The article shows that for the development of science, technology, and education, it is necessary to create an adequate information and analytical system to support the adoption of effective management decisions. One of the main difficulties of this task is that it should be solved comprehensively, and not in fragments, as it is done at present. After all, in the structure of the Russian Government there is no body for centralized management of the solution of this issue. Therefore, many state programs in this area are not coordinated with each other and are not supported by the necessary personnel, standards, and legal and information provision. All this will have to be created anew in the context of increasing attempts to isolate Russia economically and politically by the United States and its supporters in the countries of the European Union (EU). The author suggests using this geopolitical situation to review the strategy and tactics of Russia's scientific and technological development, making it a priority to increase the efficiency of using its own intellectual potential and expand scientific and technological cooperation with other countries. First of all, it should be the BRICS countries, the Eurasian Economic Union, as well as China, India, Iran and South Korea, which also face acute problems of scientific and technological development.