamination. The pathways of the key pollutants are not investigated enough. Thus, the occasional transportation of soils to remote regions could serve as an informative tool for the elaboration of threshold levels of hazardous materials concentration. One of the most striking examples of such transboundary impact was the transfer of soils and grounds to the Antarctic stations Russkaya and Leningradskaya (before the implementation of the Madrid Protocol in 1991). Thus, the complex investigation of qualitative and quantitative composition of polycyclic aromatic hydrocarbons (PAHs) in soils of various genesis (transported from Eurasia and pristine) of Antarctic have been conducted by the method of high-performance liquid chromatography (HPLC) in a gradient elution mode. The variability of PAHs content was evaluated across landscapes: pristine (the Hudson Mountains and the Haswell Archipelago), contaminated soils (stations Myrniy, Druzhnaya 4 and Bellinshausen) and unique samples of former agrosoils transported by fly in-fly of polar staff from St. Petersburg to Antarctic for local polar greenhouses in the Soviet times, when it was not strictly prohibited. The selected objects of study allow us to not only estimate the degree of contamination of Antarctic soils and grounds, but to also make it possible to assess the rate of PAH degradation in Antarctic conditions. Both high molecular and low molecular PAHs are accumulated following intense anthropogenic activity (fossil organic fuel combustion). The PAHs pool is dominated by low molecular weight representatives (naphthalene, phenanthrene, fluoranthene, pyrene). In most cases, the highest concentrations of benz(a)pyrene does not exceed the Russian Threshold Standard rate, which is the strictest one in the world. The statistical analysis of raw data allowed us to conclude that the contamination of pristine soils of Antarctica across variable landscapes is at the very initial stage. However, we recorded extremely high levels of PAHs in the transported former agrosoils. We can assume that our data could be used as background levels for the elaboration of threshold concentrations of the PAHs for such an internationally managed region as Antarctica.

Transcriptomic landscape of blood platelets in healthy donors

Blood platelet RNA-sequencing is increasingly used among the scientific community. Aberrant platelet transcriptome is common in cancer or cardiovascular disease, but reference data on platelet RNA content in healthy individuals are scarce and merit complex investigation. We sought to explore the dynamics of platelet transcriptome. Datasets from 204 healthy donors were used for the analysis of splice variants, particularly with regard to age, sex, blood storage time, unit of collection or library size. Genes B2M, PPBP, TMSB4X, ACTB, FTL, CLU, PF4, F13A1, GNAS, SPARC, PTMA, TAGLN2, OAZ1 and OST4 demonstrated the highest expression in the analysed cohort, remaining substantial transcription consistency. CSF3R gene was found upregulated in males (fold change 2.10, FDR q < 0.05). Cohort dichotomisation according to the median age, showed upregulated KSR1 in the older donors (fold change 2.11, FDR q < 0.05). Unsupervised hierarchical clustering revealed two clusters which were irrespective of age, sex, storage time, collecting unit or library size. However, when donors are analysed globally (as vectors), sex, storage time, library size, the unit of blood collection as well as age impose a certain degree of between- and/or within-group variability. Healthy donor platelet transcriptome retains general consistency, with very few splice variants deviating from the landscape. Although multidimensional analysis reveals statistically significant variability between and within the analysed groups, biologically, these changes are minor and irrelevant while considering disease classification. Our work provides a reference for studies working both on healthy platelets and pathological conditions affecting platelet transcriptome.

Disposal of a Homicide Victim by Dismemberment and Burning

Burning can have a profound effect on the appearance of bone and increase its susceptibility to mechanical damage. In criminal cases where there has been a deliberate attempt to dispose of human remains in this way; there is also often a need to distinguish between damage caused by heat, ante-mortem and peri-mortem trauma, and post-mortem damage. This case demonstrates how the forensic anthropologist and archaeologist contributed to a complex investigation where a homicide victim had been dismembered, burned and concealed. The use of archaeological and anthropological techniques at the scene, in the mortuary and the laboratory, provided evidence that enabled the sequence of events surrounding the disposal of the deceased to be reconstructed. The expert witness testimony given in court showed the benefits of employing these skills and assisted in securing the conviction of the offenders who are both serving life sentences.