spontaneous recombination
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Doklady BGUIR ◽  
2022 ◽  
Vol 19 (8) ◽  
pp. 50-57
Author(s):  
N. N. Vorsin ◽  
A. A. Gladyshchu ◽  
T. L. Kushner ◽  
N. P. Tarasiuk ◽  
S. V. Chugunov ◽  
...  

Ternary AlGaN alloys with a band gap of 3.4 to 6.2 eV are very promising for photodetectors in the UV wavelength range. Using the COMSOL MULTIPHYSICS software based on AlGaN, a p-i-n photodiode model was developed, including its I–V characteristic, spectral sensitivity of the received radiation, absorption coefficient as a function of the aluminum fraction and the depletion layer thickness. To calculate the process of interaction of a semiconductor with EM radiation, we used a model based on the use of an element of the transition matrix through the carrier lifetime during spontaneous recombination. In this case, the peak sensitivity of the photodiode is from 0.08 to 0.18 A/W at wavelengths of 0.2–0.33 µm. This is in line with experimental results taken from the relevant literature.



Author(s):  
М.Е. Муретова ◽  
Ф.И. Зубов ◽  
Л.В. Асрян ◽  
Ю.М. Шерняков ◽  
М.В. Максимов ◽  
...  

Using numerical simulation, a search is carried out for designs of asymmetric barrier layers (ABLs) for a laser diode having GaAs waveguide and emitting at the wavelength λ = 980 nm. A pair of ABLs, adjoining the active region on both sides, blocks undesired charge carrier flows and suppresses parasitic spontaneous recombination in the waveguide layers. Optimal designs of ABLs based on AlGaAsSb and GaInP for blocking electrons and holes, respectively, are proposed that make it possible to reduce the parasitic recombination current down to less than 1% of the initial value. To suppress electron transport, an alternative structure based on three identical AlInAs barriers is also proposed. The GaAsP spacers separating these barriers from each other have different thicknesses. Due to this, its own set of quasi-bound (resonant) states is formed in each spacer that is different from the neighbor spacer set of states. As a result of this, the resonant tunneling channels are blocked: the parasitic electron flow is reduced by several tens of times in comparison with the case of spacers of equal thickness.



2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Alicia R. Lane ◽  
Indeara C. Cogdell ◽  
Thomas M. Jessell ◽  
Jay B. Bikoff ◽  
Francisco J. Alvarez

AbstractRenshaw cells (RCs) are one of the most studied spinal interneurons; however, their roles in motor control remain enigmatic in part due to the lack of experimental models to interfere with RC function, specifically in adults. To overcome this limitation, we leveraged the distinct temporal regulation of Calbindin (Calb1) expression in RCs to create genetic models for timed RC manipulation. We used a Calb1 allele expressing a destabilized Cre (dgCre) theoretically active only upon trimethoprim (TMP) administration. TMP timing and dose influenced RC targeting efficiency, which was highest within the first three postnatal weeks, but specificity was low with many other spinal neurons also targeted. In addition, dgCre showed TMP-independent activity resulting in spontaneous recombination events that accumulated with age. Combining Calb1-dgCre with Parvalbumin (Pvalb) or Engrailed1 (En1) Flpo alleles in dual conditional systems increased cellular and timing specificity. Under optimal conditions, Calb1-dgCre/Pvalb-Flpo mice targeted 90% of RCs and few dorsal horn neurons; Calb1-dgCre/En1-Flpo mice showed higher specificity, but only a maximum of 70% of RCs targeted. Both models targeted neurons throughout the brain. Restricted spinal expression was obtained by injecting intraspinally AAVs carrying dual conditional genes. These results describe the first models to genetically target RCs bypassing development.



