Indirect cytotoxicity evaluations of antibacterial raw silk fabric doped with calcium, copper and zinc on fibroblasts and osteoblasts

Antibacterial materials are widely used to prevent hospital-acquired infections. In our previous report, metal (calcium, copper or zinc)-doped raw silk fabrics were shown to possess strong antibacterial activities against Escherichia coli. However, antibacterial materials may occasionally be harmful to the human body; thus, in this study, we investigated the cytotoxicities of extracts from metal-doped raw silk fabrics with respect to fibroblasts and osteoblasts indirectly. Calcium-doped raw silk fabric demonstrated cytocompatibility with fibroblasts. Contrarily, copper- and zinc-doped raw silk fabrics remarkably decreased the cell densities of fibroblasts, indicating their cytotoxic effects. This observation could be attributed to the high concentrations of the released copper or zinc ions. However, calcium-, copper- and zinc-doped raw silk fabrics did not demonstrate any cytotoxic effects on osteoblasts because a high concentration of the serum alleviated the effects of these metal ions released from the fabrics. Thus, calcium-doped raw silk fabric is a promising antibacterial material that does not induce strong cytotoxicity. This study will facilitate the design of materials that are both antibacterial and safe.

Calcium-Doped Boron Nitride Aerogel Enables Infrared Stealth at High Temperature Up to 1300 °C

Boron nitride (BN) aerogels, composed of nanoscale BN building units together with plenty of air in between these nanoscale building units, are ultralight ceramic materials with excellent thermal/electrical insulation, great chemical stability and high-temperature oxidation resistance, which offer considerable advantages for various applications under extreme conditions. However, previous BN aerogels cannot resist high temperature above 900 °C in air atmosphere, and high-temperature oxidation resistance enhancement for BN aerogels is still a great challenge. Herein, a calcium-doped BN (Ca-BN) aerogel with enhanced high-temperature stability (up to ~ 1300 °C in air) was synthesized by introducing Ca atoms into crystal structure of BN building blocks via high-temperature reaction between calcium phosphate and melamine diborate architecture. Such Ca-BN aerogels could resist the burning of butane flame (~ 1300 °C) and keep their megashape and microstructure very well. Furthermore, Ca-BN aerogel serves as thermal insulation layer, together with Al foil serving as both low-infrared-emission layer and high-infrared-reflection layer, forming a combination structure that can effectively hide high-temperature target (heated by butane flame). Such successful chemical doping of metal element into crystal structure of BN may be helpful in the future design and fabrication of advanced BN aerogel materials, and further extending their possible applications to extremely high-temperature environments.

Preparation and Properties of Calcium Doped Carbon Nanofibers Photothermal Reagent

Recently, carbon nanomaterials illustrated great application prospect in tumor photothermal therapy (PTT). Meanwhile, numerous studies have shown that destruction of calcium homeostasis in cells can also be used as an effective strategy to inhibit tumor. Therefore, dual effect Ca2+ doped carbon nanofibers (PCNFs-Ca) photothermal reagents were prepared by electrospinning technique in this study. The spinnability, morphology and photothermal effect of different content of calcium doped carbon nanofibers were analyzed by field emission scanning electron microscopy (SEM), X-ray diffraction (XRD) and infrared thermometer. The results suggested that a dual effect photothermal reagent with high Ca2+ content was prepared to achieve significant effect in tumor inhibition on the premise of less influence on the photothermal properties of carbon nanofibers.