Study of nitrazepam drug interaction with alcohol: An ultrasonic and physiochemical investigation

2021 ◽  
Author(s):  
Chandra Kant Bhardwaj ◽  
Suraj Prakash ◽  
Anjna Kumari
Keyword(s):  
Isentropic Compressibility ◽  
Liquid Mixtures ◽  
Solvation Number ◽  
Solvent Interaction ◽  
Intermolecular Free Length ◽  
Ultrasonic Analysis ◽  
Solute Solvent Interaction ◽  
Temperature And Pressure ◽  
Β Relaxation ◽  
The Impact

The intermolecular interaction between the constituent components of liquid mixtures can be revealed by ultrasonic analysis. In the present study, interaction of nitrazepam drug with methyl alcohol has been studied and presented using ultrasonic tools. The investigation involves calculation of ultrasonic velocity (ν), density (ρ), viscosity (η) and the associated derived parameters. The specific acoustic impedance (Z), isentropic compressibility(β), relaxation time (τ), intermolecular free length(L<sub>f</sub>) and solvation number Sn are calculated to reveal the interaction information. The solvent-solvent and solute-solvent interaction between the nitrazepam and alcohol molecules is considered. To see the impact of nitrazepam drug with alcohol in ordinary day to day scenario, investigation is carried out at normal temperature and pressure conditions with temperature range varying from 303K to 313K range. The results indicate increased molecule association of nitrazepam drug in presence of alcohol. This study suggests the presence of synergistic depressants effect, when nitrazepam drug is used with alcohol.

Solvodynamic study on Solubility Enhanced Lovastatin in presence of Arginine as Cosolute

2021 ◽  
pp. 3631-3638
Author(s):  
NF Zolkiflee ◽  
MMR Meor Mohd Affandi ◽  
ABA Majeed
Keyword(s):  
Sound Velocity ◽  
Isentropic Compressibility ◽  
Structural Effects ◽  
Acoustic Parameters ◽  
Solvent Interaction ◽  
Density Data ◽  
Opposite Trend ◽  
Increasing Trend ◽  
Solute Solvent Interaction ◽  
Molar Expansibility

In this study, the solute-cosolute interaction, solute-solvent interaction involved in the solubilisation process of ARG solutions and LVS-ARG solution systems are illustrated. The sound velocity values of both solution systems were determined at varying concentrations of ARG (0.01-0.8 mol.dm-3) at 298.15 K. Next, the refractive index and the density of the solution systems was measured at temperature range from 298.15 to 313.15K. Acoustic and volumetric parameters such as isentropic compressibility (KS), apparent isentropic molar compressibility (KSΦ), relative association (RA), acoustic impedance (Z), internal pressure (πi), free volume (Vf), molar volume (Φv0), molar expansibility (ΦE0) were calculated from sound velocity and density data. From the study, an increasing trend in sound velocity was observed with the increase in ARG concentration while compressibility values showed opposite trend. Additionally, solute-solvent interaction and structural effects of water for ARG and LVS-ARG systems are discussed regarding the changes in acoustic parameters.

scholarly journals Acoustic assessment in binary mixtures of a polar nuclear extractant, DEHPA with eight non polar diluents at 303.15K – a comparative study

2020 ◽  
Vol 10 (2) ◽  
pp. 5323-5331
Keyword(s):  
Carbon Disulphide ◽  
Isentropic Compressibility ◽  
Liquid Mixtures ◽  
Extraction Process ◽  
Measured Data ◽  
Excess Properties ◽  
Ultrasonic Velocities ◽  
Binary Liquid ◽  
Intermolecular Free Length ◽  
Research Findings

Ultrasonic velocities (U), viscosities (η) and densities (ρ) of binary liquid mixtures of di–(2-ethylhexyl) phosphoric acid (DEHPA) with eight non polar diluents viz. n-pentane, n-hexane, n-heptane, benzene, carbon tetrachloride, cyclohexane, carbon disulphide and dioxane are measured at temperature 303.16 K and 0.01MPa for entire range of concentration. The measured data are used to compute acoustic impedance (Z), isentropic compressibility, intermolecular free length, free volume, internal pressure and viscous relaxation time. The excess properties are also evaluated from the measured data to study inter- and intra-molecular interaction between components of liquid mixtures. The research findings may be utilized in solvent extraction process to enhance extraction efficacy.

scholarly journals Molecular Association Studies on Polyvinyl Alcohol at Different Concentrations

2018 ◽  
Vol 2018 ◽  
pp. 1-5
Author(s):  
Richa Saxena ◽  
S. C. Bhatt
Keyword(s):  
Relaxation Time ◽  
Polyvinyl Alcohol ◽  
Acoustic Impedance ◽  
Association Studies ◽  
Adiabatic Compressibility ◽  
Ultrasonic Velocities ◽  
Acoustical Parameters ◽  
Solvent Interaction ◽  
Intermolecular Free Length ◽  
Solute Solvent Interaction

Ultrasonic velocities, densities, and viscosities have been measured for the solution of polyvinyl alcohol in water at concentration range of 0.3% to 1% at temperature 35°C. Ultrasonic velocities have been measured using variable path ultrasonic interferometer at 1 MHz frequency. The acoustical parameters like adiabatic compressibility, acoustic impedance, intermolecular free length, and relaxation time have been calculated by using above-mentioned values of ultrasonic velocities, densities, and viscosities. The variation of these acoustical parameters is explained in terms of solute-solvent interaction in a polymer solution.

scholarly journals A Comparison Study on Molecular Interaction of an Acidic Organophosphoric Extractant with Substituted Aromatic Hydrocarbon (p-xylene/toluene) at 303.15K

2020 ◽  
Vol 11 (3) ◽  
pp. 10052-10058
Keyword(s):  
Binary Mixtures ◽  
Ultrasonic Velocity ◽  
Aromatic Hydrocarbons ◽  
Molecular Interaction ◽  
Atmospheric Pressure ◽  
Composition Range ◽  
Isentropic Compressibility ◽  
Extraction Process ◽  
Comparison Study ◽  
Intermolecular Free Length

In the present study, the excess molar volume (VE) and the deviations in intermolecular free length (ΔLf), isentropic compressibility (Δβs), acoustic impedance (ΔZ), and ultrasonic velocity (ΔU) were calculated using the experimentally measured values of density (ρ) and ultrasonic velocity (U) of binary mixtures of an acidic organophosphoric extractant (DEHPA) with two substituted aromatic hydrocarbons, i.e., p-xylene and toluene at 303.15K and atmospheric pressure, 0.1MPa over the entire composition range of DEHPA. The results of both binary mixtures have been presented graphically and compared in terms of molecular interaction between unlike molecules of the mixtures, which outcome may be applied in the solvent extraction process.

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