scholarly journals Mucinous Cystadenocarcinoma of Pancreas - USG and CT Evaluation - A Case Report

2021 ◽  
Vol 10 (32) ◽  
pp. 2680-2683
Author(s):  
Avi Vinod Jain ◽  
Suresh V. Phatak ◽  
Laxmi Bishnoi ◽  
Rohan Kumar Singh ◽  
Prerna Patwa
Keyword(s):  
Pancreatic Neoplasms ◽  
Mucinous Cystadenoma ◽  
Cystic Teratoma ◽  
The Body ◽  
Cystic Degeneration ◽  
Cystic Neoplasm ◽  
Pancreatic Cysts ◽  
Low Grade ◽  
Important Place ◽  
Cystic Pancreatic Neoplasms

Cystic neoplasms of the pancreas comprise a pathologically heterogeneous group of tumours with many shared clinical features. Although relatively uncommon, they have a very important place within the surgical pathology of the pancreas because of their high cure rate and their potential (and not infrequent) confusion with the far more common pancreatic pseudocysts. Their exact incidence is unknown, but it is frequently quoted that they constitute about 10 % of all cystic lesions of the pancreas.1 The cystic pancreatic lesions are pathologically classified as - cystic teratoma, common cystic pancreatic neoplasms (serous cystadenoma, mucinous cystic neoplasm, intraductal papillary mucinous neoplasm (IPMN), pseudocyst, rare cystic pancreatic neoplasms (solid pseudopapillary tumour, acinar cell cystadenocarcinoma, lymphangioma, haemangioma, paraganglioma), sarcoma, true epithelial cysts (associated with Von Hippel–Lindau disease, autosomal - dominant polycystic kidney disease, and cystic fibrosis), metastasis, solid pancreatic lesions with cystic degeneration (pancreatic adenocarcinoma, cystic islet cell tumour (insulinoma, glucagonoma, gastrinoma).2 Mucinous cystadenoma of pancreas are more commonly seen in middle‑aged females as compared with males.[5,6] Cystadenomas of the pancreas are low‑grade tumours and they constitute about 10 % of pancreatic cysts.3 Their most common location is the body and tail, with the head being a less common site.4 These tumours are more commonly seen in the middle of the pancreas.

scholarly journals DIAGNOSIS AND MANAGEMENT OF PANCREATIC MUCINOUS CYSTADENOMA

2015 ◽  
Vol 2 (2) ◽  
pp. 63-67
Author(s):  
Lidia Ladea ◽  
Andreea Nicoleta Costache ◽  
F. C. Blăjuț ◽  
V. Tomulescu
Keyword(s):  
Acute Pancreatitis ◽  
Therapeutic Option ◽  
Malignant Lesion ◽  
Mucinous Cystadenoma ◽  
Rare Condition ◽  
The Body ◽  
Pancreatic Cysts ◽  
Benign Tumors ◽  
Recurrent Acute Pancreatitis ◽  
Mucinous Cystadenomas

Pancreatic mucinous cystadenomas (MCAs) are considered to be benign tumors with a high risk of malignant progression. The pancreatic mucinous cystadenoma is considered to be a rare condition that may lead to pancreatic cancer when not surgically resected. MCAs represent 9.7% of all neoplastic pancreatic cysts. The male:female ratio of MCAs is 1:10. The condition appears mostly in women, mean age in the 5th decade. The cyst is restricted by a fibrous capsule of variable consistency and has usually no communication with the pancreatic ductal system. The MCAs are located mostly in the body or tail of the pancreas. The MCAs located in the head of the pancreas are more likely to be malignant. Complete surgical resection is the recommended therapeutic option. We present a case of a 59-year-old female patient admitted in the Departemt of Surgery and Liver Transplatation of Fundeni Clinical Institute for recurrent episodes of acute pancreatitis. After a thorough investigation was performed, the CT-examination showed a pancreatic mass, located in the tail, measuring 30/40mm. Because the CT aspect was specific for a cystic-like lesion, surgery was recommended. The patient underwent a laparoscopic caudal splenopancreatectomy with a favorable postoperative evolution. The particularity of the case comes from the patient’s clinical presentation, with recurrent acute pancreatitis and the imagistic aspect (ultrasound and CT) that initially suggested a pseudocystic-like lesion, but the elevated CA 15-3 and further elaborated examinations indicated a possible malignant lesion.