Author(s):  
В.В. Козловский ◽  
А.Э. Васильев ◽  
П.А. Карасев ◽  
А.А. Лебедев

AbstractMathematical simulation of the cascade of displacements in SiC is used to consider the specific features of Frenkel-pair generation upon the scattering of 8- and 15-MeV protons. The distribution histograms of energies acquired not only by primary knocked-out atoms, but also by recoil atoms generated in displacement cascades, are calculated. An analysis of the histograms considers two energy ranges. In the first range of “low” energies, the spontaneous recombination of genetically related Frenkel pairs is dominant. Recoil atoms in the second range have a higher energy, which enables these atoms to leave the spontaneousrecombination zone and dissociate into isolated components. The compensation of lightly doped n - and p -4 H -SiC samples grown by gas-phase epitaxy is experimentally studied under irradiation with 8- and 15-MeV protons. The carrier removal rates are measured. The calculated and experimental data are compared and estimates are obtained for the size of the spontaneous-recombination zone.



Genome ◽  
2016 ◽  
Vol 59 (7) ◽  
pp. 493-500 ◽  
Author(s):  
Beatriz Goñi ◽  
Muneo Matsuda ◽  
Yoshiko N. Tobari

With few exceptions, spontaneous crossing over does not normally occur in male Drosophila. Drosophila ananassae males show considerable amounts of crossing over. In wild males of D. ananassae from Asian (2008) and Brazilian populations (1986 and 2007) variable frequencies of meiotic crossing over, estimated from chiasmata counts, suggested the existence of factors controlling male crossing over in these populations. To corroborate for such prediction, we present data on spontaneous recombination in F1 males of D. ananassae heterozygous for chromosomes of the same Brazilian populations (1986) and marker chromosomes using three testers stocks. Mean recombination value was low, although high variability existed between individual frequencies. Recombination frequencies between lines in each tester stock were not significantly different, excepting when the 3ple-px and 3ple-cy testers were compared (p < 0.05). These two testers differ in respect to the regional distribution of crossovers. The occurrence of recombination in chromosomes 2 and 3 in F1 males tested with e65 se; bri ru was not related, suggesting they are under independent genetic control. Our data are consistent with proposed genetic factors controlling male crossing over in the tester stocks and to the presence of enhancers and suppressors of male crossing over segregating in the Brazilian populations (1986).







2007 ◽  
Vol 27 (22) ◽  
pp. 7816-7827 ◽  
Author(s):  
Jason A. Smith ◽  
Laura A. Bannister ◽  
Vikram Bhattacharjee ◽  
Yibin Wang ◽  
Barbara Criscuolo Waldman ◽  
...  

ABSTRACT We designed DNA substrates to study intrachromosomal recombination in mammalian chromosomes. Each substrate contains a thymidine kinase (tk) gene fused to a neomycin resistance (neo) gene. The fusion gene is disrupted by an oligonucleotide containing the 18-bp recognition site for endonuclease I-SceI. Substrates also contain a “donor” tk sequence that displays 1% or 19% sequence divergence relative to the tk portion of the fusion gene. Each donor serves as a potential recombination partner for the fusion gene. After stably transfecting substrates into mammalian cell lines, we investigated spontaneous recombination and double-strand break (DSB)-induced recombination following I-SceI expression. No recombination events between sequences with 19% divergence were recovered. Strikingly, even though no selection for accurate repair was imposed, accurate conservative homologous recombination was the predominant DSB repair event recovered from rodent and human cell lines transfected with the substrate containing sequences displaying 1% divergence. Our work is the first unequivocal demonstration that homologous recombination can serve as a major DSB repair pathway in mammalian chromosomes. We also found that Msh2 can modulate homologous recombination in that Msh2 deficiency promoted discontinuity and increased length of gene conversion tracts and brought about a severalfold increase in the overall frequency of DSB-induced recombination.



Gene ◽  
2006 ◽  
Vol 372 ◽  
pp. 199-207 ◽  
Author(s):  
Atsushi Iguchi ◽  
Sunao Iyoda ◽  
Jun Terajima ◽  
Haruo Watanabe ◽  
Ro Osawa


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