Solvodynamic study on Solubility Enhanced Lovastatin in presence of Arginine as Cosolute

In this study, the solute-cosolute interaction, solute-solvent interaction involved in the solubilisation process of ARG solutions and LVS-ARG solution systems are illustrated. The sound velocity values of both solution systems were determined at varying concentrations of ARG (0.01-0.8 mol.dm-3) at 298.15 K. Next, the refractive index and the density of the solution systems was measured at temperature range from 298.15 to 313.15K. Acoustic and volumetric parameters such as isentropic compressibility (KS), apparent isentropic molar compressibility (KSΦ), relative association (RA), acoustic impedance (Z), internal pressure (πi), free volume (Vf), molar volume (Φv0), molar expansibility (ΦE0) were calculated from sound velocity and density data. From the study, an increasing trend in sound velocity was observed with the increase in ARG concentration while compressibility values showed opposite trend. Additionally, solute-solvent interaction and structural effects of water for ARG and LVS-ARG systems are discussed regarding the changes in acoustic parameters.

Study of nitrazepam drug interaction with alcohol: An ultrasonic and physiochemical investigation

The intermolecular interaction between the constituent components of liquid mixtures can be revealed by ultrasonic analysis. In the present study, interaction of nitrazepam drug with methyl alcohol has been studied and presented using ultrasonic tools. The investigation involves calculation of ultrasonic velocity (ν), density (ρ), viscosity (η) and the associated derived parameters. The specific acoustic impedance (Z), isentropic compressibility(β), relaxation time (τ), intermolecular free length(L_f) and solvation number Sn are calculated to reveal the interaction information. The solvent-solvent and solute-solvent interaction between the nitrazepam and alcohol molecules is considered. To see the impact of nitrazepam drug with alcohol in ordinary day to day scenario, investigation is carried out at normal temperature and pressure conditions with temperature range varying from 303K to 313K range. The results indicate increased molecule association of nitrazepam drug in presence of alcohol. This study suggests the presence of synergistic depressants effect, when nitrazepam drug is used with alcohol.

Molecular Interaction of Aqueous Solution of 1-Propanol and 2-Propanol

Viscosities (ƞ) of solutions of 1- propanol and 2-propanol have been determined in aqueous systems of varying composition (0.16-3.64 mol dm-3) at 298 K. The ƞ/ƞ0 data have been analyzed in the light of reduced Jone-Dole equation ƞ/ƞ0 = BC+1. The results in the regards to solute-solvent interaction in aqueous solutions of both the alcohols have been discussed in the terms of the value B. The result of study reveals that both the alcohols behave as the structure makers in the water. The result shows that solute-solvent type interaction of same magnitude exists in water-alcohol system.