scholarly journals Mucinous cystic neoplasm of pancreas a case report

2021 ◽  
Vol 8 (12) ◽  
pp. 3714
Author(s):  
Neetha V. ◽  
Anuroop Joe ◽  
Hanumanthaiah K. S. ◽  
Venkatesh S.
Keyword(s):  
Pancreatic Pseudocyst ◽  
Mucinous Cystic Neoplasm ◽  
The Body ◽  
Cystic Neoplasm ◽  
Low Grade ◽  
Mri Contrast ◽  
Contrast Enhanced ◽  
Magnetic Resonance Imaging Mri ◽  
Enhanced Computed Tomography ◽  
Contrast Enhanced Computed Tomography

Mucinous cystic neoplasm of pancreas are relatively rare >95% occur in the body and tail of pancreas. Majority occur in young and middle aged female containing ovarian type subepithelial stroma. These tumors are either premalignant (MCN with low grade dysplasia) or (MCN with high grade dysplasia) or invasive carcinoma. Differential diagnosis includes pancreatic pseudocyst and pancreatic hydatid cyst. Investigations include ultrasonography (USG), Magnetic resonance imaging (MRI), Contrast enhanced computed tomography (CECT) supplemented by endoscopic USG with cyst fluid aspiration.

Immunotherapy and potential predictive biomarkers in the treatment of neuroendocrine neoplasia

2020 ◽  
Author(s):  
Guanghui Xu ◽  
Yuhao Wang ◽  
Hushan Zhang ◽  
Xueke She ◽  
Jianjun Yang
Keyword(s):  
Current Knowledge ◽  
Checkpoint Inhibitors ◽  
Treatment Options ◽  
Predictive Biomarkers ◽  
The Body ◽  
Low Grade ◽  
Ablative Therapies ◽  
Cancer Types ◽  
New Treatment ◽  
Well Differentiated

Neuroendocrine neoplasias (NENs) are a heterogeneous group of rare tumors scattered throughout the body. Surgery, locoregional or ablative therapies as well as maintenance treatments are applied in well-differentiated, low-grade NENs, whereas cytotoxic chemotherapy is usually applied in high-grade neuroendocrine carcinomas. However, treatment options for patients with advanced or metastatic NENs are limited. Immunotherapy has provided new treatment approaches for many cancer types, including neuroendocrine tumors, but predictive biomarkers of immune checkpoint inhibitors (ICIs) in the treatment of NENs have not been fully reported. By reviewing the literature and international congress abstracts, we summarize the current knowledge of ICIs, potential predicative biomarkers in the treatment of NENs, implications and efficacy of ICIs as well as biomarkers for NENs of gastroenteropancreatic system, lung NENs and Merkel cell carcinoma in clinical practice.

Cystic pancreatic neoplasms: a differential diagnosis on CT and MR imaging

2019 ◽  
Vol 6 (4) ◽  
Author(s):  
Silvia Pellegrino ◽  
Dario Giambelluca ◽  
Roberto Cannella ◽  
Cecilia Gozzo ◽  
Giovanni Caruana ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Mr Imaging ◽  
Pancreatic Neoplasms ◽  
Cystic Pancreatic Neoplasms

Pancreatic Cysts: Pathologic Classification, Differential Diagnosis, and Clinical Implications

2009 ◽  
Vol 133 (3) ◽  
pp. 423-438 ◽  
Author(s):  
Olca Basturk ◽  
Ipek Coban ◽  
N. Volkan Adsay
Keyword(s):  
Differential Diagnosis ◽  
Malignant Potential ◽  
Common Finding ◽  
Pancreatic Cysts ◽  
Pancreatic Ducts ◽  
Low Grade ◽  
Cystic Lesions ◽  
Dismal Prognosis ◽  
Cystic Tumors ◽  
Pathologic Classification

