pharmaceutical materials
Recently Published Documents


TOTAL DOCUMENTS

172
(FIVE YEARS 28)

H-INDEX

29
(FIVE YEARS 2)

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2194
Author(s):  
Kostas Giannis ◽  
Carsten Schilde ◽  
Jan Henrik Finke ◽  
Arno Kwade

The purpose of this work is to simulate the powder compaction of pharmaceutical materials at the microscopic scale in order to better understand the interplay of mechanical forces between particles, and to predict their compression profiles by controlling the microstructure. For this task, the new framework of multi-contact discrete element method (MC-DEM) was applied. In contrast to the conventional discrete element method (DEM), MC-DEM interactions between multiple contacts on the same particle are now explicitly taken into account. A new adhesive elastic-plastic multi-contact model invoking neighboring contact interaction was introduced and implemented. The uniaxial compaction of two microcrystalline cellulose grades (Avicel® PH 200 (FMC BioPolymer, Philadelphia, PA, USA) and Pharmacel® 102 (DFE Pharma, Nörten-Hardenberg, Germany) subjected to high confining conditions was studied. The objectives of these simulations were: (1) to investigate the micromechanical behavior; (2) to predict the macroscopic behavior; and (3) to develop a methodology for the calibration of the model parameters needed for the MC-DEM simulations. A two-stage calibration strategy was followed: first, the model parameters were directly measured at the micro-scale (particle level) and second, a meso-scale calibration was established between MC-DEM parameters and compression profiles of the pharmaceutical powders. The new MC-DEM framework could capture the main compressibility characteristics of pharmaceutical materials and could successfully provide predictions on compression profiles at high relative densities.


2021 ◽  
Vol 2063 (1) ◽  
pp. 012024
Author(s):  
Huda T Thuiny ◽  
Tarek A Fahad ◽  
Asaad A Ali

Abstract Procaine hydrochloride was used as an aromatic amine, and salicylic acid (5-[2-(diethylamino)-4-benzoateazo]-2-hydroxybenzoic acid) was used to make a new azodye derived from pharmaceutical materials ( PS ).C.H.N., H1-NMR, I.R., and visible spectroscopic techniques have also been used to characterize dye. At different pH values ( 2 - 12 ), the electronic spectra of this azo dye was investigated in terms of acid-base properties, which included defining isobestic points and determining protonation and ionization constants. The effect of different polarities of solvents on the electronic spectra was the subject of another study. The dye has been used in a variety of applications, including as an indicator for strong acid with strong base and for nitrite determination.


2021 ◽  
Author(s):  
Atsushi Nakanishi ◽  
Koichiro Akiyama ◽  
Shohei Hayashi ◽  
Hiroshi Satozono ◽  
Kazuue Fujita

We demonstrated the ability to perform spectroscopic imaging of pharmaceutical material using a compact ultra-broadband THz DFG source.


Crystals ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1088
Author(s):  
Cristóbal Verdugo-Escamilla ◽  
Carolina Alarcón-Payer ◽  
Antonio Frontera ◽  
Francisco Javier Acebedo-Martínez ◽  
Alicia Domínguez-Martín ◽  
...  

The design of new multicomponent pharmaceutical materials that involve different active pharmaceutical ingredients (APIs), e.g., drug-drug cocrystals, is a novel and interesting approach to address new therapeutic challenges. In this work, the hydrochlorothiazide-caffeine (HCT–CAF) codrug and its methanol solvate have been synthesized by mechanochemical methods and thoroughly characterized in the solid state by powder and single crystal X-ray diffraction, respectively, as well as differential scanning calorimetry, thermogravimetric analyses and infrared spectroscopy. In addition, solubility and stability studies have also been performed looking for improved physicochemical properties of the codrug. Interestingly, the two reported structures show great similarity, which allows conversion between them. The desolvated HCT–CAF cocrystal shows great stability at 24 h and an enhancement of solubility with respect to the reference HCT API. Furthermore, the contribution of intermolecular forces on the improved physicochemical properties was evaluated by computational methods showing strong and diverse H-bond and π–π stacking interactions.


Sign in / Sign up

Export Citation Format

Share Document