A Golgi Apparatus-Targeting, Naphthalimide-Based Fluorescent Molecular Probe for the Selective Sensing of Formaldehyde

Formaldehyde (FA) is a colorless, flammable, foul-smelling chemical used in building materials and in the production of numerous household chemical goods. Herein, a fluorescent chemosensor for FA is designed and prepared using a selective organ-targeting probe containing naphthalimide as a fluorophore and hydrazine as a FA-binding site. The amine group of the hydrazine reacts with FA to form a double bond and this condensation reaction is accompanied by a shift in the absorption band of the probe from 438 nm to 443 nm upon the addition of FA. Further, the addition of FA is shown to enhance the emission band at 532 nm relative to the very weak fluorescent emission of the probe itself. Moreover, a high specificity is demonstrated towards FA over other competing analytes such as the calcium ion (Ca2+), magnesium ion (Mg2+), acetaldehyde, benzaldehyde, salicylaldehyde, glucose, glutathione, sodium sulfide (Na2S), sodium hydrosulfide (NaHS), hydrogen peroxide (H2O2), and the tert-butylhydroperoxide radical. A typical two-photon dye incorporated into the probe provides intense fluorescence upon excitation at 800 nm, thus demonstrating potential application as a two-photon fluorescent probe for FA sensing. Furthermore, the probe is shown to exhibit a fast response time for the sensing of FA at room temperature and to facilitate intense fluorescence imaging of breast cancer cells upon exposure to FA, thus demonstrating its potential application for the monitoring of FA in living cells. Moreover, the presence of the phenylsulfonamide group allows the probe to visualize dynamic changes in the targeted Golgi apparatus. Hence, the as-designed probe is expected to open up new possibilities for unique interactions with organ-specific biological molecules with potential application in early cancer cell diagnosis.

Conformation of G-quadruplex Controlled by Click Reaction

G-quadruplexes are non-canonical four stranded secondary structures possessing great biological importance. Controlling G-quadruplex conformation for further regulating biological processes is both exciting and challenging. In this study, we described a method for regulating G-quadruplex conformation by click chemistry for the first time. 8-ethynyl-2′-deoxyguanosine was synthesized and incorporated into a 12-nt telomere DNA sequence. Such a sequence, at first, formed mixed parallel/anti-parallel G-quadruplexes, while it changed to anti-parallel after reaction with azidobenzene. Meanwhile, the click reaction can give the sequence intense fluorescence.

The photophysical properties and imaging application of a new polarity-sensitive fluorescent probe

We develop a new polarity-sensitive fluorescent probe that displays weak fluorescence in low-polarity solvents and intense fluorescence in high-polarity solvents.

Confined supramolecular polymers in water with exceptional stability, photoluminescence and chiroptical properties

Lipid-encased chiral supramolecular polymer nanorods (SPNRs), synthesized by the nanoprecipitation method in water from a hydrophobic naphthalene-diimide derivative, exhibit excellent thermal stability, intense fluorescence and strong CPL.

Germanane synthesis with simultaneous covalent functionalization: towards highly functionalized fluorescent germananes

We describe exfoliation and subsequent modification of calcium germanide, which yields layered germanium materials with alkyl or aryl groups. Different organic functional group covalently derivatized layered germananes exhibit very intense fluorescence.

Core/shell upconversion nanoparticles with intense fluorescence for detecting doxorubicin in vivo

Doxorubicin (Dox) is a chemotherapy medication used to treat cancer.

Correction: Core/shell upconversion nanoparticles with intense fluorescence for detecting doxorubicin in vivo

Correction for ‘Core/shell upconversion nanoparticles with intense fluorescence for detecting doxorubicin in vivo’ by Junshan Hu et al., RSC Adv., 2018, 8, 21505–21512.