Abstract Context.—Cystic lesions of the pancreas are being recognized with increasing frequency and have become a more common finding in clinical practice because of the widespread use of advanced imaging modalities and the sharp drop in the mortality rate of pancreatic surgery. Consequently, in the past 2 decades, the nature of many cystic tumors in this organ has been better characterized, and significant developments have taken place in the classification and in our understanding of pancreatic cystic lesions. Objective.—To provide an overview of the current concepts in classification, differential diagnosis, and clinical/biologic behavior of pancreatic cystic tumors. Data Sources.—The authors' personal experience, based on institutional and consultation materials, combined with an analysis of the literature. Conclusions.—In contrast to solid tumors, most of which are invasive ductal adenocarcinomas with dismal prognosis, cystic lesions of the pancreas are often either benign or low-grade indolent neoplasia. However, those that are mucinous, namely, intraductal papillary mucinous neoplasms and mucinous cystic neoplasms, constitute an important category because they have well-established malignant potential, representing an adenoma-carcinoma sequence. Those that are nonmucinous such as serous tumors, congenital cysts, lymphoepithelial cysts, and squamoid cyst of pancreatic ducts have no malignant potential. Only rare nonmucinous cystic tumors that occur as a result of degenerative/necrotic changes in otherwise solid neoplasia, such as cystic ductal adenocarcinomas, cystic pancreatic endocrine neoplasia, and solid-pseudopapillary neoplasm, are also malignant and have variable degrees of aggressiveness.

Some aspects of hemostasis in the tactics of the ophthalmologist. Literature review

2021 ◽  
pp. 265-270
Author(s):  
O.M. Stanishevskaya ◽  
◽  
M.A. Safronova ◽  
G.V. Bratko ◽  
I.Y. Efremova ◽  
...  
Keyword(s):  
Open Angle Glaucoma ◽  
Vascular Diseases ◽  
Laboratory Diagnosis ◽  
The Body ◽  
Vascular Pathology ◽  
Treatment Result ◽  
Important Place ◽  
Correct Orientation ◽  
Pathological Conditions ◽  
Wide Range

Disorders of hemostasis occupy an important place in the structure of vascular diseases and are one of the most frequent pathological conditions encountered in practical medicine. The hemostasis system is naturally the most vulnerable system of the body. Violations of its balance are found in a wide variety of physiological and pathological conditions of the body. It is not uncommon for the first debut of decompensation to lead to an ophthalmologist. In the practice of an ophthalmologist, there are diseases when it is necessary to pay close attention to thrombophilic conditions. Changes in the hemostatic system, affect a wide range of vascular diseases of the eyeball. Recognition of the type of thrombophilia and its timely laboratory diagnosis in patients with vascular diseases of the retina and optic nerve are important in achieving the best treatment results. Multidisciplinary approach to the treatment of vascular diseases of the eyeball and modern diagnostics, including the study of hemostasis, is necessary and relevant to achieve the best clinical and functional treatment result. Timely and correct orientation of patients in vascular pathology is extremely important due to the fact that concomitant systemic pathology can aggravate the course of the disease, therefore, the choice of treatment tactics for this category of patients should be carried out in conjunction with a therapist, cardiologist, hematologist and endocrinologist. Key words: hemostasis, thrombosis CVS, diabet, primary open-angle glaucoma thrombodynamica, cardiovascular pathology.

