Background:
Targeting of drugs to the subcellular compartments represents one of the modern
trends in molecular pharmacology. The approach for targeting mitochondria was developed nearly
50 years ago, but only in the last decade has it started to become widely used for delivering drugs. A
number of pathologies are associated with mitochondrial dysfunction, including cardiovascular, neurological,
inflammatory and metabolic conditions.
Objective:
This mini-review aims to highlight the role of mitochondria in pathophysiological conditions
and diseases, to classify and summarize our knowledge about targeting mitochondria and to review the
most important preclinical and clinical data relating to the antioxidant lipophilic cations MitoQ and
SkQ1.
Methods:
This is a review of available information in the PubMed and Clinical Trials databases (US
National Library of Medicine) with no limiting period.
Results and Conclusion:
Mitochondria play an important role in the pathogenesis of many diseases and
possibly in aging. Both MitoQ and SkQ1 have shown many beneficial features in animal models and in
a few completed clinical trials. More clinical trials and research efforts are needed to understand the
signaling pathways influenced by these compounds. The antioxidant lipophilic cations have great potential
for the treatment of a wide range of pathologies.
Synthesis and Ex Vivo Biological Evaluation of Gallium-68 Labelled NODAGA Chelates Assessing Cardiac Uptake and Retention
