The Fecal Microbiome and Metabolome of Pitt Hopkins Syndrome, a Severe Autism Spectrum Disorder

GI disturbances in ASD such as severe constipation can be medically significant and often require medication. This is especially true for individuals with PTHS, suggesting that the gut microbiome may be involved in PTHS’s pathology.

Pathological post-obstructive diuresis following obstructive uropathy due to constipation in the post-partum period: a case report

Background Constipation during pregnancy is not uncommon. Usually, this does not warrant extensive evaluation and settles with minor interventions or lifestyle modifications. Severe fecal impaction in chronically constipated patients can rarely lead to obstructive uropathy. Relief of obstruction can result in a diuretic phase which may be self-limiting or pathological. However, occurrence of pathological post-obstructive diuresis as a result of severe constipation is an extremely rare complication during pregnancy and puerperium which can even be fatal if not promptly diagnosed and adequately monitored and timely intervened. We describe the management of a pathological post-obstructive diuresis which occurred in the immediate postpartum period after treatment of severe constipation and obstructive uropathy. Case presentation A woman who had undergone an emergency caesarean section due to deep transverse arrest 1 week ago, presented with fecal impaction and anuria. On relief of urinary obstruction which had developed secondary to fecal impaction, she developed pathological post-obstructive diuresis. Careful and timely monitoring with exact fluid replacement, correction of electrolyte imbalances and multidisciplinary care ensured complete recovery of the patient. Conclusions Despite obstructive uropathy being uncommon in obstetric practice, clinicians need to have a high index of suspicion to monitor and promptly manage the potentially life-threatening condition of post-obstructive diuresis in pregnant and puerperal women undergoing urinary tract decompression. Due to unreliability of laboratory cutoff values in pregnancy and puerperium, a more vigilant and multidisciplinary approach with lower threshold for intervention is more prudent in the management of these patients.

Acute Respiratory Distress Syndrome and Feculent Airway Casts due to Severe Constipation

Acute respiratory distress syndrome (ARDS) is a disabling and potentially lethal syndrome requiring prompt recognition and urgent interventions to prevent morbidity and mortality[1]. Although constipation is not generally recognized as a cause for ARDS or usually listed within the differential diagnosis, there have been case reports describing such an association[2,3]. We present the case of a patient with history of intermittent constipation presenting with progressive abdominal pain and an acute abdomen that required emergent surgical fecal decompaction. This was followed by hypoxemic respiratory distress leading to respiratory failure in the setting of severe constipation and aspirated feculent material. To our knowledge, this is the first published case report describing aspirated feculent material in a child with respiratory failure due to ARDS.

Dolichocolon Presenting with Bilateral Hydronephrosis in a Neonate

Background. Dolichocolon is an inborn anatomic variant of the colon with redundancies often causing constipation and/or volvulus presenting in childhood, adolescence, or adulthood. To the best of our knowledge, this is the first case of dolichocolon presenting in infancy with constipation and bilateral hydronephrosis. Case Presentation. A nineteen-day-old neonate presented to the emergency department with severe constipation and discomfort. During his admission, he developed pyelonephritis, and subsequent ultrasound of the kidneys and bladder showed bilateral hydroureteronephrosis. A barium enema was performed and it showed a dolichocolon. Enemas and lactulose were initiated with good effect on both the constipation as well as the hydronephrosis. Conclusions. Dolichocolon in a neonate can cause severe constipation which could also lead to an obstructive nephropathy if untreated. Monitoring of urine flow might be indicated when a neonate presents with severe constipation.

Rectal stump mucocele after a Hartmann’s procedure causing mechanical ileus

Two years after a Hartmann’s procedure, an 85-year-old woman was admitted at our emergency department with abdominal bloating and severe constipation for 5 days. Abdominal CT showed a large rectal stump mucocele associated with compression of surrounding structures, causing a mechanical ileus and a bilateral pyelocaliceal dilatation. Successful transanal drainage with a rectal catheter allowed rapid recovery.

REVIEW OF CHARACTERISTIC FEATURES OF ABHRAKA WSR TO PINAKA ABHRAKA

Rasashastra (Vedic chemistry) is the root branch of the Ayurveda (the science of life) that deals with herbomineral preparations. Abhraka (mica) is a mineral that classified in Maharasa group of Rasashastra. It contains several elements such as Si, Fe, Al, Mg, Na, and K as main ingredients. Four types of abhrakas are described in the Classics of Rasashastra including pinaka. Property of Pinaka is told that when it is heated on fire, the layers get separates. Intake of its bhasma causes severe constipation. The characteristic effect of pinak abhraka can be correlated with muscovite – paragonite micas. Because their perfect basal cleavage allows them to be split into thin, flexible sheets. Muscovite–paragonite series group of mica having hydrous potassium, sodium, aluminum, and silicate minerals. In this hydrous group, aluminum hydroxide causes constipation. In this paper, an attempt will be made to explain how does pinaka abhrak causes severe constipation.

Constipação Crônica: Tratamento com Ventosaterapia - Estudo de Caso

Background: Constipation is a symptom defined by the ocurrence of any manifestation such as ificulty or pain when evacuationg and bowel movements less than three times a week. In recent years, chronic intestinal constipation has been considered a public heath problem due to its high prevalence. There are several types of constipation among the functional one stands out which is characterized by the absence of defined organic causes, usually treated with the ingestion of fibers, liquids and physical exercises. Conventional methods with diets and medicines are not always sufficient. Objective: Analyzing the effects of treatment with ventosatherapy in severe constipation. Methods: A questionnaire was prepared and applied to the person responsible for the municipal health department of each municipality. Results: Clinical case study with a 28-year-old volunteer patient with severe constipation. The technique used in the study was sliding cupping therapy. One session a week was held for 13 weeks. Conclusion: The symptoms of constipation disappeared in the fourth session contiuing with a daily bowel movement until the end of the intervention. The sliding method therapy technique was effective in the treatment of severe constipation.