Crystal structure of 2-{[5-amino-1-(phenylsulfonyl)-1H-pyrazol-3-yl]oxy}-1-(4-methylphenyl)ethan-1-one

In the title compound, C18H17N3O4S, the pyrazole ring is planar, with the sulfur atom lying 0.558 (1) Å out of the ring plane. The NH2 group is involved in an intramolecular hydrogen bond to a sulfonyl oxygen atom; its other hydrogen atom forms an asymmetric three-centre hydrogen bond to the two oxygen atoms of the —O—CH2—C=O— grouping, via the 21 screw axis, forming a ribbon structure parallel to the b axis. Translationally adjacent, coplanar ribbons form a layer parallel to (10\overline{4}).

Determining Genus From Sandpile Torsor Algorithms

We provide a pair of ribbon graphs that have the same rotor routing and Bernardi sandpile torsors, but different topological genus. This resolves a question posed by M. Chan [Cha]. We also show that if we are given a graph, but not its ribbon structure, along with the rotor routing sandpile torsors, we are able to determine the ribbon graph's genus. Comment: Reformatted for DMTCS

Design and analysis of the Wing-spread Bridge: a pedestrian bridge in the Binjiang Avenue, Shanghai

<p>Along Binjiang Avenue, the landscape in Shanghai, China, a footbridge is needed to connect the two sides of the Qiantanyoucheng park. In this paper, the "Wing-spread Bridge" is designed and analyzed based on the environment and human requirements. The initial inspiration for this bridge comes from the stress ribbon structure. In the Wing-spread Bridge's structural design, the stress ribbon and arch are combined to reduce both components' horizontal force. Meanwhile, abutment, arch foot, and bridge tower are combined as one tower, and this tower is shaped like a dove according to the surrounding natural conditions. The combination and adjustment of the components make the structure beautiful and competitive in the landscape. Finally, this bridge's FE model is established, and the static is carried out based on it. The results show that the bridge can meet the specification requirements in static aspects.</p>

Rational cross-sectional design and behavioural analysis of the low-sag stressed ribbon pedestrian bridges/Rationale Querschnittsbemessung und Verhaltensanalyse der Fußgänger-Spannbandbrücken mit geringem Durchhang

Stress ribbon bridges represent one of the simplest and the most efficient modern bridge constructions used in modern lightweight pedestrian bridges. The article presents an analysis of the stress ribbon bridge behaviour by applying different values of constant loads, assessing the possibilities of using steels and composite materials. The article presents the methodology for the rational cross-section and shape design of the low-sag stressed ribbon structure, based on the rigidity conditions. The article discusses the structure‘s behaviour in asymmetric loads and provides recommendations for Design.

Fifteen 4-(2-methoxyphenyl)piperazin-1-ium salts containing organic anions: supramolecular assembly in zero, one, two and three dimensions

Fifteen 4-(2-methoxyphenyl)piperazin-1-ium salts containing organic anions have been prepared and structurally characterized. In the isostructural 4-chlorobenzoate and 4-bromobenzoate salts, C11H17N2O+·C7H4ClO2 − (I) and C11H17N2O+·C7H4BrO2 − (II), and the 4-iodobenzoate salt C11H17N2O+·C7H4IO2 − (III), the ions are linked by N—H...O hydrogen bonds, forming centrosymmetric R 4 4(12) four-ion aggregates; a similar aggregate is formed in the 2-chlorobenzoate salt (V), isomeric with (I). In the 2-fluorobenzoate salt C11H17N2O+·C7H4FO2 − (IV), and the isomorphous pair of salts, the 2-bromobenzoate (VI), isomeric with (II) and 2-iodobenzoate (VII), isomeric with (III), N—H...O and C—H...π(arene) interactions link the components into three-dimensional arrays. Four-ion R 4 4(12) aggregates are also found in the 2-methylbenzoate, 4-aminobenzoate and 4-nitrobenzoate salts, C11H17N2O+·C8H7O2 − (VIII), C11H17N2O+·C7H6NO2 − (IX) and C11H17N2O+·C7H4NO4 − (X), but those in (IX) are linked into complex sheets by an additional N—H...O hydrogen bond. In the 3,5-dinitrobenzoate salt, C11H17N2O+·C7H3N2O6 −·2H2O (XI), N—H...O and O—H...O hydrogen bonds link the components into a complex ribbon structure. In the picrate salt, C11H17N2O+·C6H2N3O7 − (XII), the four-ion aggregates are linked into chains of rings by C—H...O hydrogen bonds. In the hydrogen maleate salt, C11H17N2O+·C4H3O4 − (XIII), two- and three-centre hydrogen bonds link the ions into a ribbon structure while both anions contain very short but asymmetric O—H...O hydrogen bonds, having O...O distances of 2.4447 (16) and 2.4707 (17) Å. O—H...O Hydrogen bonds link the anions in the hydrogen fumarate salt (XIV), isomeric with (XIII), into chains that are linked into sheets via N—H...O hydrogen bonds. In the hydrogen (2R,3R)-tartrate salt, C11H17N2O+·C4H5O6 −·1.698H2O (XV), the anions are linked into sheets by O—H...O hydrogen bonds. Comparisons are made with the structures of some related compounds.

MTCL2 is a new Golgi-resident microtubule-regulating protein, essential for organizing asymmetric microtubule network

The Golgi apparatus plays important roles in organizing the asymmetric microtubule network essential for polarized vesicle transport. The Golgi-associated coiled-coil protein MTCL1 is crucially involved in Golgi functioning by interconnecting and stabilizing microtubules on the Golgi membrane through its N- and C-terminal microtubule-binding domains. Here, we report the presence of a mammalian paralog of MTCL1, named MTCL2, lacking the N-terminal microtubule-binding domain. MTCL2 localizes to the Golgi membrane through the N-terminal region and directly binds microtubules through the conserved C-terminal domain without promoting microtubule stabilization. Knockdown experiments demonstrated essential roles of MTCL2 in accumulating MTs around the Golgi and regulating the Golgi ribbon structure. In vitro wound healing assays further suggested a possible intriguing activity of MTCL2 in integrating the centrosomal and Golgi-associated microtubules around the Golgi ribbon, thus supporting directional migration. Altogether, the present results demonstrate that cells utilize two members of the MTCL protein family to differentially regulate the Golgi-associated microtubules for controlling cell polarity.

Roles of GOLPH3, a PI(4)P binding protein, in the physiopathology of cancer

Golgi phosphoprotein 3 (GOLPH3), a Phosphatidylinositol 4-Phosphate [PI(4)P] effector at the Golgi, is required for several intracellular functions, including Golgi ribbon structure maintenance, Golgi glycosylation and vesicle trafficking. It is amplified in several solid tumor types and its overexpression correlates with poor prognosis. GOLPH3 influences tumorigenesis through (i)&nbsp;regulation of Golgi-to-plasma membrane trafficking; (ii) turnover and glycosylation of cancer-relevant glycoproteins; (iii) influence on DNA damage response and maintenance of genomic stability.