The Structure of Multiphase Galactic Winds

We present a novel analytic framework to model the steady-state structure of multiphase galactic winds comprised of a hot, volume-filling component and a cold, clumpy component. We first derive general expressions for the structure of the hot phase for arbitrary mass, momentum, and energy source terms. Next, informed by recent simulations, we parameterize the cloud–wind mass transfer rates, which are set by the competition between turbulent mixing and radiative cooling. This enables us to cast the cloud–wind interaction as a source term for the hot phase and thereby simultaneously solve for the evolution of both phases, fully accounting for their bidirectional influence. With this model, we explore the nature of galactic winds over a broad range of conditions. We find that (i) with realistic parameter choices, we naturally produce a hot, low-density wind that transports energy while entraining a significant flux of cold clouds, (ii) mixing dominates the cold cloud acceleration and decelerates the hot wind, (iii) during mixing thermalization of relative kinetic energy provides significant heating, (iv) systems with low hot phase mass loading factors and/or star formation rates can sustain higher initial cold phase mass loading factors, but the clouds are quickly shredded, and (v) systems with large hot phase mass loading factors and/or high star formation rates cannot sustain large initial cold phase mass loading factors, but the clouds tend to grow with distance from the galaxy. Our results highlight the necessity of accounting for the multiphase structure of galactic winds, both physically and observationally, and have important implications for feedback in galactic systems.

Side-by-Side Comparison of Five Chelators for 89Zr-Labeling of Biomolecules: Investigation of Chemical/Radiochemical Properties and Complex Stability

In this work, five different chelating agents, namely DFO, CTH-36, DFO*, 3,4,3-(LI-1,2-HOPO) and DOTA-GA, were compared with regard to the relative kinetic inertness of their corresponding 89Zr complexes to evaluate their potential for in vivo application and stable 89Zr complexation. The chelators were identically functionalized with tetrazines, enabling a fully comparable, efficient, chemoselective and biorthogonal conjugation chemistry for the modification of any complementarily derivatized biomolecules of interest. A small model peptide of clinical relevance (TCO-c(RGDfK)) was derivatized via iEDDA click reaction with the developed chelating agents (TCO = trans-cyclooctene and iEDDA = inverse electron demand Diels-Alder). The bioconjugates were labeled with 89Zr4+, and their radiochemical properties (labeling conditions and efficiency), logD(7.4), as well as the relative kinetic inertness of the formed complexes, were compared. Furthermore, density functional theory (DFT) calculations were conducted to identify potential influences of chelator modification on complex formation and geometry. The results of the DFT studies showed—apart from the DOTA-GA derivative—no significant influence of chelator backbone functionalization or the conjugation of the chelator tetrazines by iEDDA. All tetrazines could be efficiently introduced into c(RGDfK), demonstrating the high suitability of the agents for efficient and chemoselective bioconjugation. The DFO-, CTH-36- and DFO*-modified c(RGDfK) peptides showed a high radiolabeling efficiency under mild reaction conditions and complete 89Zr incorporation within 1 h, yielding the 89Zr-labeled analogs as homogenous products. In contrast, 3,4,3-(LI-1,2-HOPO)-c(RGDfK) required considerably prolonged reaction times of 5 h for complete radiometal incorporation and yielded several different 89Zr-labeled species. The labeling of the DOTA-GA-modified peptide was not successful at all. Compared to [89Zr]Zr-DFO-, [89Zr]Zr-CTH-36- and [89Zr]Zr-DFO*-c(RGDfK), the corresponding [89Zr]Zr-3,4,3-(LI-1,2-HOPO) peptide showed a strongly increased lipophilicity. Finally, the relative stability of the 89Zr complexes against the EDTA challenge was investigated. The [89Zr]Zr-DFO complex showed—as expected—a low kinetic inertness. Unexpectedly, also, the [89Zr]Zr-CTH-36 complex demonstrated a high susceptibility against the challenge, limiting the usefulness of CTH-36 for stable 89Zr complexation. Only the [89Zr]Zr-DFO* and the [89Zr]Zr-3,4,3-(LI-1,2-HOPO) complexes demonstrated a high inertness, qualifying them for further comparative in vivo investigation to determine the most appropriate alternative to DFO for clinical application.

Dynamics of a flexible body: a two-field formulation

A two-field formulation of the nonlinear dynamics of an elastic body is presented in which positions/orientations and the resulting velocity field are treated as independent. Combining a nonclassical description of elastic velocity that includes the convection velocity due to elastic deformation with floating reference axes minimizing the relative kinetic energy due to elastic deformation provides a fully uncoupled expression of kinetic energy. A transformation inspired by the classical Legendre transformation concept is introduced to develop the motion equations in canonical form. Finite element discretization is achieved using the same shape function sets for elastic displacements and velocities. Specific attention is brought to the discretization of the gyroscopic forces induced by elastic deformation. A model reduction strategy to construct superelement models suitable for flexible multibody dynamics applications is proposed, which fulfills the essential condition of orthogonality between a rigid body and elastic motions. The problem of expressing kinematic connections at superelement boundaries is briefly addressed. Two academic examples have been developed to illustrate some of the concepts presented.

