Clinical psychologists with specialist knowledge and skills in palliative care can be described as palliative psychologists. Whether as core members of a palliative care team or as consultants, palliative psychologists can become involved soon after a diagnosis of serious illness and continue to provide care during treatment, transitions of care, during the dying process, and in bereavement. The distress patients and family caregivers may experience is on a continuum and may involve both psychological and spiritual factors. When the patient and family coping strategies become depleted or are inadequate to face the challenges imposed by illness, suffering can ensue. The palliative psychologist may offer assessment and management of anxiety, depression, and other types of psychological distress. Grief reactions should always receive special and ongoing attention to determine whether the distress is manageable or whether psychological or psychiatric intervention is warranted. Because of the ongoing interplay of psychological and spiritual concerns, palliative psychologists can effectively use spiritual screening and the spiritual history to understand spiritual and existential needs, and help integrate spiritual care into the psychotherapy session. This offers the opportunity to collaborate with spiritual care providers in the psychospiritual care of the patient and the family. Maintaining professional self-care is also a mandate for palliative psychologists and includes the timely recognition of risk factors for professional distress, protective factors, and meaningful interventions.