Classification of diseases of the gastrointestinal tract in the practice of a family doctor

2021 ◽  
pp. 8-13
Author(s):  
Aleksey Borisovich Petrukhin
Keyword(s):  
Gastrointestinal Tract ◽  
Digestive System ◽  
Family Doctor ◽  
The Body ◽  
Internal Organs ◽  
Important Place ◽  
High Prevalence ◽  
Classification Of Diseases ◽  
Diagnosis Of Diseases

Gastroenterology belongs to one of the leading branches of therapy. In the structure of diseases of the internal organs, diseases of the digestive system occupy a particularly important place due to their high prevalence, which increases with age. As a rule, these diseases have a chronic, progressive, recurrent course, which ultimately leads to severe disorders of the activity of many organs and systems of the body. The article presents the basic requirements for the formation of a clinical diagnosis of diseases of the gastrointestinal tract, which are most common in the practice of a family doctor.

Progression of Cystic Pancreatic Neoplasms – a Uni-Center Cohort Study Over 6 Years

2021 ◽  
Author(s):  
M Kaess ◽  
D Amissah ◽  
W Schorr ◽  
J Schedel ◽  
O Pech
Keyword(s):  
Cohort Study ◽  
Pancreatic Neoplasms ◽  
Cystic Pancreatic Neoplasms

Intralobular Distribution of Ovarian-like Stroma in Pancreatic Mucinous Cystic Neoplasms: Hypothesis on Its Tumorigenesis

2021 ◽  
Author(s):  
Yuki Fukumura ◽  
Yuko Kinowaki ◽  
Yoko Matsuda ◽  
Masaru Takase ◽  
Momoko Tonosaki ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Wnt Pathway ◽  
Smooth Muscle Actin ◽  
Mucinous Cystic Neoplasm ◽  
Cystic Neoplasm ◽  
Pancreatic Ducts ◽  
Low Grade ◽  
Muscle Actin ◽  
Cystic Neoplasms ◽  
Mucinous Cystic Neoplasms

Abstract Pancreatic mucinous cystic neoplasm (MCN) harbors two histological components, tumor epithelia and ovarian-like stroma (OLS). To examine the tumorigenesis of pancreatic MCNs, this study analyzed the distribution, amount, immunohistochemical phenotype, presence of theca cells of the OLS, and the alteration of tumor epithelium of 29 surgically resected MCN cases and compared them with tumor sizes. Non-mucinous type epithelium was present in all low-grade MCNs but its ratio decreased with tumor size (p < 0.05), suggesting that epithelial mucinous changes are a progression phenomenon. The intralobular distribution of OLS was observed in 27.6 % of MCN cases and its existence related to a smaller size (p< 0.05), suggesting intralobular generation of MCNs. Nuclear expression of β-catenin was observed for OLS of everywhere, suggesting consistent activation of the Wnt pathway for OLS. Three MCN cases (10.3%) contained a-smooth muscle actin (SMA)-negative OLS, where OLS surrounding dilated pancreatic ducts or MCN cysts were a-SMA-positive and otherwise negative, suggesting that a-SMA-positivity is an acquired phenomenon of OLS. With this study, we could hypothesize that pancreatic MCNs may generate intralobularly. Epithelial mucinous change and a-SMA-positivity of OLS may be progression phenomena. This is the first study to show the intralobular distribution of OLS.

Cartesian Scientia and the Human Soul

Vivarium ◽  
2008 ◽  
Vol 46 (3) ◽  
pp. 418-442 ◽  
Author(s):  
Lilli Alanen
Keyword(s):  
Physical Nature ◽  
The Body ◽  
Natural Phenomenon ◽  
Human Soul ◽  
Important Place ◽  
New Science

AbstractDescartes's conception of matter changed the account of physical nature in terms of extension and related quantitative terms. Plants and animals were turned into species of machines, whose natural functions can be explained mechanistically. This article reflects on the consequences of this transformation for the psychology of human soul. In so far the soul is rational it lacks extension, yet it is also united with the body and affected by it, and so it is able to act on extended matter. The article examines Descartes's concept of scientia and his different uses of nature, and argues that there is much more continuity between Aristotelian and Cartesian psychology than is usually recognized when it comes to an explanation of the functions of the embodied human soul. If this makes psychology unfit for inclusion in the new science of nature, its object is still a natural phenomenon and has an important place within scientia as Descartes conceived of it.

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