Recent Progresses of Deep Learning in Drug Discovery

: Deep learning, an emerging field of artificial intelligence based on neural network in machine learning, has been applied in various fields and is highly valued. Herein we mainly review several mainstream architectures in deep learning, including deep neural networks, convolutional neural networks and recurrent neural networks in the field of drug discovery. The applications of several architectures in molecular de novo design, property prediction, biomedical imaging and synthetic planning have also been explored. We also discuss the future direction of the deep learning approaches and the main challenges we need to address.

Stimuli-responsive conductive hydrogels: design, property and applications

Stimuli-responsive conductive hydrogel has been emerged as a new surging concept in hydrogel research field due to its combined advantages of stimuli-responsivity and conductivity from conductive polymers (such as polyaniline,...

Prediksi Understandability Pada CK Metrics Object Oriented Menggunakan Fuzzy Inference System

The ability of the software to easily understand it is very important, to evaluate the performance of a system or process a certain mechanism is needed. So that the achievement level of software development is obtained, the assessment of code quality and design in the metrics have different contributions to the quality properties of software design. The assessment of software characteristics is described in a model based on the Chidamber Kemerer (CK) Entropy Metrics design property indicator. Measure specific properties of the software by mapping them into numbers according to objective and well-defined measurement rules. To be able to help perform the software quality calculation process based on CK metrics on the eclipse equinox data by using the Mamdani fuzzy inference system, pointing the classification into low which can be interpreted as having good quality. And the value affirmation of the deffuzzyfication method in this case is done by using the COA (center of area) method, to determine the crisp x value, obtained from the membership function formed from the composition process of all outputs.

Design Methodology: From the Achievements of Historical Development to the Problems of Modern Functioning

The research presents a general analysis of the design methodology development, which deals with the main global trends, but still appeals more to the design property and problems of the post-Soviet countries. The purpose of the present study is to analyze modern manifestations of the crisis in design methodology. It is based on the topicality of performance of its important role in providing thought and organizing design practice. The implementation of the research goal became possible owing to general logical methods of analysis and synthesis, the historical method, and methods of induction and deduction. The study found that the achievements of the USSR design methodology, which had been developed and tested in the 1960–80s of the twentieth century, have not become in demand in modern science. On the other hand, a more detailed analysis revealed the proximity of their essential content to modern design approaches, which had been proposed after the 1990s by researchers and experts of Western design. In particular, it is a question of comparison of the “Design-program” approach and the principles of so-called “Design-thinking”, which is popular nowadays; the concept of the environmental approach and the thesis of “Environmental design”; experiments on the emotional image formation in design and the concept of “Emotional design”. In addition to stating lost opportunities and time, broken ties of scientific heredity, etc., it is important to realize the reasons of this case. It is also essential to become aware that along with objective circumstances of ideological, organizational or material causes, there are also subjective ones, which are significant too. So, the subconscious feeling that your own values are more important than others will neither contribute to the development of a National Design Model (in the context of globalization of the world cultural space), nor to the formation of the functioning methodology accordingly. Particularly, when this feeling is combined with a super-loyal and uncritical attitude to other people’s opinions.

The design(ing) of language

Courses on invented languages can do much more than just introduce students to linguistics. Through three case studies, it is shown that as students learn how to design a language, they also learn about the design of human language in a way that is unlikely to occur in other courses. The first case study involves the creation of a lexicon, in relation to John Wilkins’ invented language of 1668 and to Saussurean arbitrariness, commonly regarded as a fundamental design property of human language. The second case study concerns phonemic inventories. By designing their own from scratch, students see the competing pressures that phonemic inventories must satisfy in all languages. The third case study concerns inflectional morphology and the pressures that determine the form of particular morphemes. All of these case studies are accessible to students and help them engage with important aspects of the design properties of human language.

DNA Origami Design: A How-To Tutorial

While the design and assembly of DNA origami are straightforward, its relative novelty as a nanofabrication technique means that the tools and methods for designing new structures have not been codified as well as they have for more mature technologies, such as integrated circuits. While design approaches cannot be truly formalized until design-property relationships are fully understood, this document attempts to provide a step-by-step guide to designing DNA origami nanostructures using the tools available at the current state of the art.

Estimating the Value of Excess: A Case Study of Gaming Computers, Consoles and the Video Game Industry

A widely held belief among design practitioners is that an ideal design solution is the one that meets all the requirements while minimizing surplus cost incurred by exceeding requirements. In this research, we challenge this notion by exploring if providing design “excess”, the ability of a solution to exceed certain requirements, can increase the value of a solution to its end users. A case study is performed in the video game industry to explore if design excess is prevalent and its impact on the industry. This study is performed by examining various PC builds (budget, mid-range, and high-end dream) and gaming consoles (Microsoft Xbox and Sony PlayStation) over an 18-year period. Based on a thorough investigation of video game requirements and capacity of different hardware, we find that design excess has existed in computer hardware and is intentionally used as a design property. The results indicate that mid-range solution provide the greatest value to its customers. Further, PC excess based value is adjusted during years when consoles are released. Using measurements of excess, this study also reveals a shift in technology push versus pull that occurs during the mid-2000s and is observable through the lens of system excess.

Sistem Informasi Pemasaran Property CV. Hoki Jaya Property

CV. Hoki Jaya Property merupakan suatu perusahaan yang memberikan jasa design property, borongan rumah dan service. CV. Hoki Jaya Property mempunyai visi membuat bangunan terkonsep dan berkualitas. Bangunan berkualitas dengan harga yang terjangkau membuat orang-orang tertarik untuk menggunakan jasa dari HJP (Hoki Jaya Property). Tidak hanya menjual rumah berkualitas, HJP juga memberikan jasa renovasi rumah dan design rumah. Namun, kendala yang dialami perusahaan adalah kesulitan dalam memasarkan property atau rumah secara detail dan luas. Maka dari itu, penulis melakukan Praktek Kerja Lapangan di CV. Hoki Jaya Property guna membangun dan mengembangkan sebuah website Sistem Informasi Pemasaran Property dengan harapan dapat membantu perusahaan dalam memasarkan properti secara detail dan dapat dijangkau oleh masyarakat luas serta meningkatkan kuantitas penjualan properti.