The influence of surface charge on the coalescence of ice and dust particles in the mesosphere and lower thermosphere

Agglomeration of charged ice and dust particles in the mesosphere and lower thermosphere is studied using a classical electrostatic approach, which is extended to capture the induced polarisation of surface charge. Collision outcomes are predicted whilst varying the particle size, charge, dielectric constant, relative kinetic energy, collision geometry and the coefficient of restitution. In addition to Coulomb forces acting on particles of opposite charge, instances of attraction between particles of the same sign of charge are discussed. These attractive forces are governed by the polarisation of surface charge and can be strong at very small separation distances. In the mesosphere and lower thermosphere, these interactions could also contribute to the formation of stable aggregates and contamination of ice particles through collisions with meteoric smoke particles.

The influence of surface charge on the coalescence of ice and dust particles in the mesosphere

Agglomeration of charged ice and dust particles in the mesosphere is studied using a classical electrostatic approach, which is extended to capture the induced polarisation of surface charge. Collision outcomes are predicted whilst varying particle size, charge, dielectric constant, relative kinetic energy, collision geometry and the coefficient of restitution. In addition to attractive Coulomb forces acting on particles of opposite charge, instances of strong attraction between particles of the same sign of charge are predicted, which take place at small separation distances and also lead to the formation of stable aggregates. These attractive forces are governed by the polarisation of surface charge.

Nanoparticles Synthesis in Wet-Operating Stirred Media: Investigation on the Grinding Efficiency

The use of nanomaterials, thanks to their peculiar properties and versatility, is becoming central in an increasing number of scientific and engineering applications. At the same time, the growing concern towards environmental issues drives the seeking of alternative strategies for a safer and more sustainable production of nanoparticles. Here we focus on a low-energy, magnetically-driven wet milling technique for the synthesis of metal nanoparticles starting from a bulky solid. The proposed approach is simple, economical, sustainable, and provides numerous advantages, including the minimization of the nanoparticles air dispersion and a greater control over the final product. This process is investigated by experiments and discrete element method simulations to reproduce the movement of the grinding beads and study the collision dynamics. The effect of several parameters is analyzed, including the stirring bar velocity, its inclination, and the grinding bead size, to quantify the actual frequency, energy, and angle of collisions. Experiments reveal a non-monotonous effect of the stirring velocity on the abrasion efficiency, whereas numerical simulations highlight the prevalent tangential nature of collisions, which is only weakly affected by the stirring velocity. On the other hand, the stirring velocity affects the collision frequency and relative kinetic energy, suggesting the existence of an optimal parameters combination. Although a small variation of the stirring bar length does not significantly affect the collision dynamics, the use of grinding beads of different dimensions offers several tuning opportunities.

Inter-Area Oscillations Stabilization by Type-2 Fuzzy Based Novel Resistor Brake Model

Inter-area power oscillation is an inherent problem of weakly interconnected power systems. This paper introduces fuzzy logic controller of Type-2 to organize the interventions of novel resistor bake model for inter-area oscillation stabilization in Kundur's two-area benchmark test power system via MATLAB/Simulink-based modelling and simulation environment with the help of Interval Type-2 fuzzy logic controller toolbox. The propositioned controller uses the relative kinetic energy deviation between the two areas as an input control signal. Three case studies, including small, mild, and severe disturbances should elucidate the effectuality of the propositioned scheme. The obtained comparative time-domain simulation results should prove that the suggested stabilization regime is a reliable mean for treating the issue of inter-area power oscillations.

A New Traffic Conflict Measure for Electric Bicycles at Intersections

As electric bicycles (e-bikes) are becoming popular in China, concerns have been raised about their safety conditions. A traffic conflict technique is commonly used in traffic safety analysis, and there are many conflict measures designed for cars. However, e-bikes have high flexibility to change speed and trajectories, which is different from cars, so the conflict measures defined for e-bikes need to be independently explored. Based on e-bike driving characteristics, this paper proposes a new measure, the Integrated Conflict Intensity (ICI), for traffic conflicts involving e-bikes at intersections. It measures the degree of dangerousness of a conflict process, with consideration of both conflict risk and conflict severity. Time to collision is used to measure the conflict risk. Relative kinetic energy is used to measure the conflict severity. ICI can be calculated based on video analysis. The method of determining ICI thresholds for three conflict levels (serious, less serious, and slight) and two conflict types (conflicts between two e-bikes, and conflicts between an e-bike and a car) is put forward based on the questionnaires about safety perception of e-bike riders, which is regarded as the criterion of e-bike safety conditions at intersections. The video recording and a questionnaire survey about conflicts involving e-bikes at intersections have been conducted, and the unified thresholds applicable to different intersections have been determined. It is verified that ICI and its thresholds meet the criterion of e-bike safety conditions. This work is expected to be used in the selection of intersections for safety improvement of e-bike